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Preparation method of luminescent Eu-based organic framework material for antibiotic recognition

A metal-organic framework, fluorescence recognition technology, applied in luminescent materials, material analysis by optical means, analysis of materials, etc., can solve the problems of skeleton collapse, metal ion detachment, etc., and achieve mild synthesis conditions, simple reaction conditions, and easy reactions. control effect

Active Publication Date: 2022-02-01
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It has been reported that some luminescent MOFs sensors have been used to detect antibiotics, but luminescent MOFs sensors capable of detecting two types of antibiotics are rarely reported.
In addition, many luminescent MOFs are unstable in water, and the collapse of the framework or the detachment of metal ions will occur, so analytes can only be detected in non-aqueous solvents (such as DMF, acetonitrile). is very valuable

Method used

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  • Preparation method of luminescent Eu-based organic framework material for antibiotic recognition
  • Preparation method of luminescent Eu-based organic framework material for antibiotic recognition
  • Preparation method of luminescent Eu-based organic framework material for antibiotic recognition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Take 0.04mmol of 5-(4-carboxyphenyl)picolinic acid, 0.04mmol of europium nitrate, 6mL of deionized water, and 3mL of ethanol, add them to a stainless steel reaction kettle with a polytetrafluoroethylene liner, and add 0.1mM sodium hydroxide dropwise solution, adjust the pH value of the reaction system to 9.0, and conduct a constant temperature solvothermal reaction at 160°C for 72 hours to obtain a white floc.

Embodiment 2

[0045] Take 0.04mmol of 5-(4-carboxyphenyl)picolinic acid, 0.04mmol of europium nitrate, 4mL of deionized water, and 3mL of ethanol, add them to a stainless steel reaction kettle with a polytetrafluoroethylene liner, and add 0.1mM sodium hydroxide dropwise solution, adjust the pH value of the reaction system to 9.0, and conduct a solvothermal reaction at a constant temperature of 160°C for 72 hours to obtain a small amount of colorless octahedral crystals and a large amount of white floc. The colorless octahedral crystals are 5-(4-carboxyphenyl ) picolinic acid Eu-based metal organic framework material.

Embodiment 3

[0047] Take 0.04mmol of 5-(4-carboxyphenyl)picolinic acid, 0.04mmol of europium nitrate, 3mL of deionized water, and 6mL of ethanol, add them to a stainless steel reaction kettle with a polytetrafluoroethylene liner, and add 0.1mM sodium hydroxide dropwise solution, adjust the pH value of the reaction system to 9.0, and conduct a constant temperature solvothermal reaction at 160°C for 72 hours to obtain a white floc.

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Abstract

The invention discloses a preparation method of a luminescent Eu-based organic framework material for antibiotic recognition. Its general chemical formula is: [Eu(cppa)(OH)]n, cppa represents the ligand 5‑(4‑carboxyphenyl) picolinic acid. Each Eu in crystalline material 3+ The ions are matched to four carboxyl oxygen atoms and one nitrogen atom and one hydroxyl oxygen atom in four different ligands, with four adjacent Eu atoms linked in pairs. Each tetranuclear secondary building block is bridged by growing carboxylic acid groups into 1D rod-shaped Eu 3+ carboxylic acid chain, each ligand adopts kappa 5 - N , O 1: O 2': O 4: O5 ’- mu 4 Bridge mode connection Eu 3+ ions, thus forming a three-dimensional porous framework. The coordination polymer has a fluorescent recognition effect on ornidazole and nitrofurantoin by adjusting the excitation wavelength, and can be detected in trace amounts. It has novel structure, simple synthesis and high detection efficiency, and is suitable for industrial production.

Description

technical field [0001] The present invention specifically designs a metal-organic framework material formed with 5-(4-carboxyphenyl)picolinic acid as an organic ligand and rare earth europium as a metal center, and at room temperature by modulating the excitation wavelength to detect the Fluorescence intensities in aqueous systems containing different antibiotics were used to quickly identify ornidazole and nitrofurantoin. Background technique [0002] Overuse of antibiotics can lead to resistance and failure of pathogens. At the same time, antibiotics are difficult to biodegrade and accumulate in the environment, causing great damage to the micro-ecological environment. Detecting them in the environment is therefore very important to protect the environment and human health. Among various detection technologies, analysis-response spectroscopy-based luminescence sensing technology has broad application prospects due to its high sensitivity and non-destructive characteristi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00C09K11/06G01N21/64
CPCC08G83/008C09K11/06G01N21/6428C09K2211/182G01N2021/6432
Inventor 李东升李博王延江孙亚亚刘闪吴亚盘张其春兰亚乾
Owner CHINA THREE GORGES UNIV