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Diclofenac enteric-coated tablet and processing technology thereof

A technology of diclofenac and processing technology, applied in the field of diclofenac enteric-coated tablet and its processing technology, can solve problems such as affecting the qualified rate, and achieve the effect of improving the qualified rate of products

Pending Publication Date: 2020-09-25
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the proportion problem in the process of processing the existing diclofenac sodium enteric-coated tablets, the pass rate will be affected in the process of tablet processing. Therefore, we propose a diclofenac enteric-coated tablet and its processing technology

Method used

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  • Diclofenac enteric-coated tablet and processing technology thereof
  • Diclofenac enteric-coated tablet and processing technology thereof
  • Diclofenac enteric-coated tablet and processing technology thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] A diclofenac enteric-coated tablet, comprising the following raw materials in parts by weight: 25 parts of diclofenac sodium, 48 parts of lactose, 35 parts of cornstarch, 38 parts of microcrystalline cellulose, 2 parts of anhydrous silica gel, 2 parts of magnesium stearate, and cellulose vinegar 11.64 parts of French esters, 0.466 parts of polyethylene glycol, 1.242 parts of castor oil, 1.653 parts of Opadry, 2.3 parts of acetone, and 2.3 parts of dichloromethane.

[0024] A kind of processing technology of diclofenac enteric-coated tablet, following processing steps:

[0025] S1. Weigh the raw materials according to the proportion;

[0026] S2. Diclofenac sodium and cornstarch that have passed through a 30-mesh sieve are added to the mixer and mixed for 10 minutes;

[0027] S3. Add microcrystalline cellulose and lactose that have passed through a 30-mesh sieve into the mixer, and continue mixing for 10 minutes;

[0028] S4. Pass anhydrous silica gel through a 30-mesh...

Embodiment 2

[0031] A diclofenac enteric-coated tablet, comprising the following raw materials in parts by weight: 45 parts of diclofenac sodium, 54 parts of lactose, 37 parts of cornstarch, 39.6 parts of microcrystalline cellulose, 1.8 parts of anhydrous silica gel, 3.6 parts of magnesium stearate, cellulose vinegar 18.532 parts of French esters, 0.618 parts of polyethylene glycol, 1.853 parts of castor oil, 2.631 parts of Opadry, 2.8 parts of acetone, and 2.8 parts of dichloromethane.

[0032] A kind of processing technology of diclofenac enteric-coated tablet, following processing steps:

[0033] S1. Weigh the raw materials according to the proportion;

[0034] S2. Diclofenac sodium and cornstarch that have passed through a 30-mesh sieve are added to the mixer and mixed for 10 minutes;

[0035] S3. Add microcrystalline cellulose and lactose that have passed through a 30-mesh sieve into the mixer, and continue mixing for 10 minutes;

[0036] S4. Pass anhydrous silica gel through a 30-m...

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Abstract

The invention relates to the technical field of pharmaceutical preparations, and discloses a diclofenac enteric-coated tablet. The diclofenac enteric-coated tablet comprises the following raw materials in parts by weight: 25 to 45 parts of diclofenac sodium, 48 to 54 parts of lactose, 35 to 37 parts of corn starch, 38 to 39.6 parts of microcrystalline cellulose, 1.8 to 2 parts of anhydrous silicagel, 2 to 3.6 parts of magnesium stearate, 11 to 19 parts of cellulose acetate, 0.3 to 0.6 part of polyethylene glycol, 1.1 to 1.9 parts of castor oil, 1.5 to 3 parts of opadry, 2.3 to 2.8 parts of acetone, and 2.3 to 2.8 parts of dichloromethane. According to the diclofenac enteric-coated tablet and the processing technology thereof, the proportion of the raw materials is improved, the qualifiedrate of the diclofenac enteric-coated tablet is much higher than that in the prior art through a strict technology, in addition, the specific parameters of a tablet press and a coating machine are tested through a verification method in the tabletting process, and the qualified rate of processed products is increased.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a diclofenac enteric-coated tablet and a processing technology thereof. Background technique [0002] Diclofenac sodium is a non-steroidal anti-inflammatory analgesic derived from phenylacetic acid. Its mechanism of action is to inhibit the activity of cyclooxygenase, thereby blocking the transformation of arachidonic acid into prostaglandins. Tetraenoic acid combines with triglycerides to reduce the concentration of free arachidonic acid in cells, thereby indirectly inhibiting the synthesis of leukotrienes. After diclofenac sodium is added to the drug, it is made into diclofenac sodium enteric-coated tablets for anti-inflammatory. [0003] Diclofenac sodium enteric-coated tablets are used to relieve joint swelling and pain symptoms of various arthritis, treat non-articular soft tissue rheumatic pain, acute mild and moderate pain, and have antipyretic effect o...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/32A61K9/30A61K31/196A61K47/38A61K47/36A61K47/26A61K47/04A61P29/00A61P19/02
CPCA61K9/2866A61K9/282A61K9/2853A61K31/196A61K9/2059A61K9/2054A61K9/2018A61K9/2009A61P29/00A61P19/02
Inventor 高煜操铖
Owner HUAYI PHARMA ANHUI CO LTD
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