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Medicine for treating postoperative abdominal adhesion, and new use of medicine

A drug and intraperitoneal technology, applied in the field of medicine, can solve problems such as poor actual effect of intraperitoneal adhesion, and achieve the effects of reducing economic burden, reducing complications, and reducing average thickness

Pending Publication Date: 2020-12-25
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0004] In order to solve the current situation that there is no effective drug to prevent and treat postoperative peritoneal adhesions, the present invention applies recombinant human endostatin, which is used for clinical targeted therapy of non-small cell lung cancer and adjuvant treatment of other malignant tumors, to postoperative peritoneal adhesions for the first time. Prevention and treatment, to solve the current technical problems such as the poor actual effect of prevention and treatment of postoperative abdominal adhesions

Method used

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  • Medicine for treating postoperative abdominal adhesion, and new use of medicine
  • Medicine for treating postoperative abdominal adhesion, and new use of medicine
  • Medicine for treating postoperative abdominal adhesion, and new use of medicine

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Experimental program
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Effect test

Embodiment 1

[0033] 1. Materials and methods

[0034] 1.1 Animals

[0035] 32 healthy female SD rats, weighing 230-270 g (certificate number SCXK-(Xiang) 2016-0002), were purchased from Hunan Slack Jingda Experimental Animal Co., Ltd., and were fostered in the barrier system of the Department of Experimental Animals, Central South University. . Before the experiment, the rats were adapted to the environment under standard experimental conditions for 7 days, given standard animal feed and water, and the ambient temperature was maintained at 20-26° C., and the relative humidity was 30%-70%. The experimental process followed the principles of humanism to ensure the welfare and ethics of experimental animals. All animal experimental procedures were submitted to the Experimental Animal Welfare Ethics Committee of Central South University for approval and completed in the Department of Experimental Zoology of Central South University.

[0036] 1.2 Drugs and reagents

[0037] Recombinant human...

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Abstract

The invention discloses a medicine for treating the postoperative abdominal adhesion. The medicine is recombinant human endostatin, the recombinant human endostatin is administrated in an injection manner, and the medicine is applied as a medicine for treating the postoperative abdominal adhesion. The medicine can effectively reduce the postoperative abdominal adhesion, which is the most common complication after an abdominal surgery, and reduces complications of the abdominal adhesion. The cure rate of abdominal operations is improved, and the economic burden caused by the abdominal adhesionis reduced.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a new application of recombinant human endostatin, in particular to a drug for treating postoperative abdominal adhesion and its new application. Background technique [0002] Abdominal adhesions refer to the fibrous adhesions mainly covered with collagen between the abdominal organs or between the organs and the peritoneum after the abdomen is stimulated by surgical injury, ischemia, infection or foreign bodies. It is the most common after abdominal surgery. one of the complications. Among the patients undergoing abdominal surgery, more than 90% of them will have intra-abdominal adhesions. Complications of intra-abdominal adhesions mainly include chronic abdominal pain, recurrent intestinal obstruction, and female infertility, among which intestinal obstruction is the most common complication, with a mortality rate close to 10%. According to literature reports, during diagnosti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P41/00A61P29/00
CPCA61K38/1709A61K9/0019A61P41/00A61P29/00
Inventor 胡桂林昌伟郭一航谌敏贞
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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