Method for detecting multi-index component content of medicinal preparation

A detection method, a technology of pharmaceutical preparations, applied in the direction of measuring devices, material separation, analysis of materials, etc., to achieve the effect of good linear relationship, strong specificity, and accurate detection methods

Active Publication Date: 2020-08-21
SHANDONG BUCHANG SHENZHOU PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The detection method overcomes the defects of thin layer chroma

Method used

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  • Method for detecting multi-index component content of medicinal preparation
  • Method for detecting multi-index component content of medicinal preparation
  • Method for detecting multi-index component content of medicinal preparation

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0044] Example 1:

[0045] 1 Instruments and reagents

[0046] Waters 2695 High Performance Liquid Chromatography System (Waters Company); Chem Pattern 2017 pro software (Komain (Beijing) Technology Co., Ltd.). XSE205 one hundred thousandth electronic balance (METTLER company); BK-600C ultrasonic cleaner (Buck Ultrasonic Equipment Co., Ltd.).

[0047] Reference substance paeoniflorin (batch number 110736-201539, at 96.4%), rosmarinic acid (batch number 111871-201706, at 90.5%), baicalin (batch number 110715-201821, at 95.4%), salvianolic acid B (Batch number 111562-201615, calculated at 96.2%), wogonin (batch number 112002-201702, calculated at 98.5%) and paeonol (batch number 110708-201407, calculated at 99.9%) were purchased from China Institute for Food and Drug Control ;

[0048] There are 13 batches of Xiaoru Sanjie capsules (Shandong Shenzhou Buchang Pharmaceutical Co., Ltd., batch numbers 170207, 170301, 180105, 180404, 180405, 190410, 190503, 190504, 190506, 190910, 191103, ...

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Abstract

The invention provides a method for detecting the multi-index component content of a medicinal preparation. According to the detection method, an HPLC-DAD (High Performance Liquid Chromatography-Digital Analog Digital) method is adopted to simultaneously determine the content of six components including paeoniflorin, rosmarinic acid, baicalin, salvianolic acid B, wogonoside and paeonol in the medicinal preparation. The six components are adopted according to reference standards, and can reach the effects of comprehensively detecting the internal quality and stability of the medicine, and the medication safety and the effectiveness of the product are ensured.

Description

technical field [0001] The invention belongs to the field of detection and analysis of pharmaceutical components, and in particular relates to a method for detecting the content of multiple indicators of pharmaceutical preparations. Background technique [0002] The pharmaceutical preparation of the present invention is composed of sixteen medicines such as Bupleurum Radix, Radix Paeoniae Alba, Cyperi Cyperi, Prunella vulgaris, Angelica, Scutellaria Baicalensis, Salvia Miltiorrhiza and Moutan Cortex. The marketed drug prepared from the prescription of this pharmaceutical preparation is the core oral preparation product of gynecology (Xiaoru Sanjie Capsule) of Shandong Buchang Shenzhou Pharmaceutical Co., Ltd. In Chinese medicine, it is used clinically for diseases such as hyperplasia of mammary glands and distending pain of breast and bladder caused by stagnation of Qi due to stagnation of phlegm and stagnation of phlegm. The national drug approval number of this drug is Z2...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/14
CPCG01N30/02G01N30/06G01N30/14G01N2030/146
Inventor 胡孝文王明耿林永强许丽丽徐兴燕臧远芳林玉梅崔巧红李军
Owner SHANDONG BUCHANG SHENZHOU PHARMA
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