Prebiotic compositions and methods for maintaining a healthy skin microbiota

A technology of microbiota and composition, applied in the direction of drug combination, skin care preparations, skin diseases, etc., can solve the problems of host skin bacteria overgrowth, destroying the natural relationship of natural skin microbiota, etc.

Pending Publication Date: 2020-12-18
KIMBERLY-CLARK WORLDWIDE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of certain existing prebiotics can lead to overgrowth among host skin bacteria and thus can disrupt natural relationships within the natural skin microbiota

Method used

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  • Prebiotic compositions and methods for maintaining a healthy skin microbiota
  • Prebiotic compositions and methods for maintaining a healthy skin microbiota
  • Prebiotic compositions and methods for maintaining a healthy skin microbiota

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0198] Embodiment 1: A composition for providing or maintaining a healthy skin microbiota comprising: a carrier; and a skin microbiota balancing agent comprising at least one carbohydrate source In combination, the carbohydrate source comprises a first carbohydrate source and a second carbohydrate source, wherein the skin microbiota balancing agent is configured to provide at least two of the following desired ratios: the first desired ratio of Corynebacterium and Staphylococcus, a second desired ratio of Corynebacterium to Micrococcus, and a third desired ratio of Staphylococcus to Micrococcus.

Embodiment approach 2

[0199] Embodiment 2: The composition of Embodiment 1, wherein the first desired ratio of Corynebacterium to Staphylococcus is 1.3, the second desired ratio of Corynebacterium to Micrococcus is 1.4, and The third desired ratio of Staphylococcus to Micrococcus is 1.1.

Embodiment approach 3

[0200]Embodiment 3: The composition of Embodiment 1 or 2, wherein at least one combination of carbohydrate sources is selected from the group consisting of: D-alanine + gamma-cyclodextrin, D- Alanine + sebacic acid, D-alanine + 2,3-butanediol, D-aspartic acid + oxalic acid, D-aspartic acid + pectin, D-threonine + 3-methyl Glucose, D-threonine + pectin, fumaric acid + α-cyclodextrin, fumaric acid + mannan, L-alanyl-glycine + 3-methylglucose, L-alanyl-glycine + oxalic acid, L-alanyl-glycine + pectin, L-malic acid + mannan, D-glucaric acid + pectin + L-alanine, succinic acid + 3-methylglucose + D-glucosamine acid, Succinic acid + 3-methylglucose + L-alanine, succinic acid + 3-methylglucose + glycyl-L-aspartic acid, succinic acid + pectin + D-glucosamine acid, succinic acid + Pectin+Glycyl-L-Aspartic Acid, Tween 40+3-Methylglucose+D-Glucosamine Acid, Tween 40+3-Methylglucose+L-Alanine, Tween 40+ 3-Methylglucose+Glycyl-L-Aspartic Acid, Tween 40+Pectin+D-Glucosamine Acid, Tween 40...

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PUM

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Abstract

A composition for providing or maintaining a healthy skin microbiota and methods of providing or maintaining a healthy skin microbiota are disclosed. The composition can be a prebiotic composition that can include a carrier and a skin microbiota balancing agent. In some aspects, the skin microbiota balancing agent can include at least one combination of carbohydrate sources including a first carbohydrate source and a second carbohydrate source. The skin microbiota balancing agent can be configured to provide at least two of the following desired ratios: a first desired ratio of Corynebaderiumto Staphylococcus of 1.3, a second desired ratio of Corynebaderium to Micrococcus of 1.4, and a third desired ratio of Staphylococcus to Micrococcus of 1.1. The carbohydrate sources may be D-alanine,D-threonine, L-alanyl-glycine, succinic acid, alpha-keto-glutaric acid, m-tantaric acid, bromo succinic acid, mucic acid, phenylethyl-amine, inulin, oxalic acid, pectin, Tween 40 etc.

Description

Background technique [0001] Human skin functions as the primary physical barrier that protects the body from the external environment. This biological interface includes a variety of bacteria and fungi that help maintain the barrier function provided by the skin. Skin is thought to be low in abundance but high in bacterial diversity. This high diversity of bacteria establishes a complex relationship between resident bacteria, transient bacteria, the interactions between these bacteria, and the host's skin and immune system. These relationships are important to skin health. [0002] Many factors can affect skin health. Both intrinsic factors, such as host genetics and skin biochemistry, as well as extrinsic factors, such as hygiene practices and host environmental conditions, can shift the skin microbiota from a typical to a dysregulated state, which can lead to disruption of the skin barrier and potentially disease . The healthy skin microbiota is composed of diverse bact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/185A61K31/715A61K8/33A61Q19/00A61P17/00A61F13/15A61F13/49
CPCA61P17/00A61Q19/00A61K8/60A61K8/44A61K45/06A61F13/51113A61F13/84A61L15/44A61L2300/214A61K8/0212A61K8/06A61L15/225A61L2300/23A61F2013/51117A61K8/345A61K8/362A61K8/365A61K8/415A61K8/602A61K8/73A61K8/738A61L15/20A61L15/28A61L15/42A61L2300/204A61L2300/21A61L2300/232
Inventor E·M·多尼D·W·凯尼格J·霍夫梅克勒
Owner KIMBERLY-CLARK WORLDWIDE INC
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