Application of isopentenyl substituted phenolic compounds against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus

A phenolic compound and methicillin-resistant technology, applied in the fields of medicine and microbial chemistry, can solve the problems of limited drug development and research work

Active Publication Date: 2021-02-12
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug development research work on it in the prior art is very limited

Method used

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  • Application of isopentenyl substituted phenolic compounds against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus
  • Application of isopentenyl substituted phenolic compounds against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus
  • Application of isopentenyl substituted phenolic compounds against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Anti-Staphylococcus aureus and methicillin-resistant Staphylococcus aureus activity detection of compounds of formula Ⅰ-Ⅳ by McFarland turbidimetry recommended by National Clinical Trial Center

[0033] (1) Configuration of liquid and solid medium

[0034] Preparation method of nutrient broth medium: Weigh 18 g of nutrient broth dry powder (Scientific Research Special Company, the same below) and dissolve it in 1000 mL of distilled water, distribute it in conical flasks, and sterilize at 121 ° C, 0.15 MPa under high temperature and high pressure for 15 min ,spare.

[0035] Preparation method of nutrient agar medium: Weigh 15g of agar dry powder (Guangdong Huankai Microbiology Technology Co., Ltd.) and 18g of nutrient broth dry powder and dissolve them in 1000mL of distilled water. After being sterilized under high temperature and high pressure for 15 minutes, immediately divide the sterilized nutrient agar medium into sterile plates for later use.

[0036] ...

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Abstract

The invention relates to the technical field of medicinal microbial chemistry, and specifically discloses a strain of Bacillus chamois ( Stereum hirsutum ) isolated from the fermentation product of four isopentenyl substituted phenolic compounds for the preparation of antimicrobial drugs, specifically in the preparation of anti-Staphylococcus aureus and methicillin-resistant grape aureus Drug application for cocci growth. The antibacterial activity test of the present invention confirms that isopentenyl substituted phenolic compounds and derivatives thereof of the present invention can significantly inhibit Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (methicillin-resistant Staphylococcus aureus , MRSA), and has the application of preparing new agricultural or medical antibacterial and drug-resistant bacterial drugs.

Description

technical field [0001] The present invention relates to the fields of medicine and microbial chemistry, in particular to a class of prenylated phenolic compounds derived from a strain of Stereum hirsutum used for inhibiting Staphylococcus aureus and methicillin-resistant V. aureus Drug application for cocci growth. Background technique [0002] Microorganisms have existed on the earth for more than 3.8 billion years and exhibit great genetic and metabolic diversity. To survive, they have evolved to adapt to different environments and competing challenges. Humans have also been using antibiotics, antiseptics, and other anti-MRSA agents to prevent and control infection from disease. At present, drug resistance of bacteria, viruses, parasites and other infectious diseases is a huge problem facing people all over the world. Therefore, the development of antibacterial drugs with unique chemical structures and new mechanisms of action is an important task for various scientific...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/365A61K31/216A61P31/04
CPCA61K31/216A61K31/352A61K31/365A61P31/04
Inventor 刘吉开陈贺平赵珍珠
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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