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Florfenicol soluble powder and preparation method thereof

A florfenicol and soluble technology, which is applied in the field of florfenicol soluble powder and its preparation, can solve the problems that florfenicol cannot be administered through drinking water, cannot exert maximum curative effect, and reduce animal absorption rate, etc. The effect of improving bioavailability, significant curative effect, and improving palatability

Inactive Publication Date: 2021-01-08
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problems that florfenicol cannot be administered through drinking water, greatly reduces the absorption rate of animals, reduces its bioavailability, and cannot exert its maximum curative effect, etc., and provides a florfenicol Soluble powder and its preparation method

Method used

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  • Florfenicol soluble powder and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] A florfenicol soluble powder in this embodiment includes raw materials per 100 g: 10 g of florfenicol, 20 g of beta-cyclodextrin, 2 g of poloxamer, and the rest are fillers.

[0021] When preparing, include the following steps:

[0022] (1) Dry the beta-cyclodextrin at 105°C for 8 hours, and control the weight loss on drying within 3.0%;

[0023] (2) Weigh the dried beta-cyclodextrin, dissolve it in an appropriate amount of hot water at 60°C, add 2g of poloxamer, and stir evenly;

[0024] (3) Add 10 g of Florfenicol again, keep the temperature at 60° C., and stir to dissolve;

[0025] (4) When the florfenicol is completely dissolved, add the filler and stir to dissolve;

[0026] (5) Start up the preheating spray tower, after setting parameters, the solution obtained in step (4) is spray-dried;

[0027] (5) Collect the powder in step (5) to finally obtain Florfenicol soluble powder.

Embodiment 2

[0029] A florfenicol soluble powder in this embodiment includes raw materials per 100 g: 30 g of florfenicol, 40 g of methyl beta-cyclodextrin, 5 g of poloxamer, and the rest are fillers.

[0030] When preparing, include the following steps:

[0031] (1) Dry the beta-cyclodextrin at 105°C for 8 hours, and control the weight loss on drying within 3.0%;

[0032] (2) Weigh the dried beta-cyclodextrin, dissolve it in an appropriate amount of hot water at 60°C, add 5g of polysorbate 80, and stir evenly;

[0033] (3) Add 10 g of Florfenicol again, keep the temperature at 60° C., and stir to dissolve;

[0034] (4) When the florfenicol is completely dissolved, add the filler and stir to dissolve;

[0035] (5) Start up the preheating spray tower, after setting parameters, the solution obtained in step (4) is spray-dried;

[0036] (5) Collect the powder in step (5) to finally obtain Florfenicol soluble powder.

Embodiment 3

[0038] Comparative example 1 in this embodiment is the purchase of florfenicol soluble powder from A Co., Ltd. on the market, and comparative example 2 is the purchase of florfenicol soluble powder from B Biotechnology Co., Ltd. on the market. In order to verify the chemical properties of Florfenicol soluble powder prepared by the present invention and comparative examples, carry out following test:

[0039] Get the samples of Example 1-2 and Comparative Example 1-2, respectively configure them into 0.4mg / ml (calculated by Florfenicol content) solution, under the condition of 25±2°C, turn them upside down 10 times and let stand, respectively Observe the dissolution properties at 0, 1, 2, 3, 6, 12, 24, and 48 hours. According to the detection method of florfenicol soluble powder in the 2015 edition of "Chinese Veterinary Pharmacopoeia", the experimental results obtained are as follows.

[0040] Table 1 Solution properties

[0041] 0h 1h 2h 3h 6h 12h 24h 48h ...

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Abstract

The invention discloses florfenicol soluble powder and a preparation method thereof. Every 100 parts of the florfenicol soluble powder comprises the following raw materials in parts by weight: 5-30 parts of florfenicol, 10-60 parts of an inclusion compound, 2-10 parts of a cosolvent and the balance a filling agent. By adopting an inclusion technique, the florfenicol soluble powder is prepared through spray drying; the inclusion compound is dried for 8-12 hours and is subsequently used, so that the inclusion space of the inclusion compound is increased, the bad smell and the bitter taste of theinclusion compound are covered, the palatability of conventional florfenicol soluble powder is improved, the solubility of the florfenicol soluble powder is improved, active components are stably released, and thus the bioavailability is improved; and the florfenicol soluble powder disclosed by the invention is high in solubility, good in flowability, low in moisture and good in stability, and the quality of the florfenicol soluble powder is far higher than that of veterinary drug quality standards.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparations, in particular to florfenicol soluble powder and a preparation method thereof. Background technique [0002] Florfenicol is also known as fluprofen and florfenicol. It belongs to the broad-spectrum antimicrobials of amidoalcohols. It is a special antibiotic for animals. It is used for the bacterial diseases of chickens, pigs and fish caused by sensitive bacteria. It is especially effective in respiratory system infection and intestinal infection. It is widely used in clinical practice. . With the large scale of pig raising and the wide application of granular feed, the convenience, timeliness and flexibility of drinking water administration have become increasingly prominent. At present, when the drug is administered in drinking water, it is often used to prepare 10-20 times the clinical dosage, dissolve and clarify, and then dilute to the clinical dosage through a pressuriz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/69A61K47/10A61K31/165A61P31/04
CPCA61K9/146A61K47/6951A61K31/165A61P31/04
Inventor 熊玲玲
Owner HUBEI LONGXIANG PHARMA TECH CO LTD