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Autocatalytic antibacterial agent of polysaccharide-based nanodot aggregate and preparation method and application of autocatalytic antibacterial agent

A technology of nano-dots and aggregates, applied in the field of antibacterial nanometers, can solve the problems of poor antibacterial effect and large side effects, and achieve the effects of good biocompatibility, fast synthesis time, and reduction of excess toxicity.

Active Publication Date: 2020-12-11
NORTHWEST A & F UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem of poor antibacterial effect and large side effects caused by the low permeability of the existing nano-antibacterial agents to bacterial biofilms, and provide a pH-responsive dextran-modified copper peroxide nano-dot Aggregate antibacterial agent and its preparation method and application

Method used

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  • Autocatalytic antibacterial agent of polysaccharide-based nanodot aggregate and preparation method and application of autocatalytic antibacterial agent
  • Autocatalytic antibacterial agent of polysaccharide-based nanodot aggregate and preparation method and application of autocatalytic antibacterial agent
  • Autocatalytic antibacterial agent of polysaccharide-based nanodot aggregate and preparation method and application of autocatalytic antibacterial agent

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specific Embodiment approach 1

[0054] Specific implementation mode one: combine figure 1 To illustrate this embodiment, this embodiment is a self-catalyzed antibacterial agent of a polysaccharide-based nano-dot aggregate that releases Cu under acidic conditions. 2+ and H 2 o 2 , the Fenton reaction occurs to generate OH with catalytic activity, and does not release Cu under neutral or alkaline conditions 2+ and H 2 o 2 ; The self-catalyzed antibacterial agent of the polysaccharide-based nano-dot aggregate is composed of CuCl 2 、H 2 o 2 , NaOH and dextran as raw materials.

specific Embodiment approach 2

[0055] Specific embodiment two: the differences between this embodiment and specific embodiment one are: the pH value of the acidic condition is 5.6; the CuCl 2 The molar ratio with NaOH is 1:1. Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0056] Specific embodiment three: This embodiment is a preparation method of a self-catalyzed antibacterial agent of polysaccharide-based nano-dot aggregates, which is completed in the following steps:

[0057] 1. Add dextran to CuCl 2 solution, and then stirred until the dextran was completely dissolved to obtain dextran / CuCl 2 solution;

[0058] 2. To dextran / CuCl 2 NaOH solution was added to the solution, followed by H 2 o 2 solution, stirred and reacted to obtain a solution containing dextran-modified copper peroxide nano-dot aggregates;

[0059] Dextran / CuCl as described in step 2 2 CuCl in solution 2 The molar ratio with NaOH in NaOH solution is 1:1;

[0060] 3. Using absolute ethanol as a cleaning agent, the solution containing dextran-modified copper peroxide nano-dot aggregates is centrifugally cleaned to obtain a self-catalyzed antibacterial agent solution of polysaccharide-based nano-dot aggregates.

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Abstract

The invention discloses an autocatalytic antibacterial agent of a polysaccharide-based nanodot aggregate and a preparation method and application of the autocatalytic antibacterial agent, belongs to the technical field of antibacterial nanotechnology, and relates to an antibacterial agent as well as a preparation method and application of the antibacterial agent. The invention aims to solve the problems of poor antibacterial effect and large side effect caused by low permeability of the existing nano antibacterial agent to a bacterial biofilm. The autocatalytic antibacterial agent of the polysaccharide-based nanodot aggregate releases Cu < 2 + > and H2O2 under acidic conditions, generates Fenton reaction to generate. OH with catalytic activity, and does not release Cu < 2 + > and H2O2 under neutral or alkaline conditions. The method comprises the following steps: 1, preparing a glucan / CuCl2 solution; 2, adding a NaOH solution and a H2O2 solution, and carrying out a stirring reaction; 3, centrifugal cleaning. The autocatalytic antibacterial agent of the polysaccharide-based nanodot aggregate releases. . OH with catalytic activity under an acidic condition, and is used for killing bacteria, inhibiting the formation of a bacterial biofilm and removing the formed biofilm.

Description

technical field [0001] The invention belongs to the field of antibacterial nanotechnology, and relates to an antibacterial agent and its preparation method and application. Background technique [0002] About 700,000 patients worldwide die from pathogenic bacterial infection every year, which makes pathogenic bacterial infection the second leading cause of death in the world and has aroused widespread concern in the health field. Among them, the formation of biofilm plays an important role in most bacterial infection diseases. Biofilms are complex multicellular aggregates in which microbial cells are embedded in a self-generating matrix of extracellular polymers, including proteins, polysaccharides, extracellular nucleic acid (eDNA) and cellular debris, commonly found on tissue surfaces as well as medical devices such as Catheters, pacemakers and artificial joints, causing chronic infection. The special structure of the biofilm provides a protective barrier for the bacteri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/20A01N59/00A01P1/00
CPCA01N59/00A01N59/20
Inventor 张文涛李敏王建龙蓝熙韩希美石硕
Owner NORTHWEST A & F UNIV
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