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Pharmaceutical composition for treating dermatophyte infection and preparation method thereof

A technology of dermatophytes and antifungal drugs, which is applied in the field of pharmaceutical compositions and preparations for treating skin fungal infections, and can solve problems such as difficulty in controlling tinea pedis, favorable fungal growth, and high incidence of tinea pedis

Inactive Publication Date: 2020-10-27
杨宇秀
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the rich sweat glands in the soles of the feet and between the toes, it is easy to cause local dampness, which is conducive to the growth of fungi, resulting in a high incidence of tinea pedis. problem

Method used

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  • Pharmaceutical composition for treating dermatophyte infection and preparation method thereof
  • Pharmaceutical composition for treating dermatophyte infection and preparation method thereof
  • Pharmaceutical composition for treating dermatophyte infection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Embodiment 1: This embodiment discloses a pharmaceutical composition for the treatment of skin fungal infections with good application effect and easy preparation, which includes the following components: azole antifungals, tincture of iodine, sodium chloride, menthol, camphor and auxiliary materials .

[0029] The azole antifungal drug is miconazole, and the auxiliary materials are solvent and moisturizing agent; the solvent is ethanol; and the moisturizing agent is a mixture of glycerin and propylene glycol.

[0030] Each component weight of this pharmaceutical composition is as follows:

[0031]

[0032] The preparation method of the pharmaceutical composition disclosed in this embodiment for the treatment of skin fungal infection is as follows:

[0033] Step 1: Stir iodine tincture, sodium chloride, menthol, camphor evenly; keep away from light, seal and store for later use;

[0034] Step 2: Add miconazole to propylene glycol, then add glycerin, and stir evenly...

Embodiment 2

[0036] Embodiment 2: This embodiment discloses a pharmaceutical composition for the treatment of skin fungal infections with good application effect and easy preparation, which includes the following components: azole antifungals, tincture of iodine, sodium chloride, menthol, camphor and auxiliary materials .

[0037] The azole antifungal drug is ketoconazole, the auxiliary material is a mixture of a penetration enhancer, a solvent and a moisturizing agent, the solvent is water, and the moisturizing agent is propylene glycol.

[0038] Each component weight of this pharmaceutical composition is as follows:

[0039] Element Dosage Ketoconazole 0.4g iodine tincture 10g Sodium chloride 1g Menthol 1g Camphor 1g Propylene Glycol 1.5g ethanol 4g

[0040] The preparation method of the pharmaceutical composition disclosed in this embodiment for the treatment of skin fungal infection is as follows:

[0041] Step 1: Stir iodine ...

Embodiment 3

[0045] Embodiment 3: This embodiment discloses a pharmaceutical composition for the treatment of skin fungal infections with good application effect and easy preparation, which includes the following components: azole antifungals, tincture of iodine, sodium chloride, menthol, camphor and auxiliary materials .

[0046] The azole antifungal drug is voriconazole; the auxiliary material is a mixture of a solvent, an aqueous base, an emulsifier, and a moisturizing agent, and the solvent is water; the aqueous base is carbomer; and the emulsifier is triethanolamine; The humectant is a mixture of glycerin and propylene glycol.

[0047] The weight of each component of this pharmaceutical composition is as follows:

[0048] Element Dosage Voriconazole 0.4g iodine tincture 10g Sodium chloride 1g Menthol 1g Camphor 1g carbomer 0.3g glycerin 1.5g Propylene Glycol 0.5g Triethanolamine 0.15g pure water 10g

[0049]...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating dermatophyte infection which is good in use effect and easy to prepare and a preparation method, and the pharmaceutical composition isprepared from the following components in parts by weight: 0.2-0.5 part of an antifungal drug, 0.5-1 part of sodium chloride, 9.5-12 parts of iodine tincture, 0.5-1 part of menthol and 0.5-1 part ofcamphor. The method comprises the following steps: 1, mixing iodine tincture, sodium chloride, menthol and camphor, uniformly stirring, keeping in a dark place, and sealing and storing for later use;2, mixing auxiliary materials and azole antifungal drugs, adding the solvent, and uniformly stirring; and 3, mixing the mixtures obtained in the step 1 and the step 2, and uniformly stirring. According to the pharmaceutical composition for treating dermatophyte infection and the preparation process thereof provided by the invention, various drugs with different antibacterial mechanisms are adoptedto synergistically treat dermatophytosis, so that the pharmaceutical composition has the advantages of wide treatment range, remarkable clinical curative effect, small toxic and side effects, convenience and safety in use, simple and feasible preparation process, low cost and small drug resistance, and is suitable for wide popularization and application.

Description

technical field [0001] The invention relates to the technical field of medical drugs, in particular to a pharmaceutical composition for treating skin fungus infection and a preparation method. Background technique [0002] Athlete's foot, also known as "tinea pedis", is a foot skin disease caused by pathogenic fungi. Due to the rich sweat glands in the soles of the feet and between the toes, it is easy to cause local dampness, which is conducive to the growth of fungi, resulting in a high incidence of tinea pedis. problem. [0003] Fungi are difficult to kill microorganisms and are prone to drug resistance. At present, there are mainly imidazole antibacterial drugs for fungal infections, such as ketoconazole, miconazole, terconazole, etc., and its mechanism is to inhibit the biosynthesis of the main sterol-ergosterol in the fungal cell membrane, damage the fungal cell membrane and change its Permeability, so that important intracellular materials leak out and die. At the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K33/18A61P31/10A61P17/00A61K33/14A61K31/045A61K31/125
CPCA61K45/06A61K33/14A61K33/18A61K31/045A61K31/125A61P31/10A61P17/00A61K2300/00
Inventor 杨宇秀
Owner 杨宇秀