A kind of biomimetic hydrogel, its preparation method and application

Abstract

The invention discloses a bionic hydrogel, its preparation method and application. The biomimetic hydrogel has a three-dimensional network structure, which includes a polymer network skeleton and an evenly distributed airgel matrix loaded with antifreeze, and in the biomimetic hydrogel, the airgel matrix in the three-dimensional network structure The antifreeze agent loaded in the matrix can be released and interact with water molecules to inhibit the freezing of water molecules, and at the same time, the active functional adhesive groups in the polymer network skeleton can be exposed. The preparation method comprises: loading the antifreeze agent in the aerogel, and uniformly mixing the obtained aerogel loaded with the antifreeze agent and the polymer hydrogel precursor solution, and then adding a catalyst and a crosslinking agent, A high-temperature chemical cross-linking gel reaction is performed to obtain a biomimetic hydrogel. The biomimetic hydrogel of the invention can realize flexibility and viscosity at room temperature and low temperature while releasing the antifreezing agent; at the same time, the preparation process is simple, and it is easy to realize large-scale production.

Description

technical field [0001] The invention relates to a new type of gel material, in particular to a biomimetic hydrogel material with both antifreeze and viscosity and its preparation method and application, belonging to the technical field of gel materials and organic-inorganic composite materials. Background technique [0002] Hydrogel is a flexible polymer with a water content of up to 90%, which combines the mechanical properties of a solid and the migration properties of a liquid, can swell and retain a large amount of water and maintain a three-dimensional (3D) network structure. Hydrogels have good flexibility, adhesion, environmental sensitivity, swelling, melting, biocompatibility, and water absorption, as well as highly tunable mechanical, thermodynamic, and transport properties. Carriers, tissue scaffolds, sensors, 3D printing, soft robots, etc. have been widely used (CN2014100355118.9; CN104262880A). However, due to the high water content of the hydrogel, it may face...

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Problems solved by technology

However, due to the high water content of the hydrogel, it may face the following problems: (1) the hydrogel may freeze at a temperature below zero, thereby losing its ideal performance and limiting its application; (2) due to the hydrogel containing Large amounts of water may limit its viscous bonding properties

Viscous hydrogels have attracted great attention and achieved rapid development in biological applications. However, conventional hydrogels have limited the ability of polymer networks due to the good interaction between water molecules and polymer networks within the three-dimensional network. The active groups on the surface contact with the outside world, resulting in little or no viscosity in traditional hydrogels (Angewandte Chemie International Edition, 2014, 53(25), 6369-6373)

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