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Xuesaitong pharmaceutical composition as well as preparation method and application thereof

The technology of Xuesaitong and its composition is applied in the field of Xuesaitong pharmaceutical composition and its preparation, and achieves the effects of dispersing dosage forms, improving bioavailability and avoiding nausea

Pending Publication Date: 2021-02-05
XISHUANGBANNA HUAKUN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the problems existing in the prior art, the present invention provides a Xuesaitong pharmaceutical composition and its preparation method and application. Utilization issues

Method used

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  • Xuesaitong pharmaceutical composition as well as preparation method and application thereof
  • Xuesaitong pharmaceutical composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The Xuesaitong enteric-coated soft capsule containing Hevea seed oil of the present embodiment includes contents and soft capsule material, and the contents include the following components in parts by weight:

[0042] Panax notoginseng total saponins 30 parts,

[0043] 10 parts of silicon dioxide,

[0044] 7 parts polyacrylic resin,

[0045] 0.8 parts of triethyl citrate,

[0046] Rubber tree seed oil 45 parts,

[0047] 0.5 parts of beeswax,

[0048] Lecithin 0.5 part;

[0049] The soft capsule material comprises the following components in parts by weight:

[0050] 15 parts gelatin,

[0051] 2 parts of glycerin,

[0052] 5 parts of sorbitol,

[0053] 15 parts of purified water.

[0054] According to the above prescription amount, make the following preparations:

[0055] (1) Put the silicon dioxide in the granulation pot, start stirring at 100rpm, and close the cutter; add the total saponins of Panax notoginseng into the granulation pot with a peristaltic pump...

Embodiment 2

[0066] The Xuesaitong enteric-coated soft capsule containing Hevea seed oil of the present embodiment includes contents and soft capsule material, and the contents include the following components in parts by weight:

[0067] Panax notoginseng total saponins 35 parts,

[0068] Cyclodextrin 12 parts,

[0069] HPMCP 8 copies,

[0070] Triacetin 1.2 parts,

[0071] Rubber tree seed oil 50 parts,

[0072] Monoglyceride 1.0 parts,

[0073] Polysorbate 20 0.6 part;

[0074] The soft capsule material comprises the following components in parts by weight:

[0075] 18 parts gelatin,

[0076] 3 parts of glycerin,

[0077] 7 parts of sorbitol,

[0078] 18 parts of purified water.

[0079] According to the above prescription amount, make the following preparations:

[0080] (1) Put the cyclodextrin in the granulation pot, start stirring at 100rpm, and close the cutter; add the total saponins of Panax notoginseng into the granulation pot with a peristaltic pump, and stir for 12 m...

Embodiment 3

[0091] The Xuesaitong enteric-coated soft capsule containing Hevea seed oil of the present embodiment includes contents and soft capsule material, and the contents include the following components in parts by weight:

[0092] Panax notoginseng total saponins 20 parts,

[0093] 5 parts of silicon dioxide,

[0094] Polyacrylic resin 5 parts,

[0095] Rubber tree seed oil 40 parts,

[0096] The soft capsule material comprises the following components in parts by weight:

[0097] 15 parts gelatin,

[0098] 1 part of glycerin,

[0099] 5 parts of sorbitol,

[0100] Purified water 10 parts.

[0101] According to the above prescription amount, make the following preparations:

[0102] (1) Put the silicon dioxide in the granulation pot, start stirring at 80rpm, and close the cutter; add the total saponins of Panax notoginseng into the granulation pot with a peristaltic pump, and stir for 10 minutes after adding to obtain inclusion powder;

[0103] (2) Transfer the clathrate po...

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Abstract

The invention relates to a Xuesaitong pharmaceutical composition as well as a preparation method and application thereof. The pharmaceutical composition comprises the following components in parts byweight of 20-40 parts of total panax notoginseng saponins, 40-60 parts of rubber seed oil, 5-20 parts of an adsorbent, 5-10 parts of an enteric coating material, 0-1.5 parts of a plasticizer, 0-1.5 parts of a suspending aid and 0-1 part of an emulsifier. A preparation is jointly prepared from a Xuesaitong soft capsule and the rubber tree seed oil with the effect of reducing blood fat, and variousactive ingredients of the rubber tree seed oil and the effect of enhancing the immunity are combined, so that the defect of single performance of an original Xuesaitong medicine is improved; and the pharmaceutical composition has a good effect of preventing and treating cardio-cerebrovascular diseases caused by hyperlipidemia and blood stasis stagnation. The Xuesaitong pharmaceutical composition has the effects of Xuesaitong and is also used for stabilizing and reversing atherosclerotic plaques.

Description

technical field [0001] The invention belongs to the field of pharmaceutical composition processing, and in particular relates to a Xuesaitong pharmaceutical composition and its preparation method and application. Background technique [0002] Xuesaitong Tablets and Xuesaitong Soft Capsules are relatively mature cardiovascular and cerebrovascular drugs. Excavated before flowering, mainly distributed in Yunnan Province. The standard preparation method is as follows: take notoginseng and grind it into coarse powder, extract it with 70% ethanol, filter, concentrate the filtrate under reduced pressure, filter, and pass through a styrene-type non-polar or weakly polar copolymer macroporous adsorption resin column , washed with water, discarded the washing solution, eluted with 80% ethanol, concentrated the eluent under reduced pressure, decolorized, refined, concentrated under reduced pressure to extract, dried, and obtained. The main function of Panax notoginseng saponins is to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/48A61K47/44A61P3/06A61P9/00A61P9/10
CPCA61K9/4858A61K36/258A61P3/06A61P9/00A61P9/10
Inventor 王云吴玉成黄金成
Owner XISHUANGBANNA HUAKUN BIOTECH CO LTD