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Microneedle patch with ultrathin flexible backing layer and preparation method thereof

A technology of backing layer and microneedle sticking, which is applied in the direction of microneedle, needle, sheet conveying, etc., can solve the problems of increasing the precision, difficulty and cost of microneedle preparation, complicated preparation method, and many material restrictions, and achieves the goal of drying. The effect of short time required, material cost advantages, and huge commercial value

Pending Publication Date: 2020-11-17
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation methods of the above-mentioned prior art are too complicated and difficult, and there are many restrictions on the materials. The multi-step preparation process of the microneedles will increase the preparation accuracy, difficulty and cost of the microneedles, and the material needs to be considered. Biosafety of chemical crosslinking

Method used

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  • Microneedle patch with ultrathin flexible backing layer and preparation method thereof
  • Microneedle patch with ultrathin flexible backing layer and preparation method thereof
  • Microneedle patch with ultrathin flexible backing layer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Microneedle preparation

[0035] 1. Preparation of microneedle matrix solution

[0036] Take the required amount of hyaluronic acid (10KDa) and dissolve it in ultrapure water to prepare a microneedle matrix solution with a concentration of 100% (100g / 100mL). The viscosity of the matrix solution is 44696cp.

[0037] 2. Pressurized perfusion

[0038] Take 12 μL of the above solution at a time and apply it on the microneedle mold, place the mold as a whole in a pressurized chamber, adjust the pressure to 0.6 MPa, and pressurize for 15 minutes.

[0039] 3. Curing and demoulding

[0040] The pressurized microneedle mold is placed in a desiccator, dried at room temperature for 1.5 hours, and peeled off to obtain the final product.

[0041] 2. Determination of the thickness of the patch backing layer

[0042] The patch thickness was measured to be 20 μm.

[0043] 3. Determination of patch dry weight

[0044] In order to more accurately determine the amount of hyaluron...

Embodiment 2

[0048] 1. Microneedle preparation

[0049] 1. Preparation of microneedle matrix solution

[0050] Dissolve the required amount of hyaluronic acid (10KDa) and rhodamine B in ultrapure water to prepare a microneedle matrix containing rhodamine B 0.2% (100g / 100mL) and sodium hyaluronate 100% (100g / 100mL) liquid, matrix liquid viscosity: 44696cp.

[0051] 2. Pressurized perfusion

[0052] Take 15 μL of the above solution at a time and apply it on the microneedle mold, place the mold as a whole in a pressurized chamber, adjust the pressure to 0.7 MPa, and pressurize for 20 minutes.

[0053] 3. Curing and demoulding

[0054] The pressurized microneedle mold is placed in a desiccator, dried at room temperature for 1.5 hours, and peeled off to obtain the final product.

[0055] 2. Determination of the thickness of the patch backing layer

[0056] The patch thickness was measured to be 25 μm.

[0057] 3. Determination of patch dry weight

[0058] In order to more accurately dete...

Embodiment 3

[0062] 1. Microneedle preparation

[0063] 1. Preparation of microneedle matrix solution

[0064] Take the required amount of hyaluronic acid (10KDa) and dissolve it in ultrapure water to prepare a microneedle matrix solution with a concentration of 100% (100g / 100mL). The viscosity of the matrix solution is 44696cp.

[0065] 2. Pressurized perfusion

[0066] Take 18 μL of the above solution at a time and apply it on the microneedle mold, place the mold as a whole in a pressurized chamber, adjust the pressure to 0.5 MPa, and pressurize for 15 minutes.

[0067] 3. Curing and demoulding

[0068] The pressurized microneedle mold is placed in a desiccator, dried at room temperature for 2 hours, and then peeled off.

[0069] 2. Determination of the thickness of the patch backing layer

[0070] The patch thickness was measured to be 30 μm.

[0071] 3. Determination of patch dry weight

[0072] In order to more accurately determine the amount of hyaluronic acid actually required...

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Abstract

The invention provides a microneedle patch with an ultrathin flexible backing layer and a preparation method thereof. The microneedle patch comprises a needle body and the backing layer, wherein the thickness of the backing layer is preferably 10-80 microns. The microneedle patch is simple in preparation process and low in cost, particularly, the material cost of the microneedle patch with the ultrathin backing layer is further reduced, the time required in the preparation process is shortened, and the microneedle patch is extremely suitable for industrial production of microneedles. The thinbacking layer has obvious flexibility and has better fitting performance when applied to the skin of uneven parts and joints of human bones and muscles, and the microneedle patch has great significance for application and expansion of microneedle administration.

Description

technical field [0001] The invention relates to the field of microneedle patch preparations for transdermal administration, in particular to a microneedle patch with an ultra-thin flexible backing layer and a preparation method thereof. Background technique [0002] The design concept of microneedles is to make needle-forming materials into micron-scale needles through micro-fabrication. When the needles penetrate the skin, they can form micropores of corresponding shapes and sizes on the stratum corneum without Touch the dermis and nerve tissue, so as to achieve the effect of painless drug delivery. Microneedle administration has many advantages, such as painless administration, and compared with ordinary needle injection, microneedle patients have better compliance; Under certain conditions, patients can self-administer medication without the need for professional medical and health personnel; due to the low water and low humidity environment of microneedles, it can impro...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61K9/70
CPCA61M37/0015A61K9/0021A61K9/7023A61M2037/0023A61M2037/0053
Inventor 孙逊何鹏辉张志荣龚涛
Owner SICHUAN UNIV
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