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Thiodiglycol molecularly imprinted polymer as well as preparation method and application thereof

A technology of thiodiglycol and molecular imprinting, which is applied in the field of analysis and detection, can solve problems such as unsatisfactory peak shape and difficult on-site real-time detection of TDG, and achieve beneficial selectivity, good sensitivity, and improved detection efficiency.

Active Publication Date: 2020-11-20
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

TDG can also be analyzed by GC-MS, but the peak shape is not ideal. When the concentration of analysis is lower than 1ppm, derivatization is required, and TDG needs to be modified into derivatives with higher volatility and less polarity to pass GC-MS. MS for quantitative and qualitative analysis
These detection methods not only require expensive instruments and reagents, but also require professional personnel to operate, and it is difficult to realize on-site instant detection of TDG

Method used

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  • Thiodiglycol molecularly imprinted polymer as well as preparation method and application thereof
  • Thiodiglycol molecularly imprinted polymer as well as preparation method and application thereof
  • Thiodiglycol molecularly imprinted polymer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of thiodiglycol molecularly imprinted polymer

[0039] Add α-methacrylic acid to the thiodiglycol solution, sonicate for 10 minutes and mix well, then add N,N-dimethylmethylene bisacrylamide, sonicate for 30 minutes and mix well, then add ammonium persulfate, and ultrasonically treat at 35°C The intermediate product is obtained after 1 hour. The intermediate product is soaked in chloroform, after ultrasonic treatment for 10 minutes, placed on a shaker and shaken for 50 minutes. During the shaking, replace the previous hypochloroform with new chloroform for 2 times, and take the solid phase at 30°C Dry to constant weight to prepare thiodiglycol molecularly imprinted polymer, in which the molar mass ratio of α-methacrylic acid, thiodiglycol, N,N-dimethylmethylenebisacrylamide and ammonium persulfate It is 2:1:0.08:0.05, mol:mol:mg:mg.

[0040] The SEM image of the intermediate product in Example 1 is as follows figure 1 Shown by figure 1 It can be seen that the in...

Embodiment 2

[0042] Preparation of test paper for detecting mustard gas poisoning marker thiodiglycol

[0043] Add α-methacrylic acid to the thiodiglycol solution, sonicate for 10 minutes and mix well, then add N,N-dimethylmethylene bisacrylamide, sonicate for 30 minutes and mix well, then add ammonium persulfate, and add 5×10mm Soak the nitrocellulose membrane in it. After ultrasonic treatment at 35°C for 1 hour, take out the nitrocellulose membrane and soak in chloroform. After ultrasonic treatment for 10 minutes, place it on a shaker and shake for 50 minutes. During shaking, replace with new chloroform before Hypochloroform was replaced twice, the nitrocellulose membrane was taken out and dried to constant weight at 30°C to prepare a test paper for detecting mustard gas poisoning marker thiodiglycol. Among them, α-methacrylic acid, thiodiglycol, The molar mass ratio of N,N-dimethylmethylenebisacrylamide and ammonium persulfate is 2:1:0.08:0.05, mol:mol:mg:mg.

[0044] The SEM image of the n...

Embodiment 3

[0053] On the basis of Example 2, the molar ratio of thiodiglycol and α-methacrylic acid was set to 1:0, 1:2, 1:4, 1:6, and 1:8 to investigate the template molecule and function The effect of the molar ratio of monomers on the color development of the test strip, the results are as follows Image 6 Shown by Image 6 It can be seen that when the molar ratio of thiodiglycol and α-methacrylic acid is 1:2, the red value of the test paper is the strongest. This is because one molecule of thiodiglycol can form hydrogen bonds with two molecules of α-methacrylic acid. Therefore, when the molar ratio of the two is 1:2, the thiodiglycol molecularly imprinted polymer that specifically recognizes thiodiglycol can be prepared, so that the final prepared test paper has the best thiodiglycol sensing performance.

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Abstract

The invention relates to a thiodiglycol molecularly imprinted polymer as well as a preparation method and application thereof, and belongs to the technical field of analysis and detection. The preparation method comprises the following steps: taking thiodiglycol as a template molecule, combining the template molecule thiodiglycol with a functional monomer alpha-methacrylic acid through a hydrogenbond, adding a cross-linking agent N,N-dimethyl methylene bisacrylamide and an initiator ammonium persulfate, performing a polymerization reaction, finally washing off the template molecule, and leaving a binding site capable of specifically identifying thiodiglycol, thereby obtaining the thiodiglycol molecularly imprinted polymer. After the polymer specifically adsorbs thiodiglycol; thiodiglycolhas sulfur atoms; a firm gold-sulfur bond can be formed with the gold nano particles; the polymer can adsorb a large amount of gold nano particles to form macroscopic red, such that the polymer can achieve the visual detection of thiodiglycol, and the polymer is loaded on a nitrocellulose membrane to prepare test paper so as to achieve on-site real-time detection of a mustard gas poisoning markerthiodiglycol. The polymer and the corresponding test paper are simple in preparation method, easy to operate and suitable for expanded production.

Description

Technical field [0001] The invention belongs to the technical field of analysis and detection, and specifically relates to a thiodiglycol molecularly imprinted polymer and a preparation method and application thereof. Background technique [0002] Mustard gas is a chemical warfare agent widely used in the military. Because of the high toxicity of mustard gas can make opponents lose combat effectiveness, it is called the "king of war" and "the preferred chemical weapon in modern tactical warfare." Based on intramolecular cyclization, mustard gas molecules spontaneously form highly reactive and unstable intermediates and produce toxicity. Mustard gas is a strong alkylating agent, which can react quickly with various free nucleophilic sites in biological media, and has mutagenic, carcinogenic and cytotoxic effects. Mustard gas not only causes direct damage to the skin, eyes and lungs, but also chromosomal damage, especially for people who may be exposed to mustard gas for a long ti...

Claims

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Application Information

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IPC IPC(8): C08F220/06C08F222/38C08J9/26B01J20/26B01J20/30G01N21/78C08L33/02
CPCC08F220/06C08J9/26B01J20/268G01N21/78C08J2333/02C08J2201/0424C08F222/385
Inventor 甄淑君叶启超詹蕾
Owner SOUTHWEST UNIVERSITY
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