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Method for catalytically synthesizing lactide

A technology for lactide and compound, applied in the field of catalyzing and synthesizing lactide, can solve the problems of high catalytic reaction temperature and large energy consumption, and achieve the effects of low reaction temperature, high yield and short reaction time

Active Publication Date: 2021-01-22
南京兴威生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Purpose of the invention: the technical problem to be solved by this invention is to provide a high-efficiency energy-saving catalytic synthesis for the problems of high catalytic reaction temperature and high energy consumption in the existing synthetic L-lactide (or D-lactide) technology. lactide method

Method used

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  • Method for catalytically synthesizing lactide
  • Method for catalytically synthesizing lactide
  • Method for catalytically synthesizing lactide

Examples

Experimental program
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Effect test

Embodiment 1

[0024] 1) Mix stannous lactate and urea at a molar ratio of 2:1, heat and stir at 80°C and 500r / min to form a composite catalyst;

[0025] 2) Add 150 g of L-lactic acid oligomers with a weight-average molecular weight of about 500 Da to the reaction flask, and add the composite catalyst prepared in step (1) into the lactic acid oligomers. The ratio is 1:100, the reaction temperature is controlled at 180°C and the vacuum degree is 5 torr, and the reaction is carried out for 2 hours. The yield of L-lactide is 93.15%, and the purity is 96.68%.

Embodiment 2

[0027] 1) Mix stannous lactate and thiourea at a molar ratio of 1:6, heat and stir at 90°C and 100r / min to form a composite catalyst;

[0028] 2) Add 150 g of L-lactic acid oligomers with a weight-average molecular weight of about 3000 Da to the reaction flask, and add the composite catalyst prepared in step (1) into the lactic acid oligomers. The ratio is 1:3000, the reaction temperature is controlled at 170°C and the vacuum degree is 1 torr, and the reaction is carried out for 0.5 hours. The yield of L-lactide is 90.03%, and the purity is 97.52%.

Embodiment 3

[0030] 1) Mix stannous lactate and 1,3-dimethylurea at a molar ratio of 1:3, heat and stir at 80°C and 300r / min to form a composite catalyst;

[0031] 2) Add 150 g of L-lactic acid oligomers with a weight-average molecular weight of about 1500 Da to the reaction flask, and add the composite catalyst prepared in step (1) into the lactic acid oligomers. The ratio is 1:1500, the reaction temperature is controlled at 175°C and the vacuum degree is 3 torr, and the reaction is carried out for 1 hour. The yield of L-lactide is 92.45%, and the purity is 98.66%.

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Abstract

The invention discloses a method for catalytically synthesizing lactide. According to the method, a mixture of stannous lactate and a urea substance is used as a composite catalyst, L-lactic acid (orD-lactic acid) with the lactic acid content of 90% is used as a raw material, and a reduced pressure distillation technology is adopted to synthesize the L-lactide (or D-lactide). Compared with independent use of onecatalyst, by adopting the composite catalyst, the yield can be effectively increased, under the same experimental conditions, the crude yields of lactide synthesized by independently using stannous lactate or urea catalysts are 69%-72% and 23%-30% respectively, and the yield can be increased to 90% or above by using the composite catalyst of the two. Compared with a traditional tincatalyst or zinc catalyst and other composite catalytic components, the composite catalytic reaction system is low in reaction temperature (150-180 DEG C), short in reaction time (0.5-2 h), high in lactide yield (90% or above), capable of saving more energy and increasing the yield and beneficial to industrial production.

Description

technical field [0001] The invention belongs to the field of environmentally friendly materials, in particular to a method for catalytically synthesizing lactide. Background technique [0002] Environmental problems such as "white pollution" caused by petroleum-based plastics are becoming more and more serious. Polylactic acid, as a kind of biodegradable plastics, can be completely degraded by microorganisms under certain time and conditions, and is considered to be an effective alternative to petroleum-based plastics. One of the alternatives. At present, the synthesis of polylactic acid mainly adopts the method of ring-opening polymerization. As lactide is an important monomer for the synthesis of polylactic acid by ring-opening polymerization, the research on its synthesis method is very important. [0003] At present, the synthesis of lactide mainly uses metal catalysts (such as stannous octoate, zinc oxide, etc.) industrialized production. Contents of the invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D319/12B01J31/04B01J31/06
CPCC07D319/12B01J31/04B01J31/0249B01J31/06B01J35/19
Inventor 江伟卢珂张延凯孙平李爱民张全兴
Owner 南京兴威生物技术有限公司
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