Microfluidic device, sample mixing method and microfluidic system

Abstract

The invention discloses a micro-fluidic device, a sample mixing method and a micro-fluidic system, which are used for quickly mixing samples on the micro-fluidic device and improving the detection efficiency of the micro-fluidic device. The embodiment of the invention provides a micro-fluidic device. A micro-fluidic chip comprises a lower substrate and an upper substrate which are arranged in a box-to-box manner; the lower base plate comprises a lower underlayer base plate and a micro-channel which is positioned on one side, facing the upper base plate, of the lower underlayer base plate and is used for accommodating liquid drops; the upper substrate comprises an upper underlayer substrate, a plurality of electrode groups positioned on one side, facing the lower substrate, of the upper underlayer substrate, and dielectric layers positioned on one sides, facing the lower substrate, of the electrode groups; the orthographic projection of the electrode group falls into the orthographic projection of the micro-channel; and the electrode group is configured to apply a voltage to the electrode group so as to enable the dielectric layer to generate reversible dielectric breakdown.

Description

technical field [0001] The present application relates to the field of microfluidic technology, in particular to a microfluidic device, a sample mixing method, and a microfluidic system. Background technique [0002] Microfluidics is a technology that precisely controls and manipulates micro-scale fluids. Through this technology, researchers can integrate basic operating units such as sample preparation, reaction, separation, and detection into a centimeter-scale chip. Microfluidic technology is generally used in the analysis process of trace drugs in the fields of biology, chemistry, pharmacy, etc. It mainly involves the mixing and transportation of trace reagents. Among them, the mixing of samples is one of the important steps in biochemical detection, which is of great significance to the development of biomedicine, drug diagnosis, food hygiene, environmental monitoring and molecular biology. [0003] In the existing microfluidic technology, sample mixing is generally co...

AI Technical Summary

Problems solved by technology

[0003] In the existing microfluidic technology, sample mixing is generally completed in external equipment such as shakers, centrifuges and other equipment, which is very unfavorable for the integrated development of microfluidic chips

If the sample mixing and incubation process is completed on the microfluidic chip, the concentration gradient or temperature gradient of the sample is generally used to complete the sample mixing through the diffusion effect without using complex external drive equipment. The active mixing method has a long mixing time, which is not conducive to the improvement of the detection efficiency of the microfluidic chip

[0004] In summary, the existing technology cannot quickly mix samples on the microfluidic chip, which affects the detection efficiency of the microfluidic chip

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