Antibacterial absorbable medical soft tissue suture line and preparation method and application thereof

A suture and soft tissue technology, applied in the field of medical suture, can solve the problems of insufficient mechanical strength, unfavorable large-scale application, easy to lose water and difficult to place and store, achieve excellent adaptability, reduce secondary injuries, and avoid secondary damage. The effect of secondary damage

Active Publication Date: 2020-10-30
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, some wound dressings have also emerged for soft tissue repair, but there is no external support or suture material to fix the tissue, and wound dressings generally have the problem of insufficient mechanical strength
Moreover, most wound dressings are hydrogel materials, which are easy to lose water and difficult to store, which is not conducive to large-scale application.

Method used

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  • Antibacterial absorbable medical soft tissue suture line and preparation method and application thereof
  • Antibacterial absorbable medical soft tissue suture line and preparation method and application thereof
  • Antibacterial absorbable medical soft tissue suture line and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A preparation method of antibacterial absorbable suture, comprising the following steps:

[0053] (1) 2.5g chitosan (molecular weight 1000) is dissolved in 40ml dimethyl sulfoxide (DMSO), under nitrogen protection, add 1.5g p-aldehyde benzoic acid, 10mg 4-dimethylaminopyridine (DMAP), 5 mg of dicyclohexylcarbodiimide, reacted at room temperature 25°C for 24 hours, added water to precipitate, filtered, washed several times with water, dried and dialyzed with a dialysis bag with a molecular weight of 1000 for 3 days to obtain graft-modified aldehydated chitosan ;

[0054] (2) 0.6g carboxymethyl chitosan powder is dissolved in the deionized water of 10ml, 800rpm stirs 4h and dissolves completely and forms light yellow solution;

[0055] (3) Disperse 0.1 g of graft-modified aldehydated chitosan into 5 ml of deionized water, ultrasonically disperse it for 10 min, and slowly add it to the carboxymethyl chitosan solution, then Stir at 800rpm for 2h to a uniform solution to o...

Embodiment 2

[0059] A preparation method of antibacterial absorbable suture, comprising the following steps:

[0060] (1) 2.5g chitosan (molecular weight 1000) is dissolved in 40ml dimethyl sulfoxide (DMSO), under nitrogen protection, add 1.5g p-aldehyde benzoic acid, 10mg 4-dimethylaminopyridine (DMAP), 5 mg of dicyclohexylcarbodiimide, reacted at room temperature 25°C for 24 hours, added water to precipitate, filtered, washed several times with water, dried and dialyzed with a dialysis bag with a molecular weight of 1000 for 3 days to obtain graft-modified aldehydated chitosan ;

[0061] (2) Dissolve 0.4, 0.6, 0.8, 1.0, 1.2g of carboxymethyl chitosan powder in 10ml of deionized water respectively, and stir at 800rpm for 4h to completely dissolve to form a light yellow solution;

[0062] (3) Disperse 0.1 g of graft-modified aldehydated chitosan into 5 ml of deionized water, ultrasonically disperse it for 10 min, and slowly add it to the carboxymethyl chitosan solution, then Stir at 800r...

Embodiment 3

[0067] A preparation method of antibacterial absorbable suture, comprising the following steps:

[0068] (1) 2.5g chitosan (molecular weight 1000) is dissolved in 40ml dimethyl sulfoxide (DMF), and 1.5g p-aldehyde benzoic acid, 10mg 4-dimethylaminopyridine (DMAP) are added under nitrogen protection, 5 mg of dicyclohexylcarbodiimide, reacted at room temperature 25°C for 24 hours, added water to precipitate, filtered, washed several times with water, dried and dialyzed with a dialysis bag with a molecular weight of 1000 for 3 days to obtain graft-modified aldehydated chitosan ;

[0069] (2) 1.2g carboxymethyl chitosan powder is dissolved in the deionized water of 10ml, 800rpm stirs 4h and dissolves completely and forms light yellow solution;

[0070] (3) Disperse 0.2 g of graft-modified aldehylated chitosan into 5 ml of deionized water, ultrasonically disperse it for 10 min, and slowly add it to the carboxymethyl chitosan solution, then Stir at 800rpm for 2h to a uniform solut...

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Abstract

The invention discloses an antibacterial absorbable medical soft tissue suture line and a preparation method and application thereof. Carboxymethyl chitosan is adopted as a main carrier, carbon-supported copper and low-molecular-weight aldehyde chitosan are adopted as chelating agents, chitosan copper-based hydrogel is prepared, and then the antibacterial absorbable medical soft tissue suture linewith the diameter ranging from 0.01 mm to 3 mm is prepared through mechanical stretching or injection of an injector. The invention provides a method for preparing a soft tissue suture from super-stretching hydrogel for the first time. The suture line has good mechanical property, high biocompatibility and antibacterial property of a conventional suture line, also has excellent water absorption swelling property, and can reduce the occurrence of inflammatory reaction, the formation of scar tissues, tissue tearing and secondary injury to a patient caused by suture removal.

Description

technical field [0001] The invention belongs to the technical field of medical sutures, in particular to a bacteriostatic absorbable medical soft tissue suture and its preparation method and application. Background technique [0002] In recent years, more and more attention has been paid to the repair of soft tissue injuries such as liver, kidney, ovary, and lung. Traditional clinical treatments are dressings such as sutures or bioadhesives. According to the length of time for sutures to degrade in the body, they can be divided into absorbable sutures and non-absorbable sutures. Absorbable sutures are easy to degrade in the body, and the disadvantages are poor mechanical properties, easy to cause inflammation, and knots are easy to slip. The emergence of synthetic non-absorbable sutures has greatly improved the mechanical properties of sutures and solved the problem that suture knots are easy to fall off, but its rigid mechanical properties and weak tensile deformation abi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/06A61L17/10C08B37/08
CPCA61L17/06A61L17/10A61L2300/102A61L2300/232A61L2300/404C08B37/003C08L5/08
Inventor 蒋刚彪胡甜刘斌陈振翔李伟雄
Owner SOUTH CHINA AGRI UNIV
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