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A hydrogel dressing that effectively promotes wound repair and regeneration, its preparation method and application

A wound repair and hydrogel technology, applied in medical science, bandages, etc., can solve the problems of rare chronic wound ulcers, difficult wound healing, weak healing ability, etc., achieving good healing effect, simple and efficient preparation method, and promoting healing effect

Active Publication Date: 2022-03-08
首都医科大学附属北京潞河医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned composite material repairs the blood-spinal cord barrier after SCI by solution injection, but it is rarely used in the preparation of chronic wound ulcers caused by diabetes, vascular disease, infection, etc. based on the above-mentioned research in the prior art. Wound healing, dressings for acute wound healing or wound healing after severe impact
At present, most of the materials that promote wound healing are dressings, but due to chronic wound ulcers caused by diabetes, vascular diseases, infections, etc., it is difficult to heal acute wounds or wounds after severe collisions, and their own healing ability is relatively weak. Pain and itching during the wound healing phase

Method used

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  • A hydrogel dressing that effectively promotes wound repair and regeneration, its preparation method and application
  • A hydrogel dressing that effectively promotes wound repair and regeneration, its preparation method and application
  • A hydrogel dressing that effectively promotes wound repair and regeneration, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0051] Preparation of blank hydrogel: Preparation of blank hydrogel by an inverted bottle method, taking 330 mg of four arm acrylate polyethylene glycol and 10 mg of DL-dithiosecol, plus 6.8 mL of pH 7.4 PBS In the buffer, stir well, after 20 min, pour a vial, if there is no liquid flow phenomenon, prepare a blank hydrogel, which is recorded as a gelation time. The equation of the reaction of the blank hydrogel and the state of the gelation before and after the preparation of the blank hydrogel figure 1 (A), (b) shown.

preparation example 2

[0053] Heparin - hydrogel dressing preparation:

[0054] Take 330 mg of the four arm acrylate polyethylene glycol and 10 mg of DL-dithiose, adding 6.8 mL of pH of 7.4, PBS buffer, stirred evenly, i.e., obtaining a hydrogel solution;

[0055] In the above hydrogel solution, 1 mg / ml heparin was added, stirred evenly, and after 20 min, there was no liquid flow phenomenon, and the heparin-hydrogel dressing was prepared.

Embodiment 1

[0062] A method of preparing a hydrogel dressing that effectively promotes the restoration of regeneration, including the following steps:

[0063] Preparation of the S1 hydrogel solution: Take 330 mg of four arm acrylate polyethylene glycol and 10 mg of DL-dithiothiol, plus 6.8 mL of pH of 7.4 PBS buffer, stirring at room temperature Uniform, that is, the precoction of hydrogel;

[0064] S2 was added to the hydrogel solution of step S1 and 1 mg / ml of heparin and 500 ng / ml of BFGF, stirred well, after a period of time, no liquid flow phenomenon, i.e., prepared a hydrogel-bFGF dressing.

[0065] Preparation result:

[0066] Michael addition reaction occurs between the four arm acrylate polyethylene glycol and DL-dithiose, which is gelated in PBS buffer pH of 7.4, and its gel is successful after 20 min. The gel time of 20 min provides sufficient operating time for the addition of heparin and BFGF of the present invention; and the heparin has the effect of promoting rubber when p...

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Abstract

The invention discloses a hydrogel dressing that can effectively promote wound repair and regeneration, and its preparation method and application. The preparation method includes the following steps: S1 Prepare raw materials: polymercapto compound and multi-armed polyethylene glycol with double bonds as end groups Alcohol was added to the PBS buffer solution, and after stirring evenly, the hydrogel pre-liquid was obtained; S2, heparin and bFGF were added to the hydrogel solution, stirred, and left to stand until no liquid flowed, and the heparin-bFGF hydrogel dressing was prepared. The prepared heparin-bFGF hydrogel dressing ensures the stable and sustained release of heparin and bFGF for more than 10 days; the heparin-bFGF hydrogel dressing is applied to the wound healing of chronic wound ulcers caused by diabetes, vascular disease, infection, etc. . The heparin-bFGF hydrogel dressing of the present invention has the advantages of effectively slow-releasing exogenous bFGF at the wound and promoting wound healing of chronic wound ulcer.

Description

Technical field [0001] The present invention relates to the technical field of wound repair, and more specifically, it involves an effective promotion of water-gel applications and preparation methods and applications thereof in the wound repair regeneration. Background technique [0002] In daily life, it is necessary for skin tissue damage or damage caused by various external factors and chronic disease or large or small trauma. Otherwise, small trauma will trigger serious ulcers, or even due to External bacterial infection causes the consequences of endangers life. At present, medical dressings can help control hemorrhage, prevent infection and absorption of secretions. With the development of medical development, wound wound healing theory has been widely studied and identified: the main purpose of wet medical dressing is to create a humid environment in the wet surface, enhance macrophages and fibroblasts in humo-sterile environments. Activity, promotes epithelial regenerati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/008A61L26/0066A61L26/0061A61L2300/236A61L2300/406A61L2300/414A61L2300/602C08L71/02
Inventor 赵辉叶霖
Owner 首都医科大学附属北京潞河医院
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