Hydrophilic polyurethane foam dressing and preparation method thereof

A technology of hydrophilic polyurethane and foam, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of polyurethane foam dressings such as difficulty in sustaining hydrophilicity, reduced mechanical properties, and weak bonding, so as to achieve abundant reserves and reduce production Cost, low cost effect

Active Publication Date: 2020-10-09
WUHAN RUIFA MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above-mentioned polyurethane foam dressings all improve their hydrophilicity by adding hyaluronic acid or sodium alginate to the polyurethane prepolymer, but due to the relatively weak binding effect between the added hyaluronic acid or sodium alginate and the polyurethane prepolymer Weak, it is easy to lose during actual use, making it difficult to sustain the hydrophilicity of polyurethane foam dressings, and reducing its mechanical properties, resulting in limited application
In addition, the polyols currently used in the production of polyurethane foam dressings are mainly petroleum-based polyols. Since such polyols usually have problems such as high cost, difficulty in degradation, and environmental pollution, how to use cheaper and environmentally friendly vegetable oil-based polyols? Alcohol replacement has gradually become a current research hotspot

Method used

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  • Hydrophilic polyurethane foam dressing and preparation method thereof
  • Hydrophilic polyurethane foam dressing and preparation method thereof
  • Hydrophilic polyurethane foam dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] The invention provides a preparation method of a hydrophilic polyurethane foam dressing, comprising the following steps:

[0028] S1, mix the vegetable oil-based polyol and polyethylene glycol uniformly according to a preset mass ratio to obtain a polyol mixed solution; then add a predetermined amount of foaming agent, catalyst, surfactant and filler to the polyol mixed solution, After heating and stirring and fully mixing, mixed solution I was obtained;

[0029] S2. The mixed solution I obtained in step S1 is left to stand, and after the bubbles are removed, polyisocyanate is added according to the preset isocyanate index, and the mixed solution II is obtained after stirring rapidly to make it evenly mixed; II is poured into the mold, and then fully reacted and then cured to obtain a hydrophilic polyurethane foam dressing.

[0030] In step S1, the preset mass ratio of the vegetable oil-based polyol and polyethylene glycol is 1:(0.8-1.2).

[0031] In step S1, the amou...

Embodiment 1

[0041] Embodiment 1 provides a preparation method of a hydrophilic polyurethane foam dressing, comprising the following steps:

[0042] S1, weigh each 35g of soybean oil-based polyol and polyethylene glycol in a mass ratio of 1:1, place in a clean plastic cup, and mix well to obtain a polyol mixture; then weigh 1.68g of distilled water (foaming agent) ), 0.7g triethylenediamine (catalyst), 0.7g silicone oil (surfactant) and 0.07g sodium hyaluronate (filler), mix them evenly and add them to the polyol mixture, at 65°C Stir for 5min, make it mix uniformly, obtain mixed solution I.

[0043] S2, the described mixed solution I obtained in step S1 is left standing for 2min to remove air bubbles, then calculate and weigh 37.95g polyisocyanate according to the isocyanate index of 1.2, this polyisocyanate is composed of 80% of 2,6-toluene diisocyanate and 20 % of 4,4'-diphenylmethane diisocyanate; after adding the polyisocyanate into the mixed solution I, rapidly stirring for 8s at a ...

Embodiment 2～3 and comparative example 2

[0051] Examples 2 to 3 and Comparative Example 2 respectively provide a preparation method of a hydrophilic polyurethane foam dressing. Compared with Example 1, the difference is that the addition amount of sodium hyaluronate as a filler in step S1 is changed. , the specific sodium hyaluronate addition amount corresponding to each embodiment and the comparative example and its mass percentage in the polyol mixed solution are shown in Table 1; the remaining steps are the same as in Example 1, and will not be repeated here.

[0052] The addition amount of sodium hyaluronate and its proportion of table 1 embodiment 2~3 and comparative example 2

[0053]

[0054] In order to further evaluate the performance of the hydrophilic polyurethane foam dressings prepared in the above examples and comparative examples, their apparent density, water absorption and moisture retention were tested respectively, and the results are shown in Table 2.

[0055] Table 2 Performance parameters of ...

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Abstract

The invention discloses a hydrophilic polyurethane foam dressing and a preparation method thereof. Vegetable oil-based polyol and polyethylene glycol are mixed in proportion, filler and auxiliaries are added, polyisocyanate is added for reaction after the filler and the auxiliaries are evenly mixed, and the hydrophilic polyurethane foam dressing which is good in biocompatibility, high in biological adhesion, safe, non-toxic, high in hydrophilicity and capable of preserving moisture for a long time is prepared. Through the mode, the polyurethane foam dressing prepared by mixing the vegetable oil-based polyol and the polyethylene glycol can reach proper hydrophilicity under the condition of low cost; the excellent hydrophilicity and the combination effect of the filler can be fully utilized,the loss of the filler is avoided while the mechanical property of the polyurethane foam dressing is improved, and the long-acting moisturizing effect is achieved. Meanwhile, the whole preparation process of the hydrophilic polyurethane foam dressing is simple in process and low in cost, and can meet the requirements of industrial large-scale production.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a hydrophilic polyurethane foam dressing and a preparation method thereof. Background technique [0002] As the largest organ of the human body, the skin plays an important role in sensing external stimuli, regulating body temperature, regulating water evaporation loss, protecting various tissues and organs in the body from physical and chemical damage, and resisting the invasion of pathogenic microorganisms. When the skin is damaged in a large area, it will cause many local and even systemic problems, and even life-threatening in severe cases. Therefore, it is extremely important to cover the surface of the skin with medical dressings for repair in the case of large-area defects or difficult to heal. [0003] Medical dressings are medical hygienic materials used to temporarily cover the surface of various wounds and wounds. They can be used as a temporary substitute f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/65C08G18/64C08G18/48C08G18/36A61L15/26A61L15/42C08G101/00
CPCC08G18/6696C08G18/6547C08G18/6484C08G18/4833C08G18/4081C08G18/36A61L15/425A61L15/42A61L15/26C08L75/14
Inventor 余曾成张磊王业富
Owner WUHAN RUIFA MEDICAL DEVICES CO LTD
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