Colloidal gold immunochromatography detection card for combined detection of COVID-19N antigen and S protein antibody
A technology of COVID-19N and immunochromatography, applied in the field of test cards for joint detection of viral antigens and antibodies, to achieve the effects of improving the detection rate, preventing the spread of the epidemic, and being easy to operate
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Embodiment 1
[0043] A colloidal gold immunochromatographic test card for joint detection of novel coronavirus COVID-19N antigen and S protein antibody, the test card consists of a card case, two sample holes arranged on the card case and a test paper containing COVID-19N antigen strip or the two observation windows of the COVID-19S protein antibody test strip, wherein:
[0044] The sampling holes on the cartridge and the observation window are arranged in a straight line at intervals, and each group of sampling holes and the observation window are arranged in the same direction and arranged in parallel at intervals; the COVID-19N antigen detection test strips are sequentially connected by the first product pad, the first binding pad, the first reaction pad and the first water-absorbing pad; wherein the first binding pad is sprayed with colloidal gold-labeled novel coronavirus COVID-19N protein monoclonal antibody, and the upper edge of the first reaction pad is The direction of sample flow...
Embodiment 2
[0060] The colloidal gold immunochromatography detection card for the joint detection of novel coronavirus COVID-19N antigen and S protein antibody according to the present invention is used as a test device for determining the presence or absence of novel coronavirus COVID-19, wherein the method of using the detection card is :
[0061] Drop the tested sample solution onto the sample pads of the COVID-19N antigen detection test strip and the COVID-19S protein antibody detection test strip respectively, wherein the tested sample is a human serum, plasma or whole blood sample; After 20 minutes, judge whether the sample contains novel coronavirus COVID-19N antigen and S protein antibody according to the color development of the detection line and the quality control line. The judgment method is as follows:
[0062] For the COVID-19N antigen detection test strip, 1) positive: the first quality control line and the first detection line both show red bands, indicating that the samp...
Embodiment 3
[0066] Colloidal gold immunochromatography detection card performance evaluation of joint detection novel coronavirus COVID-19N antigen and S protein antibody according to the present invention.
[0067] Clinical sample detection: The number of clinical samples carried out in the experiment is 200 cases, including 23 confirmed cases. The nucleic acid test results of these 13 confirmed cases are positive. The colloid of the new coronavirus COVID-19N antigen and S protein antibody of the present invention The test result of the gold immunochromatography test card is also positive, and the consistency rate reaches 100%. Wherein 1 case is that its nucleic acid and antigen are negative in discharge check-up, but S protein IgG is still positive. It proves that the colloidal gold immunochromatographic detection card for joint detection of novel coronavirus COVID-19N antigen and S protein antibody described in the present invention can be used as a test device for determining the pres...
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