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Application of coptisine to preparation of medicine for treating ulcerative colitis

A technology for ulcerative colitis and coptisine, applied in the field of medicine, can solve the problems that there is no drug for ulcerative colitis of coptisine, and the anti-ulcerative colitis effect has not been reported, and achieve good therapeutic effect

Inactive Publication Date: 2020-11-03
遵义医科大学珠海校区
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Current studies only show that coptisine (COP) has various biological activities such as anti-oxidation, anti-inflammation, antibacterial, and regulation of lipid metabolism, but its role in anti-ulcerative colitis has not been reported, let alone the use of coptisine. A precedent in the preparation of drugs for the treatment of ulcerative colitis

Method used

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  • Application of coptisine to preparation of medicine for treating ulcerative colitis
  • Application of coptisine to preparation of medicine for treating ulcerative colitis
  • Application of coptisine to preparation of medicine for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A kind of coptisine medicament (tablet) for the treatment of ulcerative colitis, its preparation method comprises the following steps:

[0039] Take 50g of berberine, add 48g of lactose and 75.4g of starch, mix evenly, use 7% starch slurry 35g as a binder, wet granulate, dry, add 1.6g of magnesium stearate, mix evenly, and press it to make each tablet contain berberine 1000 tablets of alkali 50mg, each with a net weight of 0.21g.

[0040] Orally, for the treatment of ulcerative colitis. Symptoms: Abdominal pain, diarrhea, blood in the stool, weight loss, etc.

Embodiment 2

[0042] A coptisine medicament (capsule) for the treatment of ulcerative colitis, the preparation method of which comprises the following steps:

[0043] Take 50g of berberine, add 98g of lactose, 125.4g of starch and mix evenly, use 7% starch slurry 35g as a binder, wet granulate, dry, add 1.6g of magnesium stearate, mix evenly, fill to No. 1 capsule 1000 capsules, each capsule contains 50mg of coptisine, and the net weight of each capsule is 0.31g.

[0044] Orally, for the treatment of ulcerative colitis. Symptoms: Abdominal pain, diarrhea, blood in the stool, weight loss, etc.

Embodiment 3

[0046] A coptisine medicament (granule) for the treatment of ulcerative colitis, its preparation method may further comprise the steps:

[0047] Weigh 30g of berberine and add it to an appropriate amount of β-cyclodextrin to make an inclusion compound, add an appropriate amount of sucrose powder, microcrystalline cellulose, and starch slurry, mix evenly, gradually add ethanol and water to make granules, and carry out sub-packaging. The specifications are granules containing 50 mg of coptisine, and the net weight of each pack is 7 g.

[0048] Take it with boiled water and take it orally for the treatment of ulcerative colitis. Symptoms: Abdominal pain, diarrhea, blood in the stool, weight loss, etc.

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Abstract

The invention belongs to the field of medicines, and discloses an application of coptisine to preparation of a medicine for treating ulcerative colitis, and the structural formula of the coptisine isshown as a formula (I). The invention shows that the coptisine has a good treatment efficacy on ulcerative colitis, and provides a new application of the coptisine, namely, the coptisine is used for preparing the medicine for treating ulcerative colitis. The coptisine is a monomer component of a natural source in coptis chinensis and is not reported to have obvious side effects, so that the medicine for treating ulcerative colitis, prepared from the coptisine has the characteristics of low toxicity and high safety.

Description

technical field [0001] The invention belongs to the field of medicine, and particularly relates to the application of coptisine in the preparation of medicines for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) is a type of inflammatory bowel disease (Inflammatory Bowel Disease, IBD), which is a chronic non-specific disease of the rectum and colon with unknown etiology. The main clinical manifestations are diarrhea, abdominal pain, mucus pus and blood in the stool, and tenesmus. It has the characteristics of easy recurrence, difficult to cure, and easy canceration. It has been listed as one of the modern intractable diseases by the World Health Organization (WHO). Traditional Chinese medicine classifies UC into categories such as "intestinal addiction", "diarrhea", and "diarrhea", with damp-heat in the large intestine as its main pathogenesis. The disease is more common in western countries. In recent years, the incidence of UC in my coun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P1/00A61P1/04
CPCA61K31/4375A61P1/00A61P1/04
Inventor 李彩兰鲁强
Owner 遵义医科大学珠海校区
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