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Hydroxypropyl tetrahydropyranitol compound and preparation method and application thereof

A technology of hydroxypropyltetrahydropyrantriol and compound, which is applied in the biological field, can solve the unscientific ratio relationship, without mentioning the synergistic effect and quantity of hydroxypropyltetrahydropyrantriol compound Ratio relationship and synergistic effect, difficulty in synergy and other issues, to achieve the effect of improving moisturizing, moisturizing and anti-aging effects, and positive effects

Pending Publication Date: 2020-10-16
贝乐科(上海)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] As far as the existing technology is concerned, the nursing products currently on the market cannot effectively and quickly strengthen the connection between the epidermis and the dermis, nor can they enhance the ability of fibroblasts to extracellular matrix such as collagen, proteoglycan, glycosaminoglycan, etc. From the perspective of sugar expression and content, it can significantly improve skin elasticity and skin firmness to achieve skin anti-aging functions
Usually, the ingredients in the formula are added through simple or random compatibility, or the unscientific ratio relationship is used when a single ingredient is used or used in combination, so it is difficult to give full play to its multifunctionality and synergy of efficacy
In the Chinese invention patent application document with the publication number CN110302086A, a multi-effect repair essence and its preparation process are disclosed, including hydrolyzed sodium hyaluronate, sodium hyaluronate and hydroxypropyltetrahydropyrantriol, etc., but It also only involves the synergistic effect of hydroxypropyltetrahydropyrantriol, small molecule tripeptide and carboxymethyl β-glucan sodium when used in combination, and does not involve hydroxypropyltetrahydropyrantriol Synergistic effect of alcohols with different molecular weight hyaluronic acid and / or salts and hyaluronic acid precursor substance acetylglucosamine, not to mention hydroxypropyltetrahydropyrantriol, hyaluronic acid and / or salts with Synergistic effect, ratio relationship and synergistic effect of collagen and hydrolyzed collagen

Method used

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  • Hydroxypropyl tetrahydropyranitol compound and preparation method and application thereof
  • Hydroxypropyl tetrahydropyranitol compound and preparation method and application thereof
  • Hydroxypropyl tetrahydropyranitol compound and preparation method and application thereof

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preparation example Construction

[0057] According to a typical embodiment of the present invention, a preparation method of a hydroxypropyltetrahydropyrantriol compound is provided, the hydroxypropyltetrahydropyrantriol compound prepared by the method, each component according to The mass percentage is: 5.0%-10.0% of hydroxypropyltetrahydropyranotriol, 5%-10% of dihydric alcohol, 0.2-0.4% of p-hydroxyacetophenone, and 81%-88% of deionized water. The preparation method Include the following steps:

[0058] S101: In the emulsification tank, prepare a 5.0%-10.0% hydroxypropyltetrahydropyrantriol compound solution;

[0059] S102: Stir the hydroxypropyltetrahydropyranotriol complex solution, and add 5%-10% dihydric alcohol, 0.2-0.4% p-hydroxyacetophenone, and 81%-88% deionized water,

[0060] Thus, 5.0%-10.0% hydroxypropyltetrahydropyrantriol compound A was obtained.

[0061] According to a typical embodiment of the present invention, a preparation method of a hydroxypropyltetrahydropyrantriol compound is provid...

Embodiment 1

[0174] A compound of hydroxypropyltetrahydropyranotriol, each component by mass percentage is:

[0175] Hydroxypropyltetrahydropyranotriol 8%, high molecular weight sodium hyaluronate 0.4%, low molecular weight sodium hyaluronate 0.9%, hydrolyzed sodium hyaluronate 0.4%, acetylglucosamine 4.0%, glycol 9% , 0.3% of p-hydroxyacetophenone, and the balance is deionized water. The sum of the mass percentages of the above components is 100%.

Embodiment 2

[0177] A compound of hydroxypropyltetrahydropyranotriol, each component by mass percentage is:

[0178] Hydroxypropyltetrahydropyranotriol 10%, High Molecular Sodium Hyaluronate 0.3%, Low Molecular Hyaluronic Acid 0.8%, Hydrolyzed Hyaluronic Acid 0.1%, Propylene Glycol 5%, Hexylene Glycol 1%, Pentylene Glycol 3 %, 0.4% p-hydroxyacetophenone, 0.5% collagen, 2.0% hydrolyzed collagen, 3.0% acetylglucosamine, and the balance is deionized water. The total mass percentage of the above components is 100%.

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Abstract

The invention discloses a hydroxypropyl tetrahydropyranitol compound and a preparation method and application thereof. The hydroxypropyl tetrahydropyranitol compound comprises hydroxypropyl tetrahydropyranitol, hyaluronic acid and / or salts thereof, hydrolyzed hyaluronic acid and / or salts thereof, acetyl chitin (hyaluronic acid precursor), deionized water and a component with a preservative effector a preservative. The compound is capable of strengthening the connection between epidermis and dermis of skin, thereby improving the expression and content of fibroblast in dermis to extracellular matrix, such as collagen, proteoglycan and glycosaminoglycan and improving the skin elasticity and the skin firmness to achieve the anti-aging function of the skin. Through the addition of a certain proportion of low-content hyaluronic acid and / or salts thereof, hydrolyzed hyaluronic acid and / or salts thereof and acetyl chitin (hyaluronic acid precursor) into the compound of employing the hydroxypropyl tetrahydropyranitol as a main component, and through an appropriate proportion, the cooperativity of various components in efficacy can be put into a full play, and a moisturizing function, an anti-aging function and other functions of the components for skin care are developed to a greater extent.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the components and ratio, preparation method and application of hydroxypropyl tetrahydropyrantriol compound. Background technique [0002] In the field of cosmetics, moisturizing and anti-aging are the two main demands of skin care. Usually, hyaluronic acid or its salts are widely used as film-forming and moisturizing agents. Collagen is usually used for moisturizing and improving skin elasticity. related formulations. [0003] As far as the existing technology is concerned, the nursing products currently on the market cannot effectively and quickly strengthen the connection between the epidermis and the dermis, nor can they enhance the ability of fibroblasts to extracellular matrix such as collagen, proteoglycan, glycosaminoglycan, etc. From the perspective of sugar expression and content, it can significantly improve skin elasticity and skin firmness to achieve skin anti-aging fun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/73A61K8/65A61Q19/00A61Q19/08
CPCA61K8/498A61K8/735A61K8/736A61K8/65A61Q19/00A61Q19/08A61K2800/5922A61K2800/78
Inventor 宁继彬
Owner 贝乐科(上海)生物科技有限公司
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