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C-SF-FA flexible conductive film based on silk fibroin, wearable wound monitoring sensor and preparation method thereof

A C-SF-FA and SF-FA technology, applied in the field of biomaterials, can solve the problems of poor air permeability, poor real-time data, poor biocompatibility, etc., and achieve good air permeability, lower production costs, and high sensitivity.

Pending Publication Date: 2021-02-05
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nowadays, some humidity sensors have been developed, but these sensors have many shortcomings, such as poor biocompatibility, poor air permeability and poor real-time data, etc.

Method used

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  • C-SF-FA flexible conductive film based on silk fibroin, wearable wound monitoring sensor and preparation method thereof
  • C-SF-FA flexible conductive film based on silk fibroin, wearable wound monitoring sensor and preparation method thereof
  • C-SF-FA flexible conductive film based on silk fibroin, wearable wound monitoring sensor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042]The preparation of a flexible and wearable wound monitoring sensor based on silk fibroin is performed according to the following steps:

[0043] 1) Bombyx silkworm cocoons are degummed with 2mol / L sodium carbonate solution. After degumming, wash and dry naturally. 2wv%, the formic acid concentration is 98wv%) is dissolved for more than 3 hours to form a silk fibroin solution (SF solution), and then the obtained SF solution is dried at room temperature for 24 hours to obtain silk fibroin. Then the obtained dried silk fibroin was soaked in deionized water for 10 hours to remove excess calcium chloride and formic acid, and dried. Then the obtained silk fibroin was dried at 35°C and dissolved in formic acid again to obtain a SF-FA electrospinning solution with a silk fibroin (SF) content of 20wv%.

[0044] 2) Dissolving 5 mg of dopamine (DA) in 1 ml of water, adding 5 mg of carbon nanotube (CNT) and ultrasonically dispersing to obtain a DA-CNT solution.

[0045] 3) The SF-...

Embodiment 2

[0049] The preparation of a flexible and wearable wound monitoring sensor based on silk fibroin is performed according to the following steps:

[0050] 1) Bombyx silkworm cocoons are degummed by boiling with 2mol / L sodium carbonate solution, washed and air-dried naturally after degumming is completed, and dissolved in lithium bromide / formic acid (FA) dissolution system after air-drying (wherein, the concentration of lithium bromide is 10wv%, the concentration of formic acid 98wv%) was dissolved for more than 3 hours to form a silk fibroin solution (SF solution), and then the obtained SF solution was dried at room temperature for 12 hours to obtain silk fibroin. Then the obtained dried silk fibroin was soaked in deionized water for 10 hours to remove excess lithium bromide and formic acid, and dried. Then the obtained silk fibroin was dried at 50° C. and dissolved in formic acid again to obtain a SF-FA electrospinning solution with a silk fibroin (SF) content of 20wv%.

[0051...

Embodiment 3

[0056] The preparation of a flexible and wearable wound monitoring sensor based on silk fibroin is performed according to the following steps:

[0057] 1) Bombyx silkworm cocoons are degummed with 2mol / L sodium carbonate solution. After degumming, wash and dry naturally. 5wv%, the formic acid concentration is 98wv%) is dissolved for more than 3 hours to form a silk fibroin solution (SF solution), and then the obtained SF solution is dried at room temperature for 24 hours to obtain silk fibroin. Then the obtained dried silk fibroin was soaked in deionized water for 10 hours to remove excess calcium chloride and formic acid, and dried. Then the obtained silk fibroin was dried at 45°C and dissolved in formic acid again to obtain a SF-FA electrospinning solution with a silk fibroin (SF) content of 20wv%.

[0058] 2) Dissolving 20 mg of dopamine (DA) in 1 ml of water, adding 10 mg of carbon nanotube (CNT) and ultrasonically dispersing to obtain a DA-CNT solution.

[0059] 3) The ...

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Abstract

The invention discloses a C-SF-FA flexible conductive film based on silk fibroin and a monitoring sensor made of the C-SF-FA flexible conductive film. The C-SF-FA flexible conductive film is preparedby the following steps of: 1) degumming silk, dissolving the silk in a salt-formic acid system to obtain a silk fibroin solution, performing drying to obtain silk fibroin, soaking the silk fibroin indeionized water, and dissolving the dried silk fibroin in formic acid again to obtain an SF-FA electrospinning solution; 2) dissolving dopamine in water, and adding carbon nanotubes to obtain a DA-CNTsolution; (3) preparing the SF-FA electrospinning solution into a flexible film through electrospinning, and spraying the DA-CNT solution onto the film for multiple times in the electrospinning process; airing the film to obtain a C-SF-FA conductive film; and 4) adding DA and CNT into an alkaline solution to obtain a PDA-CNT solution, soaking the C-SF-FA conductive film in the PDA-CNT solution, performing cleaning and drying, conducting soaking in an ethanol or methanol solution, and performing drying.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a silk fibroin-based C-SF-FA flexible conductive film, a wearable wound monitoring sensor and a preparation method thereof. Background technique [0002] The skin is the first barrier of human immunity and plays a pivotal role in protecting people's health. When the skin is damaged beyond repair, it will have a great impact on the body's interest-free system. Chronic wounds are a relatively common skin injury. For relatively minor burns, the skin will be repaired in an orderly manner. However, when the wound area is too large and too deep, the patient's own healing ability will not be enough to repair, which will be harmful to the patient. lives are threatened. Therefore, the treatment and monitoring of chronic wounds has received extensive attention from countries all over the world. [0003] Wound healing is a continuous and overlapping dynamic process that includes thr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/12
CPCG01N27/121G01N27/125
Inventor 熊兴良张铃钦赵祎铭江奇锋陈龙聪梁波袁杰
Owner CHONGQING MEDICAL UNIVERSITY
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