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Preparation of gold nanoparticles based on D-arabinose reduction

A gold nanoparticle, arabinose technology, applied in nanotechnology and other directions, can solve the problems of high cytotoxicity and low degree of environmental protection

Inactive Publication Date: 2020-11-24
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In view of the shortcomings of the existing traditional chemical reduction method to prepare AuNPs, such as: low degree of environmental protection, high cytotoxicity, etc., it is proposed to use D-arabinose as a reducing agent and modifier to prepare new gold nanoparticles. This method has a simple preparation process and does not need to use Organic solvent, the prepared AuNPs have good dispersion and uniform size

Method used

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  • Preparation of gold nanoparticles based on D-arabinose reduction
  • Preparation of gold nanoparticles based on D-arabinose reduction
  • Preparation of gold nanoparticles based on D-arabinose reduction

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Embodiment 1

[0021] The preparation method of D-arabinose modified gold nanoparticles of the present invention is characterized in that it comprises the following steps:

[0022] a. Add 2.0mL, 0.5mol / L D-arabinose solution to 16.00ml, 4.0×10 -4 mol / L chloroauric acid solution to obtain a mixed solution.

[0023] b. Heat the (1) solution in a water bath at 50° C. and 500 rpm magnetic stirring for 5 minutes.

[0024] c. Then pipette 40.0 μL, and quickly add 1.0 mol / L sodium hydroxide solution into the mixed solution, and stir for 30 seconds to obtain wine red D-arabinose-modified gold nanoparticles. Cool to room temperature and store in a 4°C refrigerator away from light.

Embodiment 2

[0026] The preparation method of D-arabinose modified gold nanoparticles of the present invention is characterized in that it comprises the following steps:

[0027] a. Add 2.0mL, 0.75mol / L D-arabinose solution to 18.00ml, 4.0×10 -4 mol / L chloroauric acid solution to obtain a mixed solution.

[0028] b. Heat the solution of a at 60°C in a water bath with 500 rpm magnetic stirring for 5 minutes.

[0029] c. Then pipette 40.0 μL, and quickly add 1.0 mol / L sodium hydroxide solution into the mixed solution, and stir for 30 seconds to obtain wine red D-arabinose-modified gold nanoparticles. Cool to room temperature and store in a 4°C refrigerator away from light.

Embodiment 3

[0031] The preparation method of D-arabinose modified gold nanoparticles of the present invention is characterized in that it comprises the following steps:

[0032] a. Add 2.0mL, 1.0mol / L D-arabinose solution to 20.00ml, 4.0×10 -4 mol / L chloroauric acid solution to obtain a mixed solution.

[0033] b. Heat the solution of a at 60°C in a water bath with 500 rpm magnetic stirring for 5 minutes.

[0034] c. Then pipette 40.0 μL, and quickly add 1.0 mol / L sodium hydroxide solution into the mixed solution, and stir for 30 seconds to obtain wine red D-arabinose-modified gold nanoparticles. Cool to room temperature and store in a 4°C refrigerator away from light.

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Abstract

The invention belongs to the technical field of nano metal materials and relates to a method of prepaaring gold nanoparticles based on D-arabinose reduction. The method is simple in preparation flow,free of organic solvents and environmental-friendly. The prepared nanoparticles can be uniformly dispersed in an aqueous solution without being aggregated. The nanoparticles are nanoscale and the diameters of the nanoparticles can be adjusted by changing a preparation condition. The gold nanoparticles modified by D-arabinose can be applied to visual chiral recognition and detection as a result ofa special local surface plasma resonance effect of the gold nanoparticles. In addition, the gold nanoparticles modified by D-arabinose have excellent biocompatibility and can be applied to the biological field.

Description

technical field [0001] The invention relates to the technical field of nano-metal materials. Based on D-arabinose as a reducing agent and a stabilizer, D-arabinose-stabilized gold nanoparticles are prepared. The preparation conditions are simple, environment-friendly and have broad application prospects. Background technique [0002] In recent years, noble metal nanoparticles have broad application prospects in the fields of physics, chemistry, biology, materials science and medicine due to their unique thermal, electronic, optical, electrical and magnetic properties. Among them, gold nanoparticles (AuNPs) are widely used in sensors, photonic circuits and in medical diagnosis and treatment. [0003] The synthesis of AuNPs often relies on chemical reduction methods, usually using highly reactive reducing agents such as sodium borohydride (NaBH 4 ), sodium citrate, hydrazine (N 2 h 4 ) and formaldehyde, and even cytotoxic surfactants such as cetyltrimethylammonium bromide ...

Claims

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Application Information

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IPC IPC(8): B22F9/24B82Y40/00
CPCB22F9/24B82Y40/00
Inventor 何华胡凡刘东昊宋兆瑞
Owner CHINA PHARM UNIV
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