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Preparation method of printable high-strength body temperature release drug hydrogel

A hydrogel, high-strength technology, applied in medical science, bandages, additive processing, etc., can solve the problems of poor biocompatibility, poor mechanical properties, lack of hydrogel, etc., and achieve a tight network and enhanced hydrophobicity Effect

Active Publication Date: 2020-08-18
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydrogel dressings are cross-linked by polymers to form a gel, which can temporarily replace the skin by creating a moist and sterilized wound healing environment. However, the current hydrogels used for skin wound repair mainly have the following problems: hydrogel lacks The design of strengthening and toughening mechanism leads to poor mechanical properties, poor wound protection effect, and no ability for the wound to resist secondary damage from external forces; the diversity of wounds is strong, and hydrogel dressings cannot be shaped into wounds.
Most antibacterial hydrogels suffer from poor mechanical properties, difficulty in free-formation, and poor biocompatibility.

Method used

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  • Preparation method of printable high-strength body temperature release drug hydrogel
  • Preparation method of printable high-strength body temperature release drug hydrogel
  • Preparation method of printable high-strength body temperature release drug hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Step 1): Weigh 2.0725g AMPS (1mol / L), 0.4g NaOH (1mol / L), 0.0616g MBAA (0.04mol / L) and 0.0015g KA (0.001mol / L) respectively in a beaker, add 10mL Deionized water, stirred evenly to obtain a transparent solution. The solution is poured into a glass mold, and placed under a high-pressure mercury lamp with a power of 200-500W at 10-30 cm for 7-10 hours to obtain PNaAMPS hydrogel.

[0036] Step 2): The hydrogel prepared in step (1) was dried in a vacuum oven at 80° C. to constant weight, ground and sieved to obtain PNaAMPS powder with a particle size of 10-200 μm.

[0037] Step 3): Weigh 0.15g PNaAMPS (0.015g / mL), 0.5658g NIPAM (0.5mol / L), 2.4878gAAm (3.5mol / L), 0.0154g MBAA (0.01mol / L) and 0.0015g KA (0.001 mol / L) into a beaker, add 10 mL of deionized water, stir evenly to obtain a translucent solution.

[0038] Step 4): Pour the solution obtained in step (3) into a glass mold, place it under a high-pressure mercury lamp with a power of 200-500W at 10-30cm for 7-10 hours...

Embodiment 2

[0045] Step 1): Weigh 2.0725g AMPS (1mol / L), 0.4g NaOH (1mol / L), 0.0616g MBAA (0.04mol / L) and 0.0015g KA (0.001mol / L) respectively in a beaker, add 10mL Deionized water, stirred evenly to obtain a transparent solution. The solution is poured into a glass mold, and placed under a high-pressure mercury lamp with a power of 200-500W at 10-30 cm for 7-10 hours to obtain PNaAMPS hydrogel.

[0046] Step 2): The hydrogel prepared in step (1) was dried in a vacuum oven at 80° C. to constant weight, ground and sieved to obtain PNaAMPS powder with a particle size of 10-200 μm.

[0047] Step 3): Weigh 0.15g PNaAMPS (0.015g / mL), 1.1316g NIPAM (1mol / L), 2.1324g AAm (3mol / L), 0.0154g MBAA (0.01mol / L) and 0.0015g KA (0.001mol / L) In a beaker, add 10 mL of deionized water, stir evenly to obtain a translucent solution.

[0048] Step 4): Pour the solution obtained in step (3) into a glass mold, place it under a high-pressure mercury lamp with a power of 200-500W at 10-30cm for 7-10 hours, and...

Embodiment 3

[0055] Step 1): Weigh 2.0725g AMPS (1mol / L), 0.4g NaOH (1mol / L), 0.0616g MBAA (0.04mol / L) and 0.0015g KA (0.001mol / L) respectively in a beaker, add 10mL Deionized water, stirred evenly to obtain a transparent solution. The solution is poured into a glass mold, and placed under a high-pressure mercury lamp with a power of 200-500W at 10-30 cm for 7-10 hours to obtain PNaAMPS hydrogel.

[0056] Step 2): The hydrogel prepared in step (1) was dried in a vacuum oven at 80° C. to constant weight, ground and sieved to obtain PNaAMPS powder with a particle size of 10-200 μm.

[0057] Step 3): Weigh 0.15g PNaAMPS (0.015g / mL), 1.6974g NIPAM (1.5mol / L), 1.7770gAAm (2.5mol / L), 0.0154g MBAA (0.01mol / L) and 0.0015g KA (0.001 mol / L) into a beaker, add 10 mL of deionized water, stir evenly to obtain a translucent solution.

[0058] Step 4): Pour the solution obtained in step (3) into a glass mold, place it under a high-pressure mercury lamp with a power of 200-500W at 10-30cm for 7-10 hours...

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Abstract

The invention discloses a preparation method of a printable high-strength body temperature release drug hydrogel. The preparation method comprises the following steps: preparing chemically crosslinkedPNaAMPS hydrogel, grinding the chemically crosslinked PNaAMPS hydrogel into powder, adding the PNaAMPS powder into a solution containing NIPAM, AAm monomers, an initiator and a crosslinking agent, directly pouring the solution into a glass mold, and carrying out polymerization molding under the illumination of ultraviolet light. The obtained hydrogel has a unique double-network structure, excellent mechanical strength, good toughness and good environmental responsiveness, and can efficiently load and release small molecular drugs in a body temperature environment to achieve an antibacterial effect. The preparation process is simple and easy to implement, the product performance is excellent, and the hydrogel has wide application prospects in the fields of bioengineering, drug controlled release, and the like.

Description

technical field [0001] The invention belongs to macromolecular materials, and specifically relates to a preparation method of a high-strength body temperature-releasing drug hydrogel that can be printed and formed. Background technique [0002] Skin wounds are usually damage to skin tissue caused by external forces. Wound repair, especially chronic wound repair (such as diabetic skin ulcers), is a worldwide problem that needs to be solved urgently. Wound exposure caused by tissue damage can easily cause bacterial adhesion, which will trigger the body's defense response (inflammatory response). Hydrogel dressings are cross-linked by polymers into gels, which can create a moist and bactericidal wound healing environment to temporarily replace the skin, but the current hydrogels used for skin wound repair mainly have the following problems: hydrogel lacks The design of the toughening mechanism leads to poor mechanical properties, poor wound protection effect, and the ability ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F265/10C08F220/54C08F220/56C08F120/58C08F2/48A61L26/00B33Y70/00
CPCC08F265/10C08F120/58C08F2/48A61L26/0014A61L26/0066A61L26/008B33Y70/00C08L33/24C08F220/54C08F220/56
Inventor 李学锋舒萌萌龙世军黄子寒陈顺兰李捷
Owner HUBEI UNIV OF TECH
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