Unlock instant, AI-driven research and patent intelligence for your innovation.

Composition comprising benzoic acid amide compound and solubilizing agents

A technology of benzamide and composition, which is applied in the field of skin external preparation composition, to achieve the effect of improving solubility, excellent stability, and excellent solubility

Pending Publication Date: 2020-10-30
AMOREPACIFIC CORP
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there has been no study for improving the solubility of the composition containing the benzamide substance, and the researchers of the present invention have completed the present invention by studying a composition in which the solubility of the benzamide substance is improved.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition comprising benzoic acid amide compound and solubilizing agents
  • Composition comprising benzoic acid amide compound and solubilizing agents
  • Composition comprising benzoic acid amide compound and solubilizing agents

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to Embodiment 8

[0098] [Example 1 to Example 8] Increase the content of 5-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxy-benzamide (hereinafter, DBAB) Preparation of Solubilizers for Solubility

[0099] In order to confirm the solubilizer that increases the solubility of DBAB, 15% by weight of PEG / PPG-17 / 6 copolymer (Konlub) and 20% by weight of 1,3-propanediol (1,3-Propanediol) were added as the first solubilizer ( Fermandiol); as the second solubilizer, add 0.5% by weight of hydroxypropyl cyclodextrin (hereinafter referred to as CD, purchased from NIHON SHOKUHIN company); and as the third solubilizer, add 1% by weight of cellulose gum (Cellulose Gum; CMC), the remaining amount is filled with water, and is fully stirred at 3000rpm for 10 minutes to make it homogeneous by using an emulsifier (Primix Company, Japan, homomixer Mark2 model). Then, DBAB was added, and it stirred and mixed with an emulsifier for 20 minutes, and Example 1 was prepared.

Embodiment 2

[0101] Example 2: 1% by weight of hydroxypropyl methylcellulose (Hydroxypropyl methylcellulose; hereinafter referred to as HPMC) (Pharmacoat 630HPMC)

Embodiment 3

[0102] Embodiment 3: 0.5% by weight of sodium polyacrylate (Sodium Polyacrylate)

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present specification relates to an external-use skin preparation composition comprising: a solute which is a benzoic acid amide compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof; a first solubilizing agent which is one or more selected from the group consisting of a polyethylene glycol / polypropylene glycol copolymer, propylene glycol and polyethylene glycol-400; a second solubilizing agent which is a cyclodextrin; and a third solubilizing agent which is one or more selected from the group consisting of cellulose gum, xanthan gum, sodium polyacrylate, hydroxypropyl methyl cellulose, a hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer and polyacrylate-13 / polyisobutene / polysorbate-20, and provides an external-useskin preparation composition having improved solubility.

Description

technical field [0001] The present invention relates to a skin external preparation composition comprising: as a solute containing a benzamide compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof; and a solubilizer, and the The solubility of the composition is improved. Background technique [0002] Melanin blocks ultraviolet rays in the epidermis, protects the skin organs under the dermis, absorbs free radicals in organisms, and thus protects the skin. In addition, melanin is the main factor that determines the color of the skin, so if there is too much melanin, it will also cause skin pigmentation such as chloasma, freckles, and moles. Melanin is produced by melanocytes present in the basal layer of the skin, and it is known that production is promoted by stimulation such as ultraviolet rays or inflammation. Therefore, melanin production can be reduced by reducing external stimuli, preventing signal transmission...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/00A61K31/166A61P17/00A61K8/42A61Q19/02
CPCA61P17/00A61Q19/02A61K8/42A61K9/00A61K31/166
Inventor 李昌根朴城逸安知惠
Owner AMOREPACIFIC CORP