Pharmaceutical composition for regulating liver lipid metabolism

A technology of lipid metabolism and composition, applied in the field of drug research, to achieve the effect of reducing content, reducing immune response, and eliminating immune complexes

Pending Publication Date: 2020-09-29
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few effective drugs

Method used

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  • Pharmaceutical composition for regulating liver lipid metabolism
  • Pharmaceutical composition for regulating liver lipid metabolism
  • Pharmaceutical composition for regulating liver lipid metabolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The two types of active pharmaceutical ingredients or their corresponding extracts can be prepared according to the methods reported in the literature. For example, the extract of Schisandra chinensis can be decocted with crude drug Schisandra chinensis with water for 1 hour according to the method in Volume 11 of "Prescriptions of Traditional Chinese Medicine" time, 1.5 hours each time, filter, combine the filtrates, and concentrate to get final product; or according to the method in Volume 19 of "Prescriptions of Traditional Chinese Medicine", use dried and crushed Schisandra chinensis, and reflux extraction with 75% ethanol three times, the first Add 4 times the amount of 75% ethanol once, reflux for 3 hours, add 3 times the amount of 75% ethanol for the second time, reflux for 2 hours, add 3 times the amount of 75% ethanol for the third time, reflux for 1 hour, combine the extracts, and let stand After 48 hours, absorb the supernatant, recover ethanol under reduced ...

Embodiment 2

[0021] Take 10kg of Scutellaria baicalensis, add water to decoct, combine the decoction, concentrate to an appropriate amount, adjust the pH value to 1.0-2.0 with hydrochloric acid, keep warm at 80°C, let stand, filter, add appropriate amount of water to the precipitate, stir well, and add 40% sodium hydroxide Adjust the pH value to 7.0, add an equal amount of ethanol, stir to dissolve, filter, adjust the pH value of the filtrate to 1.0-2.0 with hydrochloric acid, keep warm at 60°C, let it stand, filter, and precipitate with appropriate amount of water and different concentrations of ethanol in turn Wash until the pH value reaches 7.0, evaporate the ethanol, and dry under reduced pressure to obtain baicalin flavonoids, wherein the content of baicalin is ≥90.0%.

[0022] Take 10kg of Schisandra chinensis, add water to decoct for 1 hour, filter, discard the filtrate, dry the dregs of the medicine, pulverize, extract twice with 70% ethanol for 1.5 hours each time, filter, combine ...

Embodiment 3

[0025] Take 10kg of Scutellaria baicalensis, add water to decoct, combine the decoction, concentrate to an appropriate amount, adjust the pH value to 1.0-2.0 with hydrochloric acid, keep it warm at 80°C, let it stand, filter, and dry the precipitate to obtain the Scutellaria baicalensis extract. The content of baicalin is ≥50.0%.

[0026] Take 10 kg of Schisandra chinensis, decoct with water for 1 hour, filter, discard the filtrate, dry the dregs, crush, extract twice with 70% ethanol for 1.5 hours each time, filter, combine the filtrates, and concentrate to obtain Schisandra chinensis Extract, wherein the total lignan content ≥ 10.0%.

[0027] Take the above-mentioned scutellaria baicalensis extract (equivalent to 1 kg scutellaria baicalensis) and southern Schisandra chinensis extract (equivalent to 1 kg schisandra chinensis), mix, add an appropriate amount of starch, mix evenly, granulate, pack into capsules, and make 1000 capsules to obtain the capsule doses of oral medica...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for regulating liver lipid metabolism. The pharmaceutical composition is prepared from radix scutellariae flavone and kadsura longepedunculata lignan as effective medicinal components and acceptable auxiliary additive components in the medicine, and the effective components radix scutellariae flavone and kadsura longepedunculata lignin are prepared from raw material crude drug radix scutellariae and kadsura longepedunculata at the weight ratio of 1: (0.2-5). The kadsura longepedunculata and the radix scutellariae are combined to achieve a good regulation effect on liver lipid, when the liver lipid rises, the content of the liver lipid can be remarkably reduced, the immunoreaction can be reduced, the immune complex can be eliminated, theimmunity can be regulated, and the body can be stimulated to generate interferon to improve the antiviral capacity of the body.

Description

technical field [0001] The invention relates to the field of drug research, in particular to a pharmaceutical composition for regulating liver lipid metabolism. Background technique [0002] The liver is the main site for the synthesis, catabolism, transformation, and production of sugar, fat, and protein, and plays an important role in the synthesis, decomposition, and bile acid secretion of triglyceride (TG) and cholesterol (TC). Under physiological conditions, the synthesis of triglyceride (TG) is conducive to the storage of excess free fatty acids (FFA), and TGs can exist in the liver cells in the form of lipid droplets or secreted into the blood as low-density lipoprotein (VLDL), although TGs It is the main form of lipid in the liver of many fatty liver patients, but many epidemiological studies have shown that TG can still play a protective function. In the hepatic sinusoids, hepatocytes are exposed to TG metabolites with potential toxic effects, and TG synthesis incre...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61K36/57A61P1/16C07D311/40A61K31/352
CPCA61K36/79A61K36/57A61K31/352A61P1/16C07D311/40A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 谭正怀易进海唐大轩刘云华
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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