Long-acting antibacterial dressing and preparation method thereof
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A long-acting, structural-type technology, applied in the field of synthetic polymer biomaterials, can solve the problems of wound secondary injury, short use time, easy loss, etc., and achieve long-lasting antibacterial effect and good skin adhesion effect
Pending Publication Date: 2020-09-04
张玉花
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Problems solved by technology
The antibacterial agent is combined with the dressing base in the form of physical blending, which is easily lost during use and cannot achieve long-term antibacterial effect
Moreover, this liquid dressing has a short service life, and frequent dressing replacement due to failure may easily cause secondary damage to the wound
Method used
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Embodiment 1
[0047] (1) Preparation of quaternary ammonium salt reactive monomer (QA)
[0048] In a three-necked flask equipped with a condensing reflux device, a constant pressure dropping funnel, a nitrogen protection device and a stirring paddle, drop into dodecyldimethyl tertiary amine (12-DMA) and twice the volume of acetone to fully stir and dissolve, and heat up to After 55°C, p-chloromethylstyrene (p-CMS) was added dropwise. After the dropwise addition was completed, the reaction was kept for 2 hours. After the reaction, the product was precipitated with n-heptane, washed 3 times with acetone, and dried in a vacuum oven at 50°C for 5 hours to obtain QA;
[0049] Wherein, the molar ratio of p-CMS to 12-DMA is 3:1.
[0050] (2) Preparation of PDMS 500 - amino 2
[0051] Octamethylcyclotetrasiloxane (D 4 ), 1,3-bis(3-aminopropyl)-1,1,3,3-tetramethyldisiloxane (BAPTMDS), tetramethylammonium hydroxide (TMAH) were put into the reaction kettle, heated React at 90°C for 9 hours, then...
Embodiment 2
[0061] Steps (1)~(3) are identical with embodiment 1
[0067] PDMS 500 -vinyl 2 , HEMA, QA, AA molar ratio is 18:20:30:20, AIBN is 0.1-0.3% of the total monomer mass.
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Abstract
The invention discloses a long-acting antibacterial dressing and a preparation method thereof. The preparation method comprises the step that a vinyl-terminated polysiloxane reaction monomer and a quaternary ammonium salt reaction monomer are prepared and subjected to free radical polymerization with acrylic acid and hydroxyethyl methacrylate, so the polysiloxane elastomer dressing with a cross-linked structure is prepared. According to the invention, a system contains a large number of polar groups (amide, carboxyl groups, hydroxyl groups and substituted ureido groups), so the elastomer dressing has good skin adhesion and percolate absorptivity; quaternary ammonium salt molecules are connected into an elastomer in a chemical crosslinking mode, so the dressing is endowed with a good and lasting antibacterial effect, and the elastomer dressing has potential application in wet dressings.
Description
technical field [0001] The invention belongs to the technical field of synthetic polymer biomaterials, and in particular relates to a skin wound dressing with long-acting antibacterial effect and a preparation method thereof. [0002] technical background [0003] According to the "moist wound healing theory", the activity of various cells, enzymes, and growth factors on the wound is low under dry conditions, but the biological activity is greatly increased in a humid environment, which can promote the growth of granulation tissue and help wound healing. Healing, but the moist environment is also a breeding ground for bacteria and fungi, so the development of moist dressings with antibacterial efficacy is an urgent practical need. [0004] Polysiloxane has good biocompatibility and is widely used in the preparation of medical products, especially skin wound dressings. CN106038065B discloses a polysiloxane elastomer dressing with a double-layer structure. The elastic layer ha...
Claims
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