Drying method of schisandra fruit alcohol extract and preparation method of compound liver-benepitino remedy capsule

A drying method, the technology of pentarenol, which is applied in the direction of drying solid materials, drying gas arrangement, heating to dry solid materials, etc., can solve the problems of long time consumption, difficult crushing, sticky materials, etc., to reduce labor intensity and easy crushing , the effect of improving production efficiency

Pending Publication Date: 2020-12-04
HINYE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, using the vacuum drying oven method described in the Chinese invention patent with the publication number CN106123496 to dry the Wuren alcohol extract not only takes a long time (up to 24 to 72 hours), but also the material becomes flaky after drying. Sticky, agglomerated, extremely difficult to crush, very unfavorable for mass production in workshops
In the Chinese invention patent with the publication number CN109556352, microwave vacuum drying is used to dry important liquid extracts, but this method is only suitable for the use of traditional Chinese medicine liquid extracts with a density of 1.15 to 1.22, and the density of Wurenol thick paste is 1.25~1.35, this method cannot be used

Method used

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  • Drying method of schisandra fruit alcohol extract and preparation method of compound liver-benepitino remedy capsule
  • Drying method of schisandra fruit alcohol extract and preparation method of compound liver-benepitino remedy capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 7 kg of Schisandra chinensis was soaked in 30% ethanol for 24 hours, filtered, the filtrate was discarded, the dregs were dried, crushed into a coarse powder, and 75% ethanol was added to heat and reflux to extract three times, the first time was 3 hours, the second time was 2 hours, the third time For 1 hour, combine the extracts, let stand for 48 hours, take the supernatant, recover ethanol to a thick paste with a relative density of 1.25-1.35 (50°C), add an appropriate amount of 90% ethanol, heat and reflux for 2 hours, filter, and the filtrate is static Leave it for 24 hours, take the supernatant and recover ethanol to a thick paste of Wuren with a relative density of 1.25-1.35 (50°C).

Embodiment 2

[0032] Example 2 drying pre-treatment condition optimization

[0033] In the high-speed mixing granulator and in the trough mixer, the materials under different mixing ratios were mixed, and the effect was compared:

[0034] Take the thick paste of Wuren in Example 1, add cornstarch respectively according to the thick paste of Wuren: corn starch = 1:1.25, 1:1.5, 1:1.75, 1:2.0 or 1:2.25 (mass ratio), respectively Blend in a high-speed mixer granulator. The parameter settings of the high-speed mixing granulator include: stirring speed: 160 rpm; shearing speed: 1440 rpm; order and method of adding materials: add auxiliary materials first, and when the equipment is turned on (stirring speed: 160 rpm / min; shear speed: 1440 rev / min) slowly add Wuren alcohol extract, control the addition in about 1min, start timing since adding corn starch, and control the total operation of the equipment to discharge more than 2min. Record the mixing and granulation of materials;

[0035] In add...

Embodiment 3

[0040] Embodiment 3 drying condition optimization

[0041] The mixed materials are dried by fluidized bed and vacuum box respectively, the temperature is set at 50-60°C, and dried until the water content is lower than 5.0%. The drying effect is compared:

[0042] Group 1: Take the granular material obtained by the high-speed mixing granulator (thick paste, starch ratio 1:2.0) in Example 2, and dry it in a fluidized bed at a temperature of 50-60°C until the water content is lower than 5.0%, and record Drying time and drying effect;

[0043] Group 2: Take another granular material obtained from the high-speed mixing granulator (thick paste, starch ratio 1:2.0) in Example 2, and dry it in a vacuum box at a temperature of 50-60°C until the moisture content is lower than 5.0%. Record the drying time and drying effect;

[0044] Group 3: Take the material obtained in Example 2 using a trough mixer (thick paste, starch ratio 1:0.5) (this material is in the form of a thick paste, not...

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Abstract

The invention relates to the technical field of pharmacy, and in particular to a drying method of a schisandra fruit alcohol extract. The drying method comprises the following steps: mixing the schisandra fruit alcohol extract with auxiliary materials, mixing in a high-speed mixing granulator, and drying in a fluidized bed to obtain schisandra fruit alcohol extract dry powder. According to the method, under specific set parameters, the extract can be well dried within a short time (20-40 minutes), and the obtained schisandra fruit alcohol extract dry powder is in a dispersed particle shape, has a moisture content of 2.7%-4.8% and is easy to crush.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a drying method of Wurenchun extract and a preparation method of compound Yiganling. Background technique [0002] Compound Yiganling Capsule has the effects of nourishing the liver, nourishing the kidney, detoxifying and removing dampness. It is used for hypochondriac pain caused by deficiency of liver and kidney yin and unclear damp toxin. Symptoms include hypochondriac pain, anorexia, abdominal distension, backache and weakness, yellow urine; chronic hepatitis sees the above syndromes. [0003] Compound Yiganling Capsules is a variety included in the 2015 edition of the Chinese Pharmacopoeia. The standard preparation method of the Chinese Pharmacopoeia is to prescribe 30g of silymarin, 700g of schisandra, the above two flavors, schisandra plus 30% ethanol to soak for 24 hours, filter, discard the filtrate, and dry the dregs. , crushed into a coarse powder, added 75% ethanol ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/57A61K9/14A61K9/06A61K9/48A61K47/36A61P1/16F26B3/084F26B5/04F26B21/00F26B21/10F26B25/22A61K31/357
CPCA61K36/79A61K36/57A61K31/357A61K9/146A61K9/06A61K47/36A61K9/4866A61P1/16F26B3/084F26B5/04F26B21/001F26B21/10F26B25/22A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 陈伟熊月姣彭伟张飘艳陈俊
Owner HINYE PHARM CO LTD
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