Oxidized black phosphorus nano material for osteoporosis

Abstract

The invention provides an oxidized black phosphorus nano material for osteoporosis, and particularly relates to the field of biomedicine. Black phosphorus crystals are obtained through liquid phase stripping; 25 mg of black phosphorus powder is dispersed into 25 ml of N-methylpyrrole, and ultrasonic crushing is conducted for 10 h; brown turbid liquid is centrifuged at 4,000 rpm for 8 min, and supernatant containing black phosphorus nanosheets is collected; the black phosphorus nanosheet solution is centrifuged under the condition of 12,000 rpm, then precipitate is collected, and afterwards, the black phosphorus nanosheet solution is re-suspended in deionized water, and stored at 4 DEG C in a dark place; and after the black phosphorus nanosheets are re-suspended in deionized water, the black phosphorus nanosheets are exposed to normal light at room temperature for a certain period t. The oxidized black phosphorus nano material is a novel diphosphonic acid preparation, can be used for inhibiting differentiation and formation of osteoclasts and playing a functional role without any influence on the activity of osteoblasts, so that osteoporosis is effectively treated. The unique property of the oxidized black phosphorus is effectively utilized, a remarkable osteoporosis treatment effect is both achieved in vivo and in vitro, and due to the fact that the material has excellent biocompatibility, the toxic influence on organisms is small.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a black phosphorus oxide nanometer material for osteoporosis. Background technique [0002] Due to its unique physicochemical properties and excellent biocompatibility, black phosphorus is an ideal candidate material in biosensing, drug delivery, photothermal therapy, and photodynamic therapy, among others. However, black phosphorus two-dimensional materials are often a few layers or even a single layer. When exposed to air, they are easily oxidized and degraded. The degradation products are relatively non-toxic small molecules such as phosphate anions, which are generally considered useless. The degradation of black phosphorus seriously affects its structure and performance, which limits the further application of the material, and is a key problem to be solved urgently. Black phosphorus can be degraded, and the degradation products are small molecules such as phosphate, ...

AI Technical Summary

Problems solved by technology

The degradation of black phosphorus seriously affects its structure and performance, which limits the further application of the material, and is a key problem to be solved urgently

Black phosphorus can be degraded, and the degradation products are small molecules such as phosphate, which is its advantage, but if it degrades too fast, it will easily lead to loss of function

Images