Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of 3-n-butyl-isoindolin-1-one in preparation of medicine for preventing and treating senile dementia

A technology for senile dementia and isoindoline, which is applied in the field of medicine and can solve the problems of chemically synthesized drugs with high toxicity and side effects

Pending Publication Date: 2020-12-29
SUN YAT SEN UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the above-mentioned drugs can play an active role in the treatment of Alzheimer's disease, but the chemically synthesized drugs also have great toxic and side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of 3-n-butyl-isoindolin-1-one in preparation of medicine for preventing and treating senile dementia
  • Application of 3-n-butyl-isoindolin-1-one in preparation of medicine for preventing and treating senile dementia
  • Application of 3-n-butyl-isoindolin-1-one in preparation of medicine for preventing and treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation of 3-n-butyl-isoindoline-1-one tablet

[0030] 【prescription】

[0031]

[0032]

[0033] Accurately weigh 3-n-butyl-isoindolin-1-one with constant weight according to the prescription amount, grind it into powder, pass through a 100-mesh sieve, and set aside. Accurately weigh the starch with a constant weight and pass through a 100-mesh sieve. Mix the sieved 3-n-butyl-isoindolin-1-one and starch evenly, add an appropriate amount of 50% ethanol to make a soft material, granulate through a 18-mesh nylon sieve, dry at 60-70°C, and use 18 Mesh sieve for granulation, then add sodium carboxymethyl starch and magnesium stearate, and mix well. Φ8mm punching die pressing tablet.

Embodiment 2

[0034] Example 2 Preparation of 3-n-butyl-isoindoline-1-one hard capsules

[0035] 【prescription】

[0036]

[0037] The wet granulation method is the same as in Example 1. Accurately weigh 3-n-butyl-isoindolin-1-one with constant weight according to the prescription amount, grind it into powder, pass through a 100-mesh sieve, and set aside. Accurately weigh the starch with a constant weight and pass through a 100-mesh sieve. Mix the sieved 3-n-butyl-isoindolin-1-one and starch evenly, add an appropriate amount of 50% ethanol to make a soft material, granulate through a 18-mesh nylon sieve, dry at 60-70°C, and use 18 Mesh sieve for granulation, test the content, and pack into No. 1 capsule after passing the test.

Embodiment 3

[0038] Example 3 Preparation of 3-n-butyl-isoindoline-1-one soft capsules

[0039] Take 1 g of the prepared 3-n-butyl-isoindolin-1-one, 10 g of vegetable oil, and 1 g of polyglyceric acid ester, mix them, put them in a ball mill and mix them evenly to obtain the contents of soft capsules. Using gelatin: glycerin: water: opacifying agent = 1:0.4:0.8:0.01 as the capsule material, the soft capsules are prepared by molding method, the soft capsules are cured by cold air, dried, washed with an appropriate solvent, and finally dried to obtain 100 soft capsules. grain.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of a compound 3-n-butyl-isoindolin-1-one shown as a general formula I in preparation of a medicine for preventing and treating senile dementia. The 3-n-butyl-isoindolin-1-one can obviously prolong the passive avoidance time of a model mouse with senile dementia caused by D-galactose, and based on the fact that the compound has the effects of treating focal cerebral ischemia and improving brain metabolism, it is preliminarily believed that the 3-n-butyl-isoindolin-1-one has a certain prevention and treatment effect on senile dementia, and has great significance for the clinical treatment of senile dementia. In the meanwhile, the compound is of a solid crystal structure, compared with 3-butyl -1-isobenzofuranone which is similar to the compound but has anoily liquid form, the compound has higher freedom in the aspect of preparations, more choices are provided for clinical medication, and the medication cost is reduced.

Description

Technical field: [0001] The invention belongs to the field of compound medicine, in particular to 3-n-butyl-isoindoline-1-one and a pharmaceutical composition containing 3-n-butyl-isoindoline-1-one in the preparation of prevention and treatment of senile Drug use in dementia. Background technique: [0002] Alzheimer's disease, also known as Alzheimer's disease, is a degenerative disease of the central nervous system. Its clinical manifestations are deteriorating cognitive and memory functions. Serious burdens on families and society. According to statistics, the number of cases of dementia in the United States in 2000 was 4.5 million cases, and the percentage of dementia patients will increase by 2 times for every 5 years of age increase. At present, there are about 129 million elderly people over 60 years old in my country, and the aging population is getting higher and higher at this stage, and the prevalence of Alzheimer's disease is also showing an upward trend, becaus...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4035A61P25/28
CPCA61K31/4035A61P25/28
Inventor 赵春顺兰祖枧
Owner SUN YAT SEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com