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Intravascular stent overlay film for in-situ intima regeneration and preparation method of intravascular stent overlay film

A vascular stent, in situ technology, applied in the field of vascular stent covering for in situ intimal regeneration and its preparation, can solve the problems of slippage and lack of histocompatibility, and achieve excellent flexibility and excellent tensile properties , the effect of excellent cytocompatibility

Active Publication Date: 2020-12-08
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The covering materials currently used clinically do not have excellent histocompatibility, and long-term postoperative restenosis is prone to occur, and complications such as slippage also occur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] This implementation case shows a method for preparing a vascular stent covering for in situ intimal regeneration, including:

[0025] 1. Twisting and merging silkworm raw silk to obtain a 120D silk thread group, and the other group is a silk monofilament group. Put the silk monofilament group and silk thread group in a bath ratio of 1:50 (g / mL) at a concentration of 0.1-0.6% In a sodium carbonate aqueous solution, treat it three times at 98-100°C for 30 minutes each time, then fully wash the silk with deionized water, and dry it in an oven at 60°C to obtain degummed silkworm silk fiber and cooked silk thread .

[0026] 2. Weigh the degummed silkworm silk fiber and dissolve it in 9.3M lithium bromide aqueous solution at a bath ratio of 1:10 (g / mL), and treat it at 65°C until the degummed silkworm silk fiber is completely dissolved to obtain silkworm silk lysate. The silkworm fibroin solution is poured into the dialysis bag. The wall of the dialysis bag is a semipermeab...

Embodiment 2

[0032] This implementation case shows a method for preparing a vascular stent covering for in situ intimal regeneration, including:

[0033] 1. Twisting and merging silkworm raw silk to obtain a 120D silk thread group, the other group is a silk monofilament group, put the silk monofilament group and silk thread group at a bath ratio of 1:50 (g / mL) at a concentration of 0.1-0.6% In a sodium carbonate aqueous solution, treat it three times at 98-100°C for 30 minutes each time, then fully wash the silk with deionized water, and dry it in an oven at 60°C to obtain degummed silkworm silk fiber and cooked silk thread .

[0034] 2. Weigh the degummed silkworm silk fiber and dissolve it in 9.3M lithium bromide aqueous solution at a bath ratio of 1:10 (g / mL), and treat it at 65°C until the degummed silkworm silk fiber is completely dissolved to obtain silkworm silk lysate. The silkworm fibroin solution is poured into the dialysis bag. The wall of the dialysis bag is a semipermeable m...

Embodiment 3

[0040] This implementation case shows a method for preparing a vascular stent covering for in situ intimal regeneration, including:

[0041] 1. Twisting and merging silkworm raw silk to obtain a 120D silk thread group, the other group is a silk monofilament group, put the silk monofilament group and silk thread group at a bath ratio of 1:50 (g / mL) at a concentration of 0.1-0.6% In a sodium carbonate aqueous solution, treat it three times at 98-100°C for 30 minutes each time, then fully wash the silk with deionized water, and dry it in an oven at 60°C to obtain degummed silkworm silk fiber and cooked silk thread .

[0042] 2. Weigh the degummed silkworm silk fiber and dissolve it in 9.3M lithium bromide aqueous solution at a bath ratio of 1:10 (g / mL), and treat at 65°C until the silkworm silk fiber is completely dissolved to obtain silkworm silk fibroin solution. The silkworm fibroin solution is poured into the dialysis bag. The wall of the dialysis bag is a semipermeable memb...

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Abstract

The invention discloses an intravascular stent overlay film for in-situ intima regeneration and a preparation method of the intravascular stent overlay film. The method comprises the following steps:dividing silkworm natural silk into two groups, performing twisting and combining into silk thread groups, taking the other group as a monofilament group, performing degumming, performing dissolving in a lithium bromide neutral salt solution to prepare a silk fibroin dissolving solution, and then pouring the silk fibroin dissolving solution into a dialysis bag with a certain molecular weight cut-off; performing dialyzing to obtain a purified silkworm silk fibroin aqueous solution, and then concentrating the silk fibroin to a proper mass fraction by adopting a rotary evaporator; adding a hydrophilic flexible molecule cross-linking agent into the silk fibroin aqueous solution, performing uniform mixing, removing bubbles to obtain a modified silk fibroin solution, knitting monofilaments intoa tubular structure by adopting a knitting machine, performing coating to the fibroin tubular structure, performing rotary air drying on each coating in the circumferential direction under low-temperature hot air, and controlling the coating to be a uniform molecular layer, so as to obtain the intravascular stent overlay film for in-situ intima regeneration. The overlay film has excellent toughness, and in-situ induction of endovascular regeneration for regulating balance of a blood system is realized.

Description

technical field [0001] The invention relates to the technical field of preparation of vascular stent coverings, in particular to a vascular stent covering for in situ intima regeneration and a preparation method thereof. Background technique [0002] With the improvement of living standards and the acceleration of the aging process, the incidence of cardiovascular and cerebrovascular diseases is increasing significantly year by year. Cardiovascular and cerebrovascular diseases such as embolism, vascular stenosis, and vascular aneurysm seriously threaten human health and have become human mortality. highest etiology. With the development of medicine, minimally invasive endovascular isolation has gradually become the main treatment method for various arterial lesions due to the small surgical trauma. Vascular covered stent is the main body of endoluminal isolation, and its performance directly affects the clinical treatment effect. However, complications such as slippage of v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/14A61L31/16A61L27/34A61L27/54A61L27/58C07K14/435
CPCA61L31/10A61L31/16A61L31/14A61L31/148A61L27/34A61L27/54A61L27/58C07K14/43586A61L2300/252A61L2300/42A61L2300/412A61L2300/606A61L2420/08C08L89/00
Inventor 宋广州王建南裔洪根许建梅
Owner SUZHOU UNIV
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