Water-soluble rare earth nanocrystalline, and application and preparation method thereof

Abstract

The invention relates to a water-soluble rare earth nanocrystalline, and application and a preparation method thereof. The preparation method specifically comprises the following steps: mixing an oil-soluble rare earth-based luminescent nanocrystalline stock solution pre-dissolved in trichloromethane with a certain proportion of ethanol and water, then adding an amino diphosphate micromolecular ligand, adjusting the pH value of the water phase to a low pH value (2-3), carrying out stirring, and collecting a supernatant to obtain modified nanocrystalline. The purification mode of the produced nanocrystalline is low-speed centrifugal separation in a neutral aqueous solution, and ultrasonic dispersion is performed in an aqueous solution with a low pH value (4-5); the purified modified productcan be directly coupled with functional molecules activated by succinimide in advance to obtain the nanoprobe with required functions. The nanocrystalline obtained by the functionalization method ishigh in yield, large in amino loading capacity and easy to purify; and the prepared nanoprobe is higher in stability, shows obviously improved efficiency in application based on resonance energy transfer, and has application value in the fields of biomedicine, photovoltaic energy and the like.

Description

technical field [0001] The invention relates to the technical field of application of rare earth nanocrystal materials, in particular to a water-soluble rare earth nanocrystal, its application and a preparation method thereof, which are used for rapid, simple, efficient and stable functionalization of rare earth nanocrystals. Background technique [0002] Rare earth elements refer to 15 elements of the lanthanide series (La to Lu) and scandium (Sc) and yttrium (Y) in the same group IIIB as the lanthanide elements. The rare earth elements commonly referred to as lanthanides mostly refer to lanthanides, because they have unfilled 4f electron orbits and corresponding operating electrons, thus producing abundant electronic energy levels and electronic operating states, and various electronic energy levels produced And the operating state makes this kind of material have rich chemical, optical, magnetic and nuclear energy properties. Therefore, nanocrystals based on rare earths ...

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Problems solved by technology

Due to the long polymer chain, it is unavoidable that the nanocrystals are cross-linked by the polymer during the reaction, and the yield is low

In addition, according to the theory of soft and hard acids and bases, compared with ligands such as carboxyl and amino groups involved in conventional functionalization schemes, the binding ability of rare earth ions and phosphate groups is stronger. Therefore, in experiments related to biological samples, ligand exchange The functionalization scheme is often interfered by a large amount of phosphate in the tissue and the problem of ligand shedding occurs

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