Oral liquid or oral preparation

A technology for oral preparations and oral liquids, applied in the directions of liquid transportation, dispersion transportation, emulsion transportation, etc., can solve the problems of affecting taste, complicated preparation process, slow effect, etc. better results

Inactive Publication Date: 2020-08-11
金科涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"Shengbai Mixture" is good at increasing white blood cells, but it has a poor effect on platelets and red blood cells, and the effect is slow
The preparation is a traditional Chinese medicine compound preparation, and it is an ethanol extract, which causes the ingredients in the formula to be taken as oral preparations to affect the taste. Therefore, the main problem of the current clinical application of this preparation is that the oral acceptance of the preparation is not high due to the extremely poor taste. , the vomiting reaction is obvious after oral administration, and it has a superimposed effect with the gastrointestinal reaction of chemotherapy, which leads to a low acceptance of clinical patients
In addition, the preparation process of the above preparation is complicated, which is not conducive to large-scale industrial production.

Method used

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  • Oral liquid or oral preparation
  • Oral liquid or oral preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: the preparation of oral preparation

[0052] Take 50 g of epimedium crude drug, and use WF80 model universal pulverizer (Jiangyin Xinyou Machinery Manufacturing Co., Ltd.) and jet pulverizer (Sichuan Fengneng Powder Equipment Factory) to carry out wall-breaking pulverization. The crushed epimedium was mixed with 10 g of sucrose and 50 mL of purified water in a vortex mixer, and then packed in a transparent plastic bottle. Microscopic observation showed that the field of vision was all small particles, and the epimedium cells in the mixed solution were all broken. Utilize the Nicomp380N3000 nanometer laser particle size analyzer of American PSS company to measure, the particle size of the small particle in the mixed solution is 300±50nm.

[0053] Through the above process, an oral preparation was prepared, which was a nanoparticle (average particle diameter: 300 nm) suspension comprising Epimedium nanoparticles, a flavoring agent (sucrose) and purified wat...

Embodiment 2

[0057] Embodiment 2: the preparation of oral preparation

[0058] Take 30 g of Epimedium crude drug, and use WF80 model universal pulverizer (Jiangyin Xinyou Machinery Manufacturing Co., Ltd.) and jet pulverizer (Sichuan Fengneng Powder Equipment Factory) to carry out wall-breaking pulverization. The broken epimedium was mixed with 6 g of sucrose and 70 mL of purified water in a vortex mixer, and then packaged in a transparent plastic bottle. Microscopic observation showed that the field of vision was all small particles, and the epimedium cells in the mixed solution were all broken. Utilize the Nicomp380N3000 nanometer laser particle size analyzer of American PSS company to measure, the particle size of the small particle in the mixed solution is 280 ± 40nm.

Embodiment 3

[0059] Embodiment 3: the preparation of oral preparation

[0060] Take 70 g of epimedium crude drug, and use WF80 model universal pulverizer (Jiangyin Xinyou Machinery Manufacturing Co., Ltd.) and jet pulverizer (Sichuan Fengneng Powder Equipment Factory) to carry out wall-breaking pulverization. The broken epimedium was mixed with 14 g of sucrose and 30 mL of purified water in a vortex mixer, and then packaged in a transparent plastic bottle. Microscopic observation showed that the field of vision was all small particles, and the epimedium cells in the mixed solution were all broken. Utilize the Nicomp380N3000 nanometer laser particle size analyzer of American PSS company to measure, the particle diameter of the small particle in the mixed solution is 260±35nm.

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Abstract

The present invention relates to an oral preparation or oral liquid and particularly to the oral preparation or oral liquid that can improve hematopoietic functions of bone marrows (at the same time improve three lines of platelets, white blood cells, and red blood cells), wherein the oral preparation or oral liquid contains or consists of wall-crushed herba epimedii and an optional flavoring agent, wherein particle diameter of the wall-crushed herba epimedii is less than 500 nm, less than 400 nm, less than 300 nm and less than 200 nm, and preferably the flavoring agent is sucrose. The oral liquid or oral preparation can simultaneously have obvious and rapid improvement effects on the three lines of the platelets, white blood cells, and red blood cells, can improve myelosuppressed chemotherapy patients in a short period of time (4 days), and avoid delays in chemotherapy cycles of the patients.

Description

Technical field: [0001] The invention relates to an oral preparation or an oral liquid, in particular to an oral preparation or an oral liquid capable of improving bone marrow hematopoietic function (simultaneously improving three lines of platelets, white blood cells and red blood cells). Background technique: [0002] my country's cancer statistics report shows that [1] In 2015, there will be more than 4,292,000 new cases of cancer in my country, and more than 2,814,000 deaths, which seriously threaten the health and lives of our people. Surgical resection is the curative treatment for most solid malignant tumors, but most postoperative patients require adjuvant chemotherapy. Chemotherapy is the most basic treatment for patients with malignant tumors at a late stage, unable to obtain radical surgical resection, and postoperative recurrence and metastasis [2-4] . Inhibition of bone marrow hematopoietic function is the most serious and basic adverse reaction of chemothera...

Claims

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Application Information

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IPC IPC(8): A61K36/296A61K9/08A61K9/10A61K47/42A61K47/02A61K9/16A61P35/00A23L33/00A23L29/30A61K135/00A61K127/00
CPCA23V2002/00A61K9/0095A61K9/16A61K36/296A61K47/02A61K47/42A23L29/30A23L33/00A61P35/00A23V2200/30A23V2250/628
Inventor 金科涛蓝欢荣
Owner 金科涛
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