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Zeolite imidazolate skeleton structure/metal oxide/molybdenum sulfide composite material, and preparation and application thereof

A technology of zeolite imidazolate and framework structure, which is applied in the fields of nanomaterials and electrochemical sensing, can solve problems such as difficult to solve selective capture and high-sensitivity detection, and achieves a simple and easy method, large specific surface area, and high electrocatalytic activity. Effect

Active Publication Date: 2020-10-20
SHANGHAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it is still difficult to solve the selective capture and high-sensitivity detection of the analyte by electrochemical biosensors simply by functionalizing metal oxides on the surface of thin-layer molybdenum sulfide materials.

Method used

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  • Zeolite imidazolate skeleton structure/metal oxide/molybdenum sulfide composite material, and preparation and application thereof
  • Zeolite imidazolate skeleton structure/metal oxide/molybdenum sulfide composite material, and preparation and application thereof
  • Zeolite imidazolate skeleton structure/metal oxide/molybdenum sulfide composite material, and preparation and application thereof

Examples

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Effect test

Embodiment 1

[0029] In this embodiment, a zeolite imidazolate framework structure / transition metal oxide / molybdenum sulfide composite material is based on a layered molybdenum sulfide material. First, a transition metal oxide is grown on the surface of the molybdenum sulfide material, and then the transition Zeolite imidazolate framework materials (ZIFs) were grown on the surface of metal oxides to form a composite structure.

[0030]In this embodiment, the preparation method of the zeolite imidazolate framework structure / transition metal oxide / molybdenum sulfide composite material, the steps are as follows:

[0031] a. Weigh 5 mg of pre-prepared layered MoS 2 Added to 25mL of absolute ethanol, after ultrasonic treatment for 30min, uniformly dispersed MoS 2 Solution, use a pipette gun to evenly deposit the dispersion solution on the surface of a clean silicon wafer, and wait for it to dry to form a molybdenum sulfide film;

[0032] b. Prepare a zinc acetate absolute ethanol solution with...

Embodiment 2

[0039] This embodiment is basically the same as Embodiment 1, especially in that:

[0040] In this example, the zeolite imidazolate framework material (ZIF-90) / ZnO / molybdenum sulfide composite material is used for the detection of exosome-associated antibody CD-63 (tetraspanner), and the specific steps are as follows:

[0041] ZIF-90 / ZnO / MoS 2 The preparation method of the electrochemical sensor chip modified by the composite material and the detection method of CD-63 are the same as the first embodiment. Based on ZIF-90 / ZnO / MoS 2 The detection results of the electrochemical immunosensor made of composite materials for different concentrations of CD-63 are shown in the attached image 3 shown. It can be seen from the figure that as the concentration of CD-63 gradually increased from 0.2 μg / mL to 2.0 μg / mL, the ZIF-90 / ZnO / MoS 2 The differential pulse voltammetry response signal of the composite-modified electrochemical sensor chip was enhanced accordingly. The above two sp...

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Abstract

The invention discloses a zeolite imidazate skeleton structure / metal oxide / molybdenum sulfide composite material, and preparation and application thereof. According to the composite material, a layered molybdenum sulfide material is used as a substrate, a metal oxide grows on the surface of the substrate, and then a zeolite imidazate skeleton structure material grows on the surface of the metal oxide. Layered molybdenum sulfide has an adjustable band gap structure and a plurality of physicochemical properties such as large specific surface area, high electrocatalytic activity, good biocompatibility, easy functionalization and the like; a new active space is formed between two-dimensional molybdenum sulfide layers by virtue of the supporting effect of the metal oxide, so that a transportation channel is provided for biological small molecules; the effective contact area with molecules to be detected is increased, and the electron transfer and substance transfer rate of the surface of anelectrode is increased; the zeolite imidazate skeleton structure material is used for selectively immobilizing a recognition antibody or antigen, so that high-sensitivity and specific detection of anantigen or antibody to be detected is realized.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials and electrochemical sensing, in particular to a graded zeolite imidazolate framework structure (ZIFs) / metal oxide / molybdenum sulfide composite material and its preparation method and application. Background technique [0002] With the rapid development of sensing technology, electrochemical biosensors have the advantages of high sensitivity, easy operation, and low cost compared with traditional large-scale detection equipment, and have broad application prospects in fields including medical diagnosis. The combination of two or more nanomaterials forms a three-dimensional composite material with a multi-level layered structure, which not only combines the advantages of each structural unit, but also gives the composite material new properties due to the synergistic enhancement effect between different components. Thus, the performance of the electrochemical biosensor is improved. [0003] T...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/30
CPCG01N27/3278G01N27/30
Inventor 张源温维佳应孜纪冬青高兴华梅提尼·简亚苏帕
Owner SHANGHAI UNIV