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Method and device for measuring temperature of biological tissue or cell

A technology of biological tissue and cells, applied in the field of temperature sensing, can solve the problems of poor controllability and achieve the effect of large scope and strong scalability

Active Publication Date: 2020-11-03
ZHEJIANG LAB +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In these studies, the temperature sensing units are randomly located in cells or between cells, and the controllability is poor.

Method used

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  • Method and device for measuring temperature of biological tissue or cell
  • Method and device for measuring temperature of biological tissue or cell
  • Method and device for measuring temperature of biological tissue or cell

Examples

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Embodiment 1

[0034] This embodiment takes the implementation of the present invention to realize temperature sensing at a specific position in a cell as an example. The first laser is a 1064nm single-mode laser, the objective lens 8 is a microscopic objective lens with a high numerical aperture NA=0.9, and diamond particles with a diameter of about 40nm containing NV color center defects are selected as the temperature sensitive unit.

[0035] image 3 It is the resonance spectrum of the electron spin in the ground state of the diamond NV color center defect and the change curve of the energy level corresponding to the resonance line with temperature, image 3 The figure on the left shows the resonance line of the ground state of the NV color center. This line has two peaks. The frequency corresponding to the median line D of the peak is related to temperature. The relationship curve is as follows image 3 As shown in the figure on the right, as the temperature increases, D decreases, and...

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Abstract

The invention discloses a method and device for measuring the temperature of a biological tissue or a cell, and the method comprises the steps: guiding diamond particles which contain spin defects andare in a micro-nano size into the biological tissue through a biochemical method, or guiding the diamond particles which contain the spin defects and are in the nano size into the cell through the biochemical method; detecting the energy level change of the diamond defect spinning ground state through microwave resonance or detecting the fluorescence spectrum change corresponding to the energy range of the defect excited state and the ground state to obtain the temperature of the pis detectedosition where the diamond particles are located, and regulating and controlling the positions of the diamond particles in biological tissue or cells precisely through optical tweezers. and thus, obtaining the temperatures of different positions in the biological tissue or cells By means of the methodand device, micro-nano-scale real-time dynamic temperature tracking detection can be conducted on target biological tissue or cells.

Description

technical field [0001] The invention relates to the field of temperature sensing, in particular to a method and device for measuring the temperature of biological tissues or cells. Background technique [0002] Temperature is a fundamental physical parameter regulated by the body, and while it is important, scientists know very little about how it varies within and between cells. The temperature difference between cells in the body is only a few degrees at most, but researchers now suspect that such small differences can change the chemical properties and function of cells, or help doctors shut down the growth of tumors. Temperature affects several processes in cells, from gene expression to protein-protein interactions. Use intracellular temperature to sort healthy and diseased cells, or to regulate cellular processes by altering cell temperature. Measuring small changes in temperature between different parts of the cell is therefore needed to reveal how heat is generated...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01K11/00
CPCG01K11/006
Inventor 李翠红陈杏藩傅振海高晓文蒋静胡慧珠
Owner ZHEJIANG LAB
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