Check patentability & draft patents in minutes with Patsnap Eureka AI!

Composition comprisng 2,3-butanediol as active ingredient

A butanediol and composition technology, which is applied in the field of compositions containing 2,3-butanediol as an active ingredient, can solve the problems of high cost, difficulty in separating isomers, restrictions on the use of 2,3-butanediol, etc. problem, achieve the effect of enhancing anti-inflammation, improving wrinkle, excellent anti-inflammatory effect

Pending Publication Date: 2020-10-16
GS CALTEX CORP
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of 2,3-butanediol is limited due to the high cost of the manufacturing process, environmental pollution, and difficulty in isomer separation.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition comprisng 2,3-butanediol as active ingredient
  • Composition comprisng 2,3-butanediol as active ingredient
  • Composition comprisng 2,3-butanediol as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0080] 1) Experimental Example 1: Evaluation of the anti-inflammatory effect of 2,3-butanediol

[0081] The anti-inflammatory effect was judged by the NO (Nitiric Oxide) production inhibition rate when RAW264.7 cells were treated with LPS (Lippopolysaccharide, NO production-inducing substance).

[0082] In order to evaluate the anti-inflammatory effect of 2,3-butanediol, the NO production inhibition rate was determined using Griess reagent assay. Specifically, the NO production inhibition rate was measured by the following formula 1.

[0083] [Formula 1]

[0084] NO production inhibition rate (%)=[(absorbance of sample treated group-absorbance of sample untreated group) / (absorbance of negative control group-absorbance of sample untreated group)]×100

[0085] i) Sample untreated group: group treated with culture solution

[0086] ii) Sample treatment group: the group treated with samples of different concentrations diluted with culture medium and LPS

[0087] iii) Negative ...

experiment example 2

[0092] 2) Experimental example 2: Evaluation of the antioxidant effect of 2,3-butanediol

[0093] To evaluate the antioxidant effect of 2,3-butanediol, the free radical scavenging activity was measured using DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Specifically, the antioxidant rate was calculated by the following formula 2.

[0094] [Formula 2]

[0095] Antioxidant rate (%)=[(absorbance of sample treatment group-absorbance of sample untreated group) / (absorbance of negative control group-absorbance of sample untreated group)]×100

[0096] i) Sample untreated group: a group in which ultrapure water and methanol were reacted

[0097] ii) Sample treatment group: a group in which samples of different concentrations were reacted with DPPH

[0098] iii) Negative control group: a group in which ultrapure water was reacted with DPPH

[0099] According to the concentrations described in Table 2 below, samples were prepared by diluting diol with methanol solvent, and the absorban...

experiment example 3

[0104] 3) Experimental example 3: Evaluation of wrinkle-improving effect of 2,3-butanediol

[0105] The wrinkle-improving effect of 2,3-butanediol was evaluated as the effect of reducing collagenase (eg, MMP-1) in the skin and inhibiting the decomposition of interstitial collagen (Interstitial Collagen, etc.).

[0106] In order to evaluate the wrinkle-improving effect of 2,3-butanediol, 2R,3S-butanediol, 2R,3R-butanediol, 1,3-butanediol and 1 , 3-propanediol diluted Dulbecco's Modified Eagle Medium (Gibco) 99mL and penicillin-streptomycin (Gibco) 1mL serum-free medium.

[0107] [table 3]

[0108]

[0109] In addition, cells CCD-986SK (ACTT CRL-6323 TM ) into the orifice plate with 1mL per well, and dispense to 5×10 4 , at 37°C in 5% CO 2 culture medium for 24 hours. Replace the cultured cells with the medium of Examples and Comparative Examples at 37°C in 5% CO 2 culture medium for 48 hours.

[0110] The cell lysate was recovered and the protein content was measured ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Embodiments of the present invention provide a composition comprising 2,3-butanediol as an anti-inflammatory, anti-oxidative or anti-wrinkle active ingredient. 2,3-butanediol can be used as an activeingredient of a pharmaceutical or cosmetic composition.

Description

technical field [0001] The present invention relates to a composition comprising 2,3-butanediol as an active ingredient. More specifically, it relates to a composition containing 2,3-butanediol as an anti-inflammatory, wrinkle-improving or anti-oxidative active ingredient. Background technique [0002] 2,3-butanediol (2,3-butanediol) can be industrially produced, for example, by a continuous chemical catalytic process using C-4 olefins, and can be effectively used as industrial preparations such as fuel additives, antifreeze, and plasticizers. However, the use of 2,3-butanediol is limited due to problems such as high cost of the manufacturing process, environmental pollution, and difficulty in isomer separation. [0003] Recently, a process for producing 2,3-butanediol as a bio-base has been developed, and a low-cost, environmentally friendly production process for 2,3-butanediol is being studied. Thereby, the possibility that the commercial use of 2,3-butanediol can be ex...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A61K36/47A61K35/74A61K8/34A61K8/9789A61K8/99A61P29/00A61P17/00A61Q19/08
CPCA61P17/00A61K31/047A61K35/74A61K8/9789A61K8/99A61K36/47A61Q19/08A61P29/00A61K8/345A61K2800/85A61P17/18A61Q19/00C12P7/18A61K2236/19A61K2800/522A61P39/06
Inventor 宋孝鹤朴钟明全商晙申友均
Owner GS CALTEX CORP
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com