Composite material, preparation method thereof, nano-drug and application

A technology of composite materials and raw materials, applied in the field of medicine, can solve the problem that nano-drugs cannot balance the level of ROS, and achieve the effects of avoiding the side effects of pro-inflammatory reactions, high biological safety, and simple preparation method.

Inactive Publication Date: 2020-07-31
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the embodiments of the present invention is to provide a composite material to solve the problem that the existing nanomedicine used for antibacterial photodynamic therapy cannot balance the ROS level during the treatment process proposed in the background art

Method used

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  • Composite material, preparation method thereof, nano-drug and application
  • Composite material, preparation method thereof, nano-drug and application
  • Composite material, preparation method thereof, nano-drug and application

Examples

Experimental program
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Effect test

Embodiment 1

[0069] A kind of composite material, concrete preparation method is as follows:

[0070] 1) Preparation of octahedral ceria: weigh 434.3 mg of Ce(NO 3 ) 3 ·6H 2 O with 3.8 mg of Na 3 PO 4 12H 2 O was dissolved in 10mL and 30mL deionized water respectively to obtain two corresponding solutions, and then the above two solutions were mixed in a polytetrafluoroethylene bottle for 1 hour, and then the polytetrafluoroethylene bottle containing the mixture was placed in a hydrothermal synthesized in a high-pressure reactor, and then transferred the high-pressure reactor to a temperature-controlled constant temperature blast drying oven, heated at 170°C for 12 hours, and then centrifuged at a speed of 9000rpm / min for 15min to obtain a precipitate. Washed twice with water and ethanol, once with deionized water, and dried overnight in a constant temperature oven at 50°C to obtain the octahedral cerium dioxide, denoted as CeO 2 ;

[0071] 2) Surface amination treatment: disperse t...

Embodiment 2

[0076] Compared with Example 1, except that the added amount of the chlorin e6 was replaced by 3.5 mg, the others were the same as in Example 1.

Embodiment 3

[0078] Compared with Example 1, except that the Ce(NO 3 ) 3 ·6H 2 The amount of O added is replaced by 440mg and Na 3 PO 4 12H 2 Except that the add-on of O is replaced as 4mg, other is identical with embodiment 1.

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Abstract

The invention relates to the field of medicines, and particularly discloses a composite material, a preparation method thereof, a nano-drug and an application. The composite material comprises the following raw material substances of octahedral cerium dioxide, NHS, EDC, a photosensitizer and 3-aminopropyl triethoxysilane. The composite material provided by the embodiment of the invention has excellent antibacterial and anti-inflammatory effects, and the composite material prepared from multiple raw materials can maximize the antibacterial and anti-inflammatory treatment effect and reduce the side effect of the photodynamic treatment. The preparation method provided by the invention is simple, the prepared composite material can release ROS in a self-adjusting manner, bacteria are killed byinstantly releasing a large amount of ROS under illumination excitation, and then residual ROS is sequentially and rapidly removed, so that damage to surrounding normal tissues by the ROS is prevented; and the problem that the ROS level cannot be balanced in the treatment process of existing nano-drugs for antibacterial photodynamic therapy is solved, and the biological safety is high.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a composite material, a preparation method thereof, a nano-medicine and an application thereof. Background technique [0002] With the continuous development of science and technology, the pharmaceutical industry has also made rapid progress. Among them, Antibacterial photodynamic therapy (aPDT) is a method to kill bacteria through the instantaneous generation of a large amount of reactive oxygen species (Reactive oxygen species, ROS) in the photocatalytic process, because of its good therapeutic effect and non-toxicity. The characteristics that cause drug resistance have received widespread attention. [0003] At present, more and more nano-medicines for antibacterial photodynamic therapy (such as commercialized photosensitizers based on antibacterial photodynamic therapy, etc.) In the treatment of periodontitis, it has the same effect as local antibiotic treatment of periodontitis, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/02A61K47/18A61K47/24A61K41/00A61P31/04A61P29/00A61P1/02
CPCA61K9/5115A61K9/5123A61K41/0071A61P1/02A61P29/00A61P31/04
Inventor 王林周延民董彪孙悦李春艳
Owner JILIN UNIV
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