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Bone hemostatic material for promoting new bone formation, and preparation method of bone hemostatic material for promoting new bone formation

A technology of hemostatic material and demineralized bone, which is applied in the fields of pharmaceutical formulation, pharmaceutical science, drug delivery, etc., can solve the problems of unsuitability for large-scale production, the adhesiveness needs to be improved, and the texture of bone wax is not delicate, so as to be convenient for clinical use. , convenient for mass production, and the effect of improving the convenience of use

Inactive Publication Date: 2020-09-29
SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, medical calcium salt has improved the clinical disadvantages of bone wax that is not delicate, soft, and difficult to apply. However, the preparation method of this hemostatic material for bone wounds is complicated, and it is not suitable for large-scale production, and its adhesion still needs to be improved.

Method used

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  • Bone hemostatic material for promoting new bone formation, and preparation method of bone hemostatic material for promoting new bone formation
  • Bone hemostatic material for promoting new bone formation, and preparation method of bone hemostatic material for promoting new bone formation
  • Bone hemostatic material for promoting new bone formation, and preparation method of bone hemostatic material for promoting new bone formation

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Experimental program
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Effect test

Embodiment 1

[0064] Embodiment 1: Preparation of decalcified bone particles

[0065] Bovine femur was crushed to make natural bone powder with a particle size of no more than 50 μm, which was ultrasonically cleaned 3 times with 5 times the amount (weight ratio) of purified water for 10 minutes each time; then the cleaned natural bone powder Soak in 3 times the amount (weight ratio) of absolute ethanol for 2 hours, 1 times the amount (weight ratio) of ether for 2 hours, and wash 5 times with 5 times the amount (weight ratio) of purified water; After decalcification treatment with 0.6 mol / L hydrochloric acid aqueous solution for 24 hours, the decalcified bone particles were prepared after 5 times the amount (weight ratio) of purified water was used to wash 3 times, and ventilated and dried at room temperature for 12 hours.

Embodiment 2

[0066] Embodiment 2: Preparation of decalcified bone particles

[0067] The natural bone was crushed to make a natural bone powder with a particle size not greater than 200 μm, and 20 times the amount (weight ratio) of purified water was used for ultrasonic cleaning 6 times, each time for 5 minutes; then the cleaned natural bone powder was sequentially washed with 10 Double the amount (weight ratio) of absolute ethanol for 0.5 hours, 3 times the amount (weight ratio) of ether for 0.5 hours, 20 times the amount (weight ratio) of purified water and rinse 3 times; use 1 times the amount (weight ratio) of 0.6 mol / L of hydrochloric acid aqueous solution for 72 hours after decalcification treatment, washed again 3 times with 20 times the amount (weight ratio) of purified water, and dried in a fume hood for 20 hours to prepare decalcified bone particles.

Embodiment 3

[0068] Embodiment 3: Preparation of decalcified bone particles

[0069] The natural bone was crushed to make a natural bone powder with a particle size of no more than 100 μm, which was ultrasonically cleaned with 10 times the amount (weight ratio) of purified water for 5 times, each time for 7 minutes; Double the amount (weight ratio) of absolute ethanol for 1 hour, 2 times the amount (weight ratio) of ether for 1.5 hours, 10 times the amount (weight ratio) of purified water and rinse 4 times; use 2 times the amount (weight ratio) of 0.6 mol / L hydrochloric acid aqueous solution for decalcification for 48 hours, washed again with 3 times the amount (weight ratio) of purified water for 5 times, and dried in a fume hood for 30 hours to prepare decalcified bone particles.

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Abstract

The invention provides a bone hemostatic material for promoting new bone formation. The bone hemostatic material for promoting new bone formation is prepared from ingredients in parts by weight of 10-60 parts of decalcified bone granules, 10-65 parts of hemostatic substrates and 3-60 parts of dispersed components. The bone hemostatic material disclosed by the invention has favorable biocompatibility, can be degraded and absorbed in vivo, does not have immunogenicity, and is high in safety, simple in preparation process and convenient in mass production.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a bone hemostatic material for promoting new bone formation and a preparation method thereof. Background technique [0002] Human bones are rich in blood supply, trauma and surgery of the skeletal system are faced with the problem of bone wound hemostasis, which involves departments such as brain surgery, orthopedics, thoracic surgery, maxillofacial plastic surgery, etc. Clinically, bone wound hemostatic materials are required to have a suitable viscosity , fineness, toughness, high melting point, random plasticity and acceptable pressure at room temperature and many other characteristics, according to the clinical requirements for bone wound hemostasis. At present, bone wax is commonly used clinically as a hemostasis for bone wound bleeding. Bone wax is mainly composed of beeswax, paraffin, medical vaseline, lanolin, vegetable oil, etc. It has a large c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/20A61L27/58A61L27/50
CPCA61L27/3608A61L27/365A61L27/3687A61L27/20A61L27/58A61L27/50A61L2400/04A61L2430/02
Inventor 徐宝艳李艳婷田珍黄文涛
Owner SHAANXI BIO REGENERATIVE MEDICINE CO LTD