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A kind of antibacterial polymer polyvinyl alcohol material and its method and application

A technology of polyvinyl alcohol and polymers, applied in pharmaceutical formulations, antifouling/underwater coatings, prostheses, etc., can solve problems such as infection, achieve adhesion promotion, long-lasting excellent antibacterial activity, avoid cytotoxic reactions and protein Adsorption effect

Active Publication Date: 2021-12-28
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide an antibacterial polymer polyvinyl alcohol material and its method and application, which solves the problem of postoperative infection in the existing implant materials, has excellent antibacterial activity and good biocompatibility, and at the same time, polymerizes The mechanical strength of the material coating surface has the physical stimulation effect of promoting the directional differentiation of bone marrow mesenchymal stem cells into bone cells, and can be used as a bone repair implant material

Method used

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  • A kind of antibacterial polymer polyvinyl alcohol material and its method and application
  • A kind of antibacterial polymer polyvinyl alcohol material and its method and application
  • A kind of antibacterial polymer polyvinyl alcohol material and its method and application

Examples

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Embodiment 1

[0040] A kind of preparation method of polyvinyl alcohol modified by TP / CA group, its synthetic route is:

[0041]

[0042] The specific steps are:

[0043] (S1) Polyvinyl alcohol (PVA, 250mg; n=135) was reacted with succinic anhydride (35mg) in dimethylsulfoxide (DMSO, 30mL) and triethylamine (TEA, 0.1mL) was added to obtain 10% The PVA-COOH polymer of COOH realizes the transformation of 10% of the hydroxyl groups in PVA into carboxyl groups;

[0044](S2) Add 1-ethyl-(3-dimethylaminopropyl)carbodiimide to PVA-COOH polymer (500 mg) and amino-derivatized terpyridine (TP, 139 mg) in DMSO (30 mL) Hydrochloride (EDC·HCl, 87mg) and 4-dimethylaminopyridine (DMAP, 56mg) were subjected to amidation reaction to obtain a PVA-TP-COOH polymer containing 4% terpyridine, so that 4% of carboxyl groups could pass through Amine coupling reaction and TP conjugation;

[0045] (S3) PVA-TP-COOH polymer (299mg) and dopamine hydrochloride (780mg) in dimethylformamide / MES buffer solution (DMF / M...

Embodiment 2

[0048] A kind of preparation method of antibacterial polymer polyvinyl alcohol material, such as figure 1 Shown is the synthetic route of the antibacterial macromolecular polyvinyl alcohol material of the present invention and its schematic diagram of antibacterial and cell proliferation differentiation, the method comprising:

[0049] (S10) Dissolving the PVA-TP-CA polymer prepared in Example 1 in methanol to prepare a 3 mg / mL PVA-TP-CA polymer solution;

[0050] (S20) Put six 1cm*1cm silicon wafers (silicon wafers) in two small Petri dishes, add 1mL of the PVA-TP-CA polymer solution prepared in step (S10) to the Petri dishes, and then add 2mL of pH8 .4 MOPs (3-morpholine propanesulfonic acid) buffer solution, the mixed solution was static for 4h;

[0051] (S30) Take out the silicon chip, wash it three times with double distilled water, and dry it with nitrogen to prepare a silicon chip containing a PVA-TP-CA polymer coating, forming a dense and uniform PVA-TP-CA polymer on ...

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Abstract

The invention discloses an antibacterial macromolecular polyvinyl alcohol material, a method and an application thereof. The antibacterial macromolecular polyvinyl alcohol material uses a silicon chip as a base material, and prepares a PVA-TP-CA polymer coating on the silicon chip. The polymer coating further introduces Co 2+ Ion, which has the structural formula shown in formula (1). The material of the present invention forms Co 2+ ion‑terpyridine complexes, the terpyridine group provides a platform for the efficient anchoring of bioactive cobalt ions with good control over the introduced Co 2+ The concentration of ions avoids the cytotoxic reaction and protein adsorption induced by high concentrations of metal ions, and ensures that Co 2+ The ions are stably fixed on the surface of the material to avoid being released into liquid matrices such as cell culture fluid. co 2+ The ions can provide long-term antibacterial ability on the surface of the material and improve the mechanical strength of the polymer coating surface, thereby having a physical stimulation effect of promoting the directional differentiation of bone marrow mesenchymal stem cells into bone cells.

Description

technical field [0001] The invention relates to a high-molecular polyvinyl alcohol material, in particular to an antibacterial high-molecular polyvinyl alcohol material, a method and an application. Background technique [0002] The rapid increase in the development and production of implantable devices in modern medical treatments has revealed an urgent need for these materials with additional chemical and physical properties. The physical and chemical properties of the material will inevitably directly affect the healing of the tissue, and the environment of the body will also act on the surface of the material and have an impact on the material. [0003] Therefore, the introduction of functional components on implant materials will endow these materials not only as simple scaffold materials, but also to further realize biological functions such as wound repair, damaged tissue reconstruction, and bone repair, and to achieve broader applications in tissue engineering. pros...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F16/06C08F8/32C08F8/14C09D129/04C09D5/14A61L27/30A61L27/34A61L27/50A61L27/54
CPCC08F8/32C09D129/04C09D5/14A61L27/34A61L27/306A61L27/50A61L27/54A61L2430/02A61L2300/404A61L2300/102A61L2400/18A61L2420/02A61L2420/04A61L2300/602C08L29/04C08F8/14C08F16/06
Inventor 高玲燕郑波
Owner NORTHWEST UNIV
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