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A kind of spinosad tablet and its preparation method and application

A spinosad tablet, spinosad technology, applied in the directions of botanical equipment and methods, application, pesticides, etc., can solve the problems of insect control, inapplicability, difficult mosquito and long-term control, etc., to reduce the environment. The effect of reducing the cost of prevention and control, and improving the efficiency of prevention and control

Active Publication Date: 2021-06-29
BEIJING MULTIGRASS FORMULATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these dosage forms are mostly used for spraying plants, and cannot be used for controlling insects in water.
When spinosad is used in water environment, spinosad has the problems of easy photolysis, poor stability, short half-life (photolysis half-life in water is less than 1 day), and poor water solubility, making it difficult to apply Long-term control of mosquitoes in water; moreover, it is difficult to quickly and effectively release and diffuse in water, which also limits the efficacy of spinosad

Method used

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  • A kind of spinosad tablet and its preparation method and application
  • A kind of spinosad tablet and its preparation method and application
  • A kind of spinosad tablet and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The present embodiment provides a spinosad tablet, which consists of two layers of an immediate-release layer and a sustained-release layer. The total content of the spinosad in the immediate-release layer and the sustained-release layer is 7.5%, and the tablet weight is 1.33g. The immediate release layer is 0.2g, and the sustained release layer is 1.13g. The formulations of the immediate-release layer and the sustained-release layer per 100 parts are as follows:

[0048] Immediate release layer (100 parts): 5 parts of spinosad, 10 parts of PEG, 7 parts of sodium bicarbonate, 7 parts of citric acid, 1 part of sodium polyphosphate, 1 part of lignosulfonate, 0.8 parts of polyvinylpyrrolidone, Carboxymethyl starch sodium 2 parts, lactose added to 100 parts;

[0049] Sustained release layer (100 parts): spinosad 8 parts, calcium sulfate 24 parts, PEG 7 parts, naphthalene sulfonate 1 part, lignosulfonate 1 part, polyvinylpyrrolidone 0.8 part, white carbon black 2 parts , s...

Embodiment 2

[0053] The present embodiment provides a spinosad tablet, which is composed of two layers of an immediate-release layer and a sustained-release layer, the total content of the spinosad in the immediate-release layer and the sustained-release layer is 6.25%, and the tablet weight is 1.33g. The immediate release layer is 0.2g, and the sustained release layer is 1.13g. The formulations of the immediate-release layer and the sustained-release layer per 100 parts are as follows:

[0054] Immediate release layer (100 parts): 2 parts of spinosad, 10 parts of PEG, 7 parts of sodium bicarbonate, 7 parts of citric acid, 1 part of sodium polyphosphate, 1 part of lignosulfonate, 0.7 parts of polyvinylpyrrolidone, Carboxymethyl starch sodium 2 parts, lactose added to 100 parts;

[0055] Sustained release layer (100 parts): spinosad 7 parts, calcium sulfate 14 parts, PEG 7 parts, naphthalene sulfonate 1 part, lignosulfonate 1 part, polyvinylpyrrolidone 0.8 part, white carbon black 2 parts ...

experiment example 1

[0068] The release analysis of experimental example 1 spinosad tablet

[0069] The spinosad tablets of Examples 1~2 and Comparative Examples 1~4 are placed in water, utilize HPLC to detect the content of spinosad at different times, analyze the release rate of spinosad tablets over time, the result As shown in Table 1 and figure 1 shown.

[0070] The release rate of table 1 spinosyn tablet

[0071]

[0072] The results show that, adopting the slow-release carriers of Comparative Examples 1 and 2, the slow-release effect of spinosad tablets is significantly reduced, wherein, only calcium sulfate is used as the slow-release carrier, the initial spinosad releases faster, and the spinosad The release of spinosad into the water is premature, and the content in the water is very low in the later stage, and the insecticidal effect is greatly reduced; the release rate of calcium sulfate combined with stearic acid is slow, and spinosad is partially decomposed in water, and the ins...

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Abstract

The invention relates to the technical field of mosquito control, in particular to a spinosad tablet and its preparation method and application. The spinosyn tablet consists of a sustained-release layer and an immediate-release layer. The immediate-release layer can disintegrate quickly after being put into water, release spinosad and effectively diffuse in water to play a mosquito-killing effect; while the slow-release layer can protect the activity and stability of spinosad in water, and release slowly and for a long time Spinosad can prevent and control mosquitoes in water bodies for a long time, greatly reduce the amount of drugs used and the number of injections required for mosquito control in water, and reduce the impact on the environment.

Description

technical field [0001] The invention relates to the technical field of mosquito control, in particular to a spinosad tablet for preventing and controlling mosquitoes in water bodies, a preparation method and application thereof. Background technique [0002] Mosquitoes are sanitary pests that do great harm to humans. After mating, the blood-sucking mosquitoes need to find a host to suck blood, and then spread various diseases including malaria and dengue fever. After sucking blood, the female will lay eggs in the water or the edge of the water area. The mosquito eggs can only hatch in the water. The mosquito larvae live in the water and breathe air on the water surface through the air valve. [0003] The use of traditional chemical insecticides to control mosquitoes has disadvantages such as high pollution and easy resistance. Therefore, mosquito control needs to be developed in the direction of high efficiency, low toxicity, no pollution, and no damage to the ecological env...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/22A01N25/34A01P7/04
CPCA01N43/22A01N25/34
Inventor 周海燕杜贵生班鹍鹏邵帅
Owner BEIJING MULTIGRASS FORMULATION
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