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Composition for improving conception rate of ruminants as well as preparation method and application thereof

A technology for ruminants and compositions, which is applied in the direction of drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as high processing requirements, damage to cows, long processing time, etc., to achieve Strong operability, increase pregnancy rate, and promote luteinization effect

Inactive Publication Date: 2021-02-02
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in practical applications, these solutions require high treatment requirements and long treatment time. At the same time, a large number of drugs such as GnRH and its analogs will cause corresponding damage to the cow body: such as ovulation inhibition, gonadal atrophy, etc.

Method used

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  • Composition for improving conception rate of ruminants as well as preparation method and application thereof
  • Composition for improving conception rate of ruminants as well as preparation method and application thereof
  • Composition for improving conception rate of ruminants as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1. Melatonin injection preparation method

[0052] Raw materials: melatonin, absolute ethanol.

[0053] Preparation method: accurately weigh 1.5g of melatonin, dissolve it in a 100mL volumetric flask with absolute ethanol, stir evenly, then add 0.9% normal saline, stir evenly, and set the volume to 100mL (absolute ethanol: normal saline = 3: 2), prepared into a 15mg / mL solvent, and finally dispensed into a 2mL injection dose, and all operations were completed in a dark room.

Embodiment 2

[0054] Example 2. Synchronous ovulation timing insemination of dairy cows combined with the use of melatonin injection technology system

[0055] Cooperate with the injection of melatonin injection 2-3mL (such as figure 1 ), 32-35 days B-ultrasound pregnancy test or 60 days rectal grasp method for pregnancy test, and count the pregnancy rate.

Embodiment 3

[0056] Example 3. Analysis of the regulation and control of subcutaneous injection of melatonin on the reproductive hormones of dairy cows with synchronous ovulation

[0057] The same as in Example 2, the difference is that blood is collected at various stages from timing insemination to pregnancy detection during the same period of ovulation to measure changes in reproductive hormones related to ovulating dairy cows.

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Abstract

The invention discloses a composition for improving the conception rate of ruminants subjected to synchronization of ovulation and timed-insemination as well as a preparation method and application thereof. The effective component of the composition is melatonin with the concentration of 10-20 mg / mL. Animal experiments prove that when the composition provided by the invention is used together withinjection of GnRH at the last time in a synchronization of ovulation and timed-insemination program for ruminants, reproductive hormone in animal bodies can be regulated to secret, the content of luteinizing hormone LH and progesterone in pregnant female animals can be increased, which can improve ovum quality, promote ovulation, and then improve the conception rate of ruminants subjected to timed-insemination.

Description

technical field [0001] The invention relates to the field of animal husbandry and veterinary medicine, in particular to a composition for improving the pregnancy rate of ruminant synchronous ovulation and timing insemination, as well as its preparation method and application. Background technique [0002] In recent years, due to the gradual increase in the unit yield in the dairy farming industry, the breeding pregnancy rate of the dairy cows has shown a downward trend, and the calving intervals of dairy cows are long, which seriously affects the economic benefits. How to improve the reproductive efficiency of dairy cows has become an urgent task restricting the development of the industry. Timed Artificial Insemination (TAI) refers to a technology in which a group of dairy cows are in estrus and ovulate at the same period, and artificial insemination is performed regularly. This technology has good effect and high efficiency, and has been applied in many large pastures. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4045A61P15/08
CPCA61K31/4045A61P15/08A61K9/0019A61K47/10A61K9/08
Inventor 刘国世吴昊张鲁路永强王天坤郭江鹏姚松阳关盛宇姬鹏云
Owner CHINA AGRI UNIV
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