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LE CAO SHI FANG extract and application thereof to liver protection

An extract and compound traditional Chinese medicine technology, applied in the field of pharmaceutical product research and development, can solve the problems of ineffectiveness, relapse of drug diseases, side effects, etc., and achieve the effect of reducing content, increasing SOD activity, and improving liver cell steatosis

Pending Publication Date: 2020-10-02
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, although some drugs for the prevention and treatment of liver damage have been developed, long-term use may have limited curative effect or serious side effects. Many drugs may relapse after stopping the drug, and have no real therapeutic effect.

Method used

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  • LE CAO SHI FANG extract and application thereof to liver protection
  • LE CAO SHI FANG extract and application thereof to liver protection
  • LE CAO SHI FANG extract and application thereof to liver protection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Recipe: 50g mouse bougainvillea, 20g Paimoensis, 30g piercing stone

[0022] (1) According to the above-mentioned formula quantity, pulverize the arborescens, the grass of the penis, and the crushed stone to 20-100 mesh and mix to obtain the material;

[0023] (2) After soaking the material obtained in step (1) with water (1000g) for 1h, reflux extraction for 3h, filter and collect the extract, filter residue and then reflux extract with water (800g) for 2h, combine the two extracts, and concentrate to a concentration of 1g / mL crude drug amount, bottling, sealing, promptly obtains described compound Chinese medicine extract (hereinafter referred to as extract A, and its fingerprint spectrum sees figure 1 ).

Embodiment 2

[0025] Recipe: 50g mouse bougainvillea, 20g Paimoensis, 30g piercing stone

[0026] (1) According to the above-mentioned formula quantity, pulverize the arborescens, the grass of the penis, and the crushed stone to 20-100 mesh and mix to obtain the material;

[0027] (2) The material obtained in step (1) is soaked in water (1000g) for 3h, then refluxed for 2h, and the extract is collected by filtration, and the filter residue is then refluxed with water (800g) for 1.5h, and the two extracts are combined and concentrated to a concentration of 1g / mL crude drug amount, bottling, sealing, promptly obtains described compound Chinese medicine extract (hereinafter referred to as extract B, fingerprint and figure 1 consistent).

Embodiment 3

[0029] Recipe: 40g mouse bougainvillea, 10g pachymos, 20g piercing stone

[0030] (1) According to the above-mentioned formula quantity, pulverize the arborescens, the grass of the penis, and the crushed stone to 20-100 mesh and mix to obtain the material;

[0031] (2) After soaking the material obtained in step (1) with water (700g) for 1h, reflux extraction for 3h, filter and collect the extract, and filter the residue for reflux extraction with water (560g) for 2h, combine the two extracts, and concentrate to a concentration of 1g / mL crude drug amount, bottled and sealed to obtain the compound Chinese medicine extract (hereinafter referred to as extract C).

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PUM

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Abstract

The invention relates to a LE CAO SHI FANG extract and application thereof to liver protection. A preparation method for the LE CAO SHI FANG extract includes the following steps: (1) in parts by weight, crushing and evenly mixing herba silybi mariani, ramulus et folium phyllodii pulchelli and radix cudraniae to obtain a material; (2) soaking the material obtained in the step (1) with water for 1-3h, then performing reflux extraction for 2-3h, filtering and collecting an extracting solution, performing reflux extraction on filter residues with water for 1.5-2h, merging extracting solutions of two times, concentrating to the crude drug amount with concentration of 1g / mL, and performing bottling and sealing to obtain the LE CAO SHI FANG extract.

Description

technical field [0001] The invention belongs to the technical field of research and development of pharmaceutical products. The invention relates to a bougainvillea stone extract and its application in liver protection. Background technique [0002] The liver is the largest substantial organ in the body, which undertakes the important functions of digestion, metabolism, detoxification and secretion of the human body, and plays an important protective role in the body. Liver injury is a common liver disease, often accompanied by metabolic and synthetic dysfunction, leading to serious diseases such as liver fibrosis, cirrhosis, hepatitis, and even liver cancer, which seriously affects human health. Acute liver injury is a common clinical liver disease. In mild cases, it manifests as elevated serum transaminases and bilirubin, which can lead to chronic hepatitis, liver failure, hepatic encephalopathy and other liver diseases. Studies have shown that acute liver injury may be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P1/16
CPCA61K36/19A61K36/48A61K36/60A61K2236/331A61K2236/39A61K2236/51A61P1/16A61K2300/00
Inventor 王长云邵长伦信兰婷乐世俊任夏赵庆张梦启
Owner OCEAN UNIV OF CHINA
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