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Preparation method of controllable multi-morphology microspheres

A technology of microspheres and morphology, applied in the direction of microsphere preparation, microcapsule preparation, etc., can solve the problems of limiting the application, introduction, and cumbersome preparation methods of microspheres, and achieve the effect of simple and flexible preparation methods

Inactive Publication Date: 2020-08-28
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of these commonly used methods have defects such as complicated preparation work, cumbersome preparation methods, introduction of organic solvents and other non-purpose components, and more importantly, the current methods are difficult to prepare microspheres with complex shapes, which limits the quality of microspheres. Deeper Application

Method used

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  • Preparation method of controllable multi-morphology microspheres
  • Preparation method of controllable multi-morphology microspheres
  • Preparation method of controllable multi-morphology microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] First, take two 50mL dry screw bottles and add the prepared 2% sodium alginate solution, and then add 2% ferric oxide nanoparticles to one of the bottles, and mix the two bottles of solutions evenly, respectively as a two-phase core shell The inner and outer phases of the microspheres. Take another receiving dish without a cover, add acetic acid aqueous solution containing 2% calcium chloride and 0.15% chitosan, and the solution depth exceeds 1cm, as a receiving bath for microspheres.

[0027] then follow figure 1 and figure 2 The device for gas-assisted preparation of microspheres was constructed as shown, according to image 3 Prepare a single-core-shell type coaxial nozzle system, add 2% sodium alginate solution containing 2% ferric oxide nanoparticles into the inner phase channel at a rate of 2mL / h, and add 0.5mL / h in the outer phase channel Add a sodium alginate solution that does not contain ferric oxide nanoparticles, and then pass nitrogen gas into the outer...

Embodiment 2

[0029] First, take two 50mL dry screw-top bottles and add the prepared 2% sodium alginate solution, and then add 0.5% iron ferric oxide nanoparticles to one of the bottles, and mix the two bottles of solutions evenly, respectively as a two-phase core-shell The inner and outer phases of the microspheres. Take another receiving dish without a cover, add an aqueous solution containing 2% calcium chloride and 0.15% chitosan, and the solution depth exceeds 1 cm, as a receiving bath for the microspheres.

[0030] then follow figure 1 and figure 2 The device for gas-assisted preparation of microspheres was constructed as shown, according to Figure 4 Prepare the surrounding multi-core-shell coaxial nozzle system, add sodium alginate solution containing 0.5% ferric oxide nanoparticles at a rate of 2mL / h in the inner phase channel, and add 0.5mL sodium alginate solution in the surrounding multi-outer phase channel. The sodium alginate solution that does not contain ferric oxide nan...

Embodiment 3

[0032] First, take three 50mL dry screw bottles and add the prepared 2% sodium alginate solution, then add 2% ferric oxide nanoparticles to one bottle, and add 0.8% iron ferric oxide nanoparticles to the other bottle , the last bottle does not add iron ferric oxide nanoparticles, and the solutions in the three bottles are uniformly mixed separately, as different phases of the core-shell microspheres. Take another receiving dish without a cover, add an aqueous solution containing 2% calcium chloride and 0.15% chitosan, and the solution depth exceeds 1 cm, as a receiving bath for the microspheres.

[0033] then follow figure 1 and figure 2 The device for gas-assisted preparation of microspheres was constructed as shown, according to image 3 Prepare a single core-shell type coaxial nozzle system, add sodium alginate solution containing 0.8% iron ferric oxide nanoparticles at a rate of 1mL / h in the inner phase channel, and add 0.5mL / h of sodium alginate solution in the outer p...

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Abstract

The invention discloses a preparation method of controllable multi-morphology microspheres. The method has the advantages of favorable biocompatibility and simplicity, and can be used for preparing the microspheres with complex morphologies in one step. The microspheres with corresponding complex morphologies are obtained through a gas-assisted microsphere preparation device, two types of coaxialnozzle systems are taken as examples, microspheres with three different types of morphologies are displayed, and microspheres with controllable morphologies are obtained by adjusting multiple parameters. The whole preparation method is simple, easy to operate and environmentally friendly, the microspheres of various complex morphologies can be prepared, the microsphere material has broad spectrumand high flexibility, and important reference is provided for preparation of the microspheres of various morphologies.

Description

technical field [0001] The invention relates to a method for preparing controllable microspheres with various complex shapes in one step. Background technique [0002] The application of microspheres is extremely wide and penetrates into almost all industries: whether it is new medicine, flat panel display, food safety testing, medical diagnosis, or water treatment, energy saving and environmental protection, petrochemical industry, national defense and security, etc., are inseparable from advanced microsphere materials . The preparation methods of microspheres generally include spray drying method, electrospray method, supercritical fluid method, phase separation method, emulsion method, monomer polymerization method and microfluidic method. However, most of these commonly used methods have defects such as complicated preparation work, cumbersome preparation methods, introduction of organic solvents and other non-purpose components, and more importantly, the current method...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/04
CPCB01J13/046
Inventor 黄超伯曲清莉张建陈小琼唐国胜
Owner NANJING FORESTRY UNIV
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