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A production process of pharmaceutical grade polyacrylic resin series products with zero waste water discharge and recyclable solvent

The technology of polyacrylic resin and series products is applied in the field of production technology of pharmaceutical grade polyacrylic resin series products, which can solve the problems of failing to meet the requirements of pharmacopoeia standards, large residues of pharmaceutical agents, increasing the pressure of waste water treatment, etc., and achieve a simple production process. Efficient, convenient for recycling, less residual effect

Active Publication Date: 2022-03-22
HUZHOU ZHANWANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] First, the water immersion crystallization molding method needs to be immersed in a large amount of water to harden the product, so a large amount of waste water containing organic solvents, monomers and benzoic acid will be generated, a large amount of material resources will be wasted, and the pressure on waste water treatment will be increased.
[0004] Second, some monomers remain in the product itself, which cannot meet the requirements of the Pharmacopoeia standard
[0007] However, the preparation method in this invention patent has the problem of large drug residues and potential safety hazards

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A production process of pharmaceutical-grade polyacrylic acid resin series products with zero discharge of waste water and recyclable solvent, comprising the following steps in sequence:

[0048] S1. Head tank ingredients, wherein by weight, the materials include 85kg of methacrylic acid, 85kg of methyl methacrylate, 250kg of 95% ethanol, 150kg of purified water and 3kg of benzoyl peroxide. Put all the above materials into the reaction kettle , heating and stirring to react to obtain the reaction material, wherein the temperature of the heating and stirring reaction is 70°C, and the time is 3.0h. The reaction material is put into the collection tank, and the upper roller rotates to adhere to the reaction material. The product, the evaporated solvent is recovered through the exhaust condenser group, in which the collecting tank is heated to the temperature of the reaction material at 45°C and kept there, the roller is heated to the surface temperature of 120°C, the rotati...

Embodiment 2

[0052] A production process of pharmaceutical-grade polyacrylic acid resin series products with zero discharge of waste water and recyclable solvent, comprising the following steps in sequence:

[0053] S1. Head tank ingredients, wherein by weight, the materials include 90kg of methacrylic acid, 95kg of methyl methacrylate, 280kg of 95% ethanol, 160kg of purified water and 4kg of benzoyl peroxide. Put all the above materials into the reaction kettle , heating and stirring to react to obtain the reaction material, wherein the temperature of the heating and stirring reaction is 75°C, and the time is 4.0h. The reaction material is put into the collection tank, and the upper roller rotates to adhere to the reaction material. The product, the evaporated solvent is recovered through the exhaust condenser group, in which the collecting tank is heated to the temperature of the reaction material at 49°C and kept, the drum is heated to the surface temperature of 140°C, and the rotation s...

Embodiment 3

[0057] A production process of pharmaceutical-grade polyacrylic acid resin series products with zero discharge of waste water and recyclable solvent, comprising the following steps in sequence:

[0058] S1. Head tank ingredients, wherein by weight, the materials include methacrylic acid 95kg, methyl methacrylate 98kg, 95% ethanol 320kg, purified water 190kg and benzoyl peroxide 4.5kg, put all the above materials into the reaction kettle During the heating and stirring reaction, the reaction material is obtained. The temperature of the heating and stirring reaction is 78 ° C, and the time is 4.5 hours. The product is dried, and the evaporated solvent is recovered through the exhaust condenser group. The collecting tank is heated to the temperature of the reaction material at 50°C and kept there. The drum is heated to the surface temperature of 160°C. The depth of immersion in the middle is 1 / 2 of its radius, wherein, the material of the annular surface of the adhesive reaction ...

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Abstract

The invention belongs to the technical field of synthesis of pharmaceutical excipients, and in particular relates to a production process for a series of pharmaceutical-grade polyacrylic acid resin products with zero discharge of waste water and recyclable solvents. The present invention achieves the effect of high-efficiency production of polyacrylic acid resin through the methods of batching in the head tank, heating and stirring reaction, heating and drying after roller adhesion, and finally crushing and screening. The invention has the method of heating and drying the reaction material after the roller is adhered, which saves a large amount of soaking water for crystallization and forming, does not generate waste water, has less monomer residue on the surface of the polyacrylic resin, facilitates recycling and reuse of solvents, and has a simple and efficient overall production process. advantage.

Description

technical field [0001] The invention belongs to the technical field of synthesis of pharmaceutical excipients, and in particular relates to a production process of a series of pharmaceutical-grade polyacrylic acid resin products with zero waste water discharge and recyclable solvents. Background technique [0002] Pharmaceutical-grade polyacrylic acid resin series products are generally used to make coating materials, film-forming materials and adhesives for pharmaceutical preparations. The existing technology of this polyacrylic resin product is: after the polymerization reaction of these two monomers of methacrylic acid and methyl methacrylate, the final product is obtained by soaking crystallization in water, but this existing technology also exists The following questions: [0003] First, the water immersion crystallization molding method needs to be immersed in a large amount of water to harden the product, so a large amount of wastewater containing organic solvents, m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/06C08F220/14C08F2/00C08F2/01
CPCC08F220/06C08F220/14C08F2/00
Inventor 潘继成
Owner HUZHOU ZHANWANG PHARMA