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A self-adhesive myocardial patch material and its preparation method

A self-adhesive, myocardial technology, applied in the field of biomedicine and biomaterials, can solve problems such as changes in immune response, secondary damage to the heart, and limited cell survival rate, and achieve the effect of increasing electrical activity and enhancing conduction

Active Publication Date: 2021-07-27
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, it has been clinically proven that stem cell implantation can improve the heart function of patients with myocardial infarction, but the biggest bottleneck of stem cell implantation treatment is the limited survival rate of cells after implantation, serious cell loss, and the immune response after cell implantation. may lead to pathological changes
[0004] Myocardial patch is used to repair myocardial cells in the infarcted area. If the patch needs additional help (such as manual fast suture fixation, tissue-specific fixing tape), it will undoubtedly cause secondary damage to the heart.

Method used

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  • A self-adhesive myocardial patch material and its preparation method
  • A self-adhesive myocardial patch material and its preparation method
  • A self-adhesive myocardial patch material and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0041] A self-adhesive myocardial patch material, its raw materials include the following components by weight:

[0042] 50 parts of acrylic acid, 0.125 parts of dopamine, 0.38 parts of pyrrole, 1 part of ammonium persulfate, 0.04 parts of N,N'-methylenebisacrylamide, 0.015 parts of ferric chloride;

[0043] The method for preparing the myocardial patch by using the above-mentioned raw materials is as follows: comprising the following steps:

[0044] (1) reacting the acrylic acid, ammonium persulfate, and N,N-methylenebisacrylamide in parts by weight at 60°C for 30 hours;

[0045] (2) react the dopamine, pyrrole and 0.01 part of ferric chloride of said parts by weight at room temperature for 3 hours; specifically: first dissolve pyrrole in the aqueous solution, and stir at room temperature for 30 minutes to obtain the pyrrole solution; then dissolve the dopamine Add it to the pyrrole solution in water, then add 0.01 part of ferric chloride, and stir at room temperature for 1 ho...

Embodiment 2

[0051] The raw material of this embodiment comprises the following components by weight:

[0052] 50 parts of acrylic acid, 0.1 part of dopamine, 0.1 part of pyrrole, 0.05 part of ammonium persulfate, 0.1 part of N,N'-methylenebisacrylamide, 0.05 part of ferric chloride;

[0053] Its preparation method is identical with embodiment 1;

[0054] The tensile strength and fracture energy of the prepared myocardial patch material are 60KPa, 10KJ / m 2 , the conductivity is 0.4S / m, and the adhesion is 2500Jm -2 .

Embodiment 3

[0056] The raw material of this embodiment comprises the following components by weight:

[0057] 50 parts of acrylic acid, 0.1 part of dopamine, 0.1 part of pyrrole, 0.5 part of ammonium persulfate, 0.01 part of N,N'-methylenebisacrylamide, 0.01 part of ferric chloride;

[0058] Its preparation method is identical with embodiment 1;

[0059] The tensile strength and fracture energy of the prepared myocardial patch material are 15KPa, 2KJ / m 2 , the conductivity is 0.2S / m, and the adhesion is 800J / m -2 .

[0060] Verification example 1:

[0061] Referring to the preparation method of Example 1, and other conditions remain unchanged, react acrylic acid, ammonium persulfate, and N,N-methylenebisacrylamide at 60°C for 30 hours, and then add 0, 0.01, 0.05, and 0.1 parts of The ferric chloride solution was stirred evenly and stood still to form a gel, and the mechanical properties of the gel were evaluated by a universal tensile testing machine. It is found by experiment that t...

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Abstract

The invention discloses a self-adhesive myocardial patch material, which belongs to the technical field of biomedicine and biomaterials, and its raw materials include the following components in parts by weight: 10-100 parts of acrylic acid, 0.1-5 parts of dopamine, and 0.1 parts of pyrrole -5 parts, 0.5-5 parts of ammonium persulfate, 0.01-0.1 parts of N,N'-methylenebisacrylamide, 0.01-0.1 parts of ferric chloride. It is prepared by pot method; the myocardial patch material of the present invention has the mechanical strength, electrical activity and excellent self-adhesive performance matched with the human heart.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and biomaterials, and in particular relates to a self-adhesive myocardial patch material and a preparation method thereof. Background technique [0002] In recent years, the number of patients with myocardial infarction has been increasing year by year in my country and even in the world. Although clinically there are thrombolytic drug interventions, interventional therapy, and even severe patients can take coronary artery bypass surgery to relieve the expansion of the infarct area; but cardiomyocytes are a kind of terminally differentiated cells, the above-mentioned methods are effective for necrotic myocardium Cells are not repairing. If a large area of ​​myocardial cell necrosis may cause arrhythmia, scar healing, heart failure and even sudden arrest. [0003] At present, it has been clinically proven that stem cell implantation can improve the heart function of patients with myocardial i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/02A61L27/16A61L27/18A61L27/50A61L27/52
CPCA61L27/025A61L27/16A61L27/18A61L27/50A61L27/52A61L2430/20C08L33/02C08L79/04C08L79/02
Inventor 邱逦陈钦赵长生赵伟锋李苒
Owner SICHUAN UNIV
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