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Traditional Chinese medicine composition for treating migraine, nasal gel, preparation method and application

A technology of composition and gel, which is applied in the field of medicine, can solve problems such as gastrointestinal adverse reactions, abuse headaches, chronic migraines, and allergies, and achieve avoidance of liver first-pass effect, relief of headache symptoms, and bioavailability high effect

Inactive Publication Date: 2021-02-05
吉林大学中日联谊医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In summary, the current treatment for migraine can be divided into acute treatment and preventive treatment. Some acute treatment drugs such as non-steroidal anti-inflammatory drugs may have side effects such as gastrointestinal adverse reactions, allergies, and neutropenia; specificity The contraindications of analgesic drugs are complex; improper course of medication can also cause drug dependence or transform into drug abuse headache and chronic migraine
In addition, at present, there are various types of oral liquids, capsules and tablets prepared according to the "Da Chuanxiong Prescription" on the market, and these oral preparations are usually unable to quickly relieve headache symptoms due to their slow onset of action

Method used

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  • Traditional Chinese medicine composition for treating migraine, nasal gel, preparation method and application
  • Traditional Chinese medicine composition for treating migraine, nasal gel, preparation method and application
  • Traditional Chinese medicine composition for treating migraine, nasal gel, preparation method and application

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preparation example Construction

[0045] Preparation of Gastrodia elata extract: Take 120g Gastrodia elata, add 16 times the amount of 65% ethanol to reflux extraction, extract 4 times with alcohol, 1.5 hours each time, the extraction rate of gastrodin is 0.983%, combine the extracts, and select AB-8 macroporous resin , the concentration of the upper column solution is 0.5g / mL, the pH of the upper column solution is 8.0, the maximum sample volume is 0.7BV, the adsorption flow rate is 2-4BV / h, the ratio of diameter to height is 1:9, first elute with 1BV of distilled water, discard , and then eluted with 10% ethanol, the elution flow rate is 3-8BV / h, and the eluent volume is 6BV to purify the extract, and obtain about 1.0% Gastrodia elata extract.

[0046] Preparation of Rhizoma Chuanxiong Extract: Take 500g of Rhizoma Chuanxiong medicinal material, add 8 times the amount of 80% ethanol, ethanol extraction 3 times, 2 hours each time, combine the filtrate, recover ethanol under reduced pressure, concentrate until ...

Embodiment 1

[0049] This embodiment provides a kind of preparation method of the nasal gel for the treatment of migraine, which comprises the following steps:

[0050] S1. Weigh 10g of Chuanxiong extract, 0.5g of Gastrodia elata extract, 1g of Ziziphus jujube extract, 1g of menthol, 10g of gel matrix, 5g of humectant, 3g of solubilizer, 0.05g of antioxidant, and 0.01g of metal ion complexing agent , preservative 0.1g, spare. Among them, the gel matrix is ​​hydroxypropyl methylcellulose, the moisturizing agent is glycerin, the solubilizer is propylene glycol, the antioxidant is sodium bisulfite, the metal ion complexing agent is disodium edetate, and the preservative is trisodium Chlorobutanol.

[0051] S2. Mix the above weighed preservative with 10 g of distilled water to obtain mixture A.

[0052] S3. After mixing the weighed gel base and humectant, wetting and grinding, then adding the above-mentioned mixture A for mixing, stirring for a certain period of time to fully expand it, and o...

Embodiment 2

[0056] This embodiment provides a kind of preparation method of the nasal gel for the treatment of migraine, which comprises the following steps:

[0057] S1. Weigh 18g of Rhizoma Chuanxiong extract, 2g of Gastrodia elata extract, 5g of Jujube Seed extract, 3g of menthol, 20g of gel matrix, 15g of humectant, 7g of solubilizer, 0.5g of antioxidant, 0.05g of metal ion complexing agent, Preservative 1g, spare. Among them, the gel matrix is ​​hydroxypropyl methylcellulose, the moisturizing agent is glycerin, the solubilizer is propylene glycol, the antioxidant is sodium bisulfite, the metal ion complexing agent is disodium edetate, and the preservative is trisodium Chlorobutanol.

[0058] S2. Mix the above weighed preservative with 10 g of distilled water to obtain mixture A.

[0059] S3. After mixing the weighed gel base and humectant, wetting and grinding, then adding the above-mentioned mixture A for mixing, stirring for a certain period of time to fully expand it, and obtain...

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Abstract

The invention is applicable to the technical field of medicines, and provides a traditional Chinese medicine composition for treating migraine, nasal gel, a preparation method and application. The traditional Chinese medicine composition comprises the following components in parts by weight of 10-18 parts of ligusticum wallichii extract, 0.5-2 part of gastrodia elata extract, 1-5 parts of spina date seed extract and 1-3 parts of menthol. On the basis of a classic prescription of "Dachuanqiongfang" (a Chinese prescription mainly adopting ligusticum wallichii) for treating migraine, semen ziziphi spinosae plays a synergistic and complementary role, herba menthae is added to induce resuscitation and promote permeation, and the prescription conforms to related principles of traditional Chinesemedicine compatibility; the nasal gel prepared from the traditional Chinese medicine composition is relatively small in side effect and relatively high in safety, is superior to a traditional prescription in the aspects of rapid headache symptom relieving, lasting time relieving, stable and reliable curative effect and the like, can be used for medicine production practice, and is an ideal prescription expected to replace a traditional oral preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition for treating migraine, nasal gel, preparation method and application. Background technique [0002] Headache is a very common clinical symptom, which generally refers to pain in the upper part of the skull (brow arch, upper part of the auricle, and above the line of the external occipital inion). Among them, migraine is a recurrent headache disorder, mostly pulsating headache on one side, often accompanied by symptoms such as nausea and vomiting. According to statistics, the one-year prevalence rate of migraine is about 9.3%, and it is more common in women, and can occur at any age, among which the prevalence rate is higher in 40-49 years old. The disease has a high disability rate and a heavy burden, and the life and work of more than half of the patients are seriously affected. [0003] The etiology of migraine is still ...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/06A61K47/38A61P25/06A61K31/045
CPCA61K9/0043A61K9/06A61K31/045A61K36/236A61K36/725A61K36/8988A61K47/38A61P25/06A61K2300/00
Inventor 陈加俊李佳刘丽
Owner 吉林大学中日联谊医院
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