Small molecular compound for inhibiting activity of AKT and STAT3 and application of small molecular compound

A small molecule compound, active technology, applied in the direction of organic active ingredients, organic chemistry, drug combination, etc., to achieve the effect of inhibiting tumor cell proliferation and eliminating tumor stem cells
CN111662288AActive Publication Date: 2020-09-15XUZHOU MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XUZHOU MEDICAL UNIV
Publication Date
2020-09-15

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Abstract

The invention provides a small molecular compound for inhibiting the activity of AKT and STAT3 and an application of the small molecular compound. The structure of the small molecular compound is shown as a compound f-5. The small molecular compound f-5 provided by the invention can inhibit the activities of AKT and STAT3 at the same time, can effectively inhibit the growth and proliferation of various glioblastoma cell strains, and prolongs the survival time of tumor-bearing mice. The compound provided by the invention has a clinical treatment value on glioblastoma and tumors depending on AKTand STAT3 pathways.
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Description

technical field

[0001] The invention belongs to the field of medicine, and specifically, the invention provides a small molecular compound for inhibiting the activity of AKT and STAT3 and application thereof. Background technique

[0002] Glioblastoma is the most malignant adult primary malignant brain tumor in the central nervous system. The current surgical methods cannot completely remove the tumor, which has the characteristics of high recurrence rate and high mortality rate. The prognosis of patients with glioblastoma is very poor, and the median survival time of patients is only 12-15 months. At present, the main treatment drug is temozolomide, but its therapeutic effect has not greatly improved the survival period of patients with glioblastoma. There is a lack of other effective therapeutic drugs, especially small molecule drugs for targeted therapy. Finding new therapeutic drugs or methods for glioblastoma to prolong the survival of patients is an urgent problem t...

Claims

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