IgY liposome spray and preparation method thereof

A liposome and lipid technology, applied in the directions of liposome delivery, antibodies, pharmaceutical formulations, etc., can solve the problems of destroying the immune system and resistance of patients, side effects of patients' health, and dependence of patients, so as to avoid inhibition. Effect, avoid enzyme damage, particle size reduction effect

Pending Publication Date: 2020-11-06
苏州瑞微生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Traditionally, antibiotics or hormone drugs are widely used in the treatment of skin inflammation and wound infection. Long-term use of these drugs will cause patients to become dependent, and hormones will destroy the patient's immune system and resistance, which has a great impact on the patient's health. side effects, and cannot fundamentally achieve the purpose of curing the disease

Method used

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  • IgY liposome spray and preparation method thereof

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Effect test

Embodiment 1

[0024] An IgY liposome spray comprises the following components in percentage by weight: 0.5% moisturizing agent, 0.5% preservative, 1% liposome lecithin, 0.5% stabilizer, 2% IgY antibody, and the rest is distilled water. Wherein, the humectant is trehalose, the preservative is 1,2 hexanediol, and the stabilizer is Tween 80.

[0025] The preparation process of liposomal lecithin is to dissolve egg yolk lecithin and cholesterol with hot ethanol to obtain a solution, wherein the concentration of egg yolk lecithin is 10 mg / mL, the concentration of cholesterol is 2 mg / mL, and the temperature of hot ethanol is 40 ° C. The solution was sheared and homogenized for 5 minutes, followed by high-pressure homogenization. The high-pressure homogenization pressure was 30 MPa, and the high-pressure homogenization time was 7 minutes to obtain liposomal lecithin. The average particle size was 88 nm, and the PDI was 0.25. ±0.09.

[0026] The preparation method of above-mentioned IgY liposome s...

Embodiment 2

[0033] An IgY liposome spray comprises the following components in weight percentage: 1% moisturizing agent, 1.5% preservative, 2% liposome lecithin, 0.8% stabilizer, 3% IgY antibody, and the rest is distilled water. Wherein, the moisturizing agent is trehalose, the preservative is hydroxyacetophenone, and the stabilizer is Tween 80.

[0034] The preparation process of liposomal lecithin is to dissolve egg yolk lecithin and cholesterol with hot ethanol to obtain a solution, wherein the concentration of egg yolk lecithin is 10 mg / mL, the concentration of cholesterol is 2 mg / mL, and the temperature of hot ethanol is 40 ° C. The solution was sheared and homogenized for 5 minutes, followed by high-pressure homogenization. The high-pressure homogenization pressure was 30 MPa, and the high-pressure homogenization time was 7 minutes to obtain liposomal lecithin. The average particle size was 90 nm, and the PDI was 0.21 ± 0.08.

[0035] The preparation method of above-mentioned IgY l...

Embodiment 3

[0042] An IgY liposome spray comprises the following components in percentage by weight: 1.5% moisturizing agent, 1% preservative, 2.5% liposome lecithin, 1% stabilizer, 4% IgY antibody, and the rest is distilled water. Wherein, the moisturizing agent is trehalose, the preservative is hydroxyacetophenone, and the stabilizer is Tween 80.

[0043] The preparation process of liposomal lecithin is to dissolve egg yolk lecithin and cholesterol with hot ethanol to obtain a solution, wherein the concentration of egg yolk lecithin is 10 mg / mL, the concentration of cholesterol is 2 mg / mL, and the temperature of hot ethanol is 40 ° C. The solution is sheared and homogenized, homogenized for 5min, then high-pressure homogenized, and the high-pressure homogenized pressure is 30MPa, and the high-pressure homogenized time is 7min, and the liposomal lecithin is obtained, and its particle diameter is that the average value is 90nm, and the PDI is 0.22±0.05.

[0044] The preparation method of...

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Abstract

The present invention discloses an IgY liposome spray and belongs to the technical field of biology. A main point of a technical solution is as follows: the IgY liposome spray comprises the followingcomponents in weight percentages: 0.5-2% of a humectant, 0.5-2% of a preservative, 1-3% of liposomal lecithin, 0.5-1% of a stabilizer, 2-5% of IgY antibodies and the balance distilled water. The prepared antibody spray can target inflamed parts, effectively neutralizes and eliminates over-expressed and secreted inflammatory factors in the skin tissues, achieves a purpose of fundamentally curing diseases, at the same time, can enable the antibodies to penetrate the skin to reach the site of action faster by using a liposome spraying mode, and thus achieves a more effective treatment effect.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an IgY liposome spray and a preparation method thereof. Background technique [0002] Antibodies are immunoglobulins produced by plasma cells differentiated from B cells under the stimulation of antigenic substances, and can specifically bind and react with antigens. As antibodies, immunoglobulins are divided into five categories, including IgY, IgA, IgM, IgD and IgE, and each has its own unique antigenicity. Antibodies are widely used in medical practice. For example, it has certain effects in the prevention, diagnosis and treatment of diseases. [0003] Traditionally, antibiotics or hormone drugs are widely used in the treatment of skin inflammation and wound infection. Long-term use of these drugs will cause patients to become dependent, and hormones will destroy the patient's immune system and resistance, which has a great impact on the patient's health. Side effects, and can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K9/12A61K9/127A61K47/24A61K47/26A61P29/00
CPCA61K39/395A61K9/12A61K9/127A61K9/0014A61K47/24A61K47/26A61P29/00
Inventor 王泽宇
Owner 苏州瑞微生物科技有限公司
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