Preparation method of 6-deuterated dansyl chloride

A technology of dansyl chloride and deuteration, which is applied in the field of preparation of 6-deuterated dansyl chloride, can solve the problems of low yield and achieve the effects of less intermediate products, improved yield, high yield and high quality
CN112010790AInactive Publication Date: 2020-12-01INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Publication Date
2020-12-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of isotope derivatization reagent preparation, and particularly relates to a preparation method of 6-deuterated dansyl chloride. According to the preparation method, 6-deuterated dansyl chloride can be prepared from reaction raw materials including 5-amino-1-naphthalene sulfonic acid, sodium hydride, deuterated methyl iodide, phosphorus oxychloride andphosphorus pentachloride. The preparation method has the advantages of easily available raw materials, low toxicity, few intermediate products and high yield.
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Description

technical field

[0001] The invention belongs to the technical field of isotope derivatization reagents, in particular to a preparation method of 6-deuterated dansyl chloride. Background technique

[0002] In the study of metabolomics, small molecular compounds contained in biological samples can reflect the metabolic state of the body, and dansyl chloride can specifically bind to the active hydrogen atoms of small molecular compounds, thereby enhancing the mass spectrometric response of small molecular compounds. The combination of isotopic dansyl chloride derivatization reagents and dansyl chloride derivatization reagents has outstanding advantages in qualitative identification of metabolites and screening of unknown metabolites; the combination of deuterated dansyl chloride derivatization reagents with standard substances can be more convenient The obtained derivatized standard substance isotope standard is used to supplement co-elution and matrix effects in quantitative r...

Claims

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