Phosphoramidate derivatives of nucleoside compounds and uses of derivatives

A compound and alkyl technology, applied in the field of compounds and pharmaceutical compositions for the prevention or treatment of viral infections, enteroviridae viral infections, to achieve good metabolic stability, less toxic and side effects, and good bioavailability
CN112010916AActive Publication Date: 2020-12-01SUNSHINE LAKE PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUNSHINE LAKE PHARM CO LTD
Publication Date
2020-12-01

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Abstract

The invention belongs to the technical field of medicines, and relates to phosphoramidate derivatives of nucleoside compounds, uses of the phosphoramidate derivatives, and a pharmaceutical compositioncontaining the compounds. The derivatives and pharmaceutical composition can be used as an antiviral reagent, especially an anti-novel coronavirus (SARS-CoV-2) reagent. The invention also relates toa method for preparing the compounds and the pharmaceutical composition, and the use of the derivatives and pharmaceutical composition to prevention or treatment of viral infections, including but notlimited to, Flaviviridae viral infections, Filoviridae viral infections, Enteroviridae viral infections, Orthomyxoviridae viral infections, Paramyxoviridae viral infections, coronaviridae viral infections, particularly novel coronaviridae (SARS-CoV-2) infections.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical technology, and relates to compounds and pharmaceutical compositions for preventing or treating viral infections, and methods and uses thereof. Specifically, the present invention relates to phosphoramidate derivatives of nucleoside compounds and pharmaceutical compositions thereof, methods for preparing such compounds and pharmaceutical compositions, and their use in the prevention or treatment of viral infections, including but not limited to, yellow Viridae virus infection, Filoviridae virus infection, Enteroviridae virus infection, Orthomyxoviridae virus infection, Paramyxoviridae virus infection, Coronaviridae virus infection. In particular, the compounds of the present invention and their pharmaceutical compositions are used to prevent or treat novel coronavirus (SARS-CoV-2) infection. Background technique

[0002] The virological classification of coronavirus (Coronavirus, CoV) belongs to the...

Claims

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